Metabolism coordinates the conversion of available nutrients toward energy, biosynthetic intermediates, and signaling molecules to mediate cellular functions. Dysregulation of metabolic pathways, i.e. genetic perturbation, i.e. via environmental stress and/or inflammatory signaling, contributes to many metabolic diseases, including cancer, inflammation, and brain disorders. However, our current knowledge of metabolic pathways and their regulation is still limited, so a detailed understanding of metabolism has significant therapeutic implications.
The overall theme of our research is to characterize metabolic heterogeneity and interconnectivity of cells and pathogens to better understand metabolism in driving cell function, focusing on metabolic flux, mass spectrometry, and engineering approaches. We expect that our research identifies metabolic vulnerabilities in inflammatory diseases, which can be influenced through targeted therapies.
Our current research centers on metabolic tracing approaches to understand how metabolism is reprogrammed in response to inflammatory signaling, nutrient availability, environmental stress, or genetic perturbation. Our specific research interests are:
to apply metabolic flux analysis and mass spectrometry approaches to identify metabolic vulnerabilities in cancer and inflammation
to characterize how genetic perturbations, microenvironment, intracellular signals, and small molecules impact metabolic fluxes and host-pathogen interactions
to understand inter- and intracellular transport mechanisms
to identify therapeutics and, ultimately, translate drug targets into the pharmaceutical industry
Thekla Cordes is a professor for Cellular Metabolism at the TU Braunschweig and HZI and applies mass spectrometry and tracing approaches to track metabolic pathways in mammalian cells. Taking this approach, her lab has made discoveries about how metabolism is reprogrammed in inflammation, cancer, and brain disorders. Cordes has an interdisciplinary and international training background that has spanned both industry and academic labs, covering metabolism, mass spectrometry, metabolic flux analysis strategies, and bioprocess engineering. At TU Braunschweig, her research will focus on identifying and exploiting metabolic vulnerabilities using mass spectrometry and tracing approaches to better understand metabolism in health and disease. Prior to joining TU Braunschweig, Cordes was a Project Scientist at the University of California, San Diego (UCSD) and SALK Institute for Biological Studies in La Jolla, US.
Hanna F. Willenbockel studiert Biologie und arbeitet an ihrer Masterarbeit in der Gruppe von Professorin Thekla Cordes. Diese Forschungsgruppe ist im Department für Bioinformatik und Biochemie am Braunschweiger Zentrum für Systembiologie (BRICS) angesiedelt. Dort untersucht sie, wie sich der Stoffwechsel von Immunzellen während einer Infektion verändert. Nebenbei engagiert sie sich für Wissenschaftskommunikation in den Biowissenschaften.
The offer at the Poster Marketplace of the research area “Infection and Therapeutics ” is huge. 40 projects and working groups with a total of 90 participants presented their research here on 19 July and at the same time gave a good overview of the wide range of the research focus. This ranges from research into neurodegenerative diseases to drug targeting and the creation of bioinformatic prognosis models. We took a look around the marketplace and spoke with some of the scientists.
Since mid-February 2022 Professor Thekla Cordes has been teaching and researching in the field of cellular metabolism at the TU Braunschweig at the BRICS. The biotechnologist studied in Braunschweig, but her work took her out into the world. Most recently she worked in the USA. As a scientist, she focuses on researching metabolism and how it influences human health.
Technische Universität Braunschweig Institute for Biochemistry, Biotechnology, and Bioinformatics Department of Bioinformatics and Biochemistry BRICS - Braunschweig Integrated Centre of Systems Biology Building 3210, rooms 130 - 133 Rebenring 56 38106 Braunschweig, Germany