Publikationen

seit 2020

  • Papenfuss, M., Lützow, S., Wilms, G., Babendreyer, A., Flaßhoff, M., Kunick, C., Becker, W.: Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B. Sci Rep. 2022, 12, 2393.
    DOI: 10.1038/s41598-022-06423-0
  • Lande, D. H., Nasereddin, A., Alder, A., Gilberger, T. W., Dzikowski, R., Grünefeld, J., Kunick, C.: Synthesis and antiplasmodial activity of bisindolylcyclobutenediones. Molecules 2021, 26, 4739.
    DOI: 10.3390/molecules26164739
  • Buchberger, A., Schepergerdes, L., Flaßhoff, M., Kunick, C., Köster, R.W.: A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression. J. Biol. Chem. 2021, 297, 100853.
    DOI: 10.1016/j.jbc.2021.100853
  • Ihnatenko, I., Jones, P. G., Kunick, C.: (E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one. Molbank 2021, 2012, M1293.
    DOI: 10.3390/M1293
  • Karatas, M., Chaikuad, A., Berger, B., Kubbutat, M. H.G., Totzke, F., Knapp, S., Kunick, C.: 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones designed by a “cut and glue” strategy are dual Aurora A/VEGF-R kinase inhibitors. Molecules 202126, 1611.
    DOI: 10.3390/molecules26061611
  • Müller, J. P., Scholl, S., Kunick, C., Klempnauer, K.-H.: Expression of protein kinase HIPK2 is subject to a quality control mechanism that acts during translation and requires its kinase activity to prevent degradation of nascent HIPK2. Biochim. Biophys. Acta, Mol. Cell Res. 20211868, 118894;
    DOI: 10.1016/j.bbamcr.2020.118894 
  • Schweda, S. I., Alder, A., Gilberger, T., Kunick, C.: 4-Arylthieno[2,3-b]pyridine-2-carboxamides are a new class of antiplasmodial agents. Molecules 2020, 25, 3187.
    DOI: 10.3390/molecules25143187
  • Medeiros, A., Benítez, D., Korn, R. S., Ferreira, V. C., Barrera, E., Carrión, F., Pritsch, O., Pantano, S., Kunick, C., de Oliveira, C. I., Orban, O. C. F., Comini, M. A.: Mechanistic and biological characterization of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania, J. Enzym. Inhib. Med. Chem. 2020, 35, 1345-1358.
    DOI: 10.1080/14756366.2020.1780227

2010-2019

  • Lechner, C., Flaßhoff, M., Falke, H., Preu, L., Loaëc, N., Meijer, L., Knapp, S., Chaikuad, A., Kunick, C.: [b]-Annulated halogen-substituted indoles as potential DYRK1A inhibitors. Molecules 2019, 24, 4090.
    DOI: 10.3390/molecules24224090
  • Masch, A., Nasereddin, A., Alder, A., Bird, M. J., Schweda, S. I., Preu, L., Doerig, C., Dzikowski, R., Gilberger, T. W., Kunick, C.: Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines. Malar J. 2019, 18, 89.
    DOI: 10.1186/s12936-019-2725-y

  • Rehbein, M. C., Wolters, J., Kunick, C., Scholl, S.: Continuous high-pressure operation of a pharmaceutically relevant Krapcho dealkoxycarbonylation reaction. J. Flow Chem. 2019, 9, 123-131.
    DOI: 10.1007/s41981-019-00031-2

  • Grünefeld, J., Kunick, C., Jones. P. G.: 1-(Imidazo[1,2-a]pyridin-1-ium-1-yl)-2,3,4-trioxocyclobutan-1-ide. Molbank 2019, 2019 (3), M1072.
    DOI: 10.3390/M1072

  • Mesías, A.C., Sasoni, N., Arias, D.G., Pérez Brandán, C., Orban, O.C.F., Kunick, C., Robello, C., Comini, M.A., Garg, N.J., Zago, M.P.: Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi. Free Rad. Biol. Med. 2019, 130, 23-34.
    DOI: 10.1016/j.freeradbiomed.2018.10.436
  • Shelar, S., Shim, E.-H., Brinkley, G.J., Kundu, A., Carobbio, F., Poston, T., Tan, J., Parekh, V., Benson, D., Crossman, D.K., Buckhaults, P.J., Rakheja, D., Kirkman, R., Sato, Y., Ogawa, S., Dutta, S., Velu, S.E., Emberley, E., Pan, A., Chen, J., Huang, T., Absher, D., Becker, A., Kunick, C., Sudarshan, S.: Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer. Clin. Cancer Res. 2018, 24, 6433-6446.
    DOI: 10.1158/1078-0432.CCR-18-1727
  • Lande, D.H., Kunick, C., Grünefeld, J.: 2,3,4-Trioxo-1-(1H-pyrrolo[2,3-b]pyridin-7-ium-7yl)-cyclobutan-1-ide. Molbank 2018, M1026
    DOI: 10.3390/M1026
  • Walter, A., Chaikuad, A., Helmer, R., Loaëc, N., Preu, L., Ott, I., Knapp, K., Meijer, L., Kunick, C.: Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
    PLoS ONE 2018, 13, e0196761.
    DOI: 10.1371/journal.pone.0196761
  • Meine, R., Becker, W., Falke, H., Preu, L., Loaëc, N., Meijer, L., Kunick, C.: Indole-3-carbonitriles as DYRK1A inhibitors by fragment-based drug design.
    Molecules 2018, 23, 64;
    DOI: 10.3390/molecules23020064
  • Meise, M., Niggemann, M., Dunens, A., Schoenitz, M., Kuschnerow, J. C., Kunick, C., Scholl, S.: Early process development of API applied to poorly water-soluble TBID.
    Eur. J. Pharm. Biopharm. 2018, 126, 2-9.
    DOI: 10.1016/j.ejpb.2018.01.008
  • Rehbein, M. C., Husmann, S., Lechner, C., Kunick, C., Scholl, S.: Fast and calibration free determination of first order reaction kinetics in API synthesis using in-situ ATR-FTIR.
    Eur. J. Pharm. Biopharm. 2018, 126, 95-100.
    DOI: 10.1016/j.ejpb.2017.09.013
  • Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G., Kunick, C.: Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors.
    Eur. J. Pharm. Biopharm.2018, 126, 89-94.
    DOI: 10.1016/j.ejpb.2017.03.011
  • Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., Kunick, C.:Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages.
    Malaria J. 2017, 16, 192 (1-10).
    DOI: 10.1186/s12936-017-1839-3
  • Meine, R., Blech, M., Lindhof, J., Kunick, C.: 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile.
    Molbank 2017, M941.
    DOI: 10.3390/M941
  • Walter, A., Chaikuad, A., Loaëc, N., Preu, L., Knapp, S., Meijer, L., Kunick, C., and Koch, O.: Identification of CLK1 inhibitors by a fragment-linking based virtual screening.
    Mol. Inf. 2017, 36, 1600123.
    DOI: 10.1002/minf.201600123
  • Grünefeld, J., Kunick, C., Jones, P.G.: (E)-2-(1-Cyano-2-methoxy-2-oxoethylidene)-3,4-dioxo-1-(pyridin-1-ium-1-yl)cyclobutan-1-ide.
    MolBank 2017, M953.
    DOI: 10.3390/M953
  • Orban, O. C. F., Korn, R. S., Benítez, D., Medeiros, A., Preu, L., Loaëc, N., Meijer, L., Koch, O., Comini, M. A., Kunick, C. : 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms. Bioorg. Med. Chem. 2016, 24, 3790-3800.
    DOI: 10.1016/j.bmc.2016.06.023
  • Prinz, B., Harvey, K. L., Wilcke, L., Ruch, U., Engelberg, K., Biller, L., Lucet, I., Erkelenz, S., Heincke, D., Spielmann, T., Doerig, C., Kunick, C., Crabb, B. S., Gilson, P. R., Gilberger, T. W.: Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites.
    Sci. Rep. 2016, 6, 34479.
    DOI: 10.1038/srep34479
  • Benítez, D., Medeiros, A., Fiestas, L., Panozzo-Zenere, E. A., Maiwald, F., Prousis, K. C., Roussaki, M., Calogeropoulou, T., Detsi, A., Jaeger, T., Šarlauskas, J., Mašič, L. P., Kunick, C., Labadie, G. R., Flohé, L., Comini: M. A., Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids. PLoS Negl. Trop. Dis. 2016, 10, e0004617.
    DOI: 10.1371/journal.pntd.0004617
  • Weidner, T., Nasereddin, A., Preu, L., Grünefeld, J., Dzikowski, R., Kunick, C.: Novel 2-phenoxyanilide congeners derived from a hit structure of the TCAMS: Synthesis and evaluation of their in vitro activity against
    Plasmodium falciparum. Molecules 2016, 21, 223.
    DOI: 10.3390/molecules21020223

  • Meise, M.,Schoenitz, M., Kunick, C., Scholl, S.: Entwicklung skalierbarer Verfahren für pharmazeutische Wirkstoffe am Beispiel TBID.
    Chemie Ingenieur Technik 2015, 87, 1098-1099.
    DOI: 10.1002/cite.201550116

  • Falke, H., Chaikuad, A., Becker, A., Loaëc, N., Lozach, O., Abu Jhaisha, S., Becker, W., Jones, P. G., Preu, L., Baumann, K., Knapp, S., Meijer, L., Kunick, C.: 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.
    J. Med. Chem. 2015, 58, 3131-3143.
    DOI: 10.1021/jm501994d
  • Masch, A., Kunick, C.: Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?
    Biochim. Biophys. Acta, Proteins Proteomics 2015, 1854, 1644-1649.
    DOI: 10.1016/j.bbapap.2015.03.013
  • Orban, O. C. F., Korn, R. S., Unger, L., Yildiz, A., Kunick, C.: 3-Chlorokenpaullone.
    Molbank 2015, M856.
    DOI: 10.3390/M856
  • Cozza, G., Zanin, S., Determann, R., Ruzzene, M., Kunick, C., Pinna, L. A.: Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).
    PLoS One 2014, 9, e89176.
    DOI: 10.1371/journal.pone.0089176
  • Maiwald, F., Benítez, D., Charquero, D., Dar, M. A., Erdmann, H., Preu, L., Koch, O., Hölscher, C., Loaëc, N., Meijer, L., Comini, M. A., Kunick, C.: 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.
    Eur. J. Med. Chem. 2014, 83, 274-283.
    DOI: 10.1016/j.ejmech.2014.06.020
  • Ryczak, J., Papini, M., Lader, A., Nasereddin, A., Kopelyanskiy, D., Preu, L., Jaffe, C. L., Kunick, C.: 2-Arylpaullones are selective antitrypanosomal agents.
    Eur. J. Med. Chem. 2013, 64, 396-400.
    DOI: 10.1016/j.ejmech.2013.03.065
  • Fugel, W., Oberholzer, A. E., Gschloessl, B., Dzikowski, R., Pressburger, N., Preu, L., Pearl, L. H., Baratte, B., Ratin, M., Okun, I., Doerig, C., Kruggel, S., Lemcke, T., Meijer, L., Kunick, C.: 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridin-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3.
    J. Med. Chem. 2013, 56, 264-275.
    DOI: 10.1021/jm301575n
  • Kupetz, E., Preu, L., Kunick, C., Bunjes, H.: Parenteral formulation of an antileishmanial drug candidate - tackling poor solubility, chemical instability and polymorphism.
    Eur. J. Pharm. Biopharm. 2013, 85, 511-520.
    DOI: 10.1016/j.ejpb.2013.02.001
  • Wölfel, S., Berndt, F., Friedrichs, J., Haese, M., Joostberends, J., Masri, B., Schnerre, R., Wabnik M., Kunick, C.: 4,5,6,7-Tetrachloro-2-(1H-imidazol-2-yl)isoindoline-1,3-dione.
    Molbank 2012, M785.
    DOI: 10.3390/M785
  • Determann, R., Dreher, J., Baumann, K., Preu, L., Jones, P. G., Totzke, F., Schächtele, C., Kubbutat, M. H. G., Kunick, C.: 2-Anilino-4-(benzimidazol-2-yl)pyrimidines - a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.
    Eur. J. Med. Chem. 2012, 53, 254-263.
    DOI: 10.1016/j.ejmech.2012.04.007
  • Huseby, S., Gausdal, G., Keen, T. J., Kjærland, E., Krakstad, C., Myhren, L., Brønstad, K., Kunick, C., Schwede, F., Genieser, G., Kleppe, R., Døskeland, S. O.: Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription.
    Cell Death Dis. 2011, 2, e237.
    DOI: 10.1038/cddis.2011.124
  • Tolle, N., Dunkel, U., Oehninger, L., Ott, I., Preu, L., Haase, T., Behrends, S., Jones, P. G., Totzke, F., Schächtele, C., Kubbutat, M. H. G., and Kunick, C.: Synthesis and structure of fluorescent chelate boron complexes of 4-anilinomethylidene-1-benzazepine-2,5-dione ligands.
    Synthesis 2011, 2848-2858.
    DOI: 10.1055/s-0030-1260165
  • Schmidt, S, Preu, L., Lemcke, T., Totzke, F., Schächtele, C., Kubbutat, M. H. G., and Kunick, C.: Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.
    Eur. J. Med. Chem. 2011, 46, 2759-2769.
    DOI: 10.1016/j.ejmech.2011.03.065
  • Lemcke, T., Dreher, J., Rarey, M., Totzke, F., Schächtele, C., Kubbutat, M. H. G., and Kunick, C.: Identification of inhibitors of the tyrosine kinase c-Met by structure-based virtual screening.
    Mol. Inf. 2011, 30, 145-150.
    DOI: 10.1002/minf.201000138
  • Egert-Schmidt, A.-M., Dreher, J., Dunkel, U., Kohfeld, S., Preu, L., Weber, H., Ehlert, J. E., Mutschler, B., Totzke, F., Schächtele, C., Kubbutat, M. H. G., Baumann, K., Kunick, C.: Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.
    J. Med. Chem. 2010, 53, 2433-2442.
    DOI: 10.1021/jm901388c
  • Brandt, W., Mologni, L., Preu, L., Lemcke, T., Gambacorti-Passerini, C., Kunick, C.: Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)-nicotinonitrile scaffold.
    Eur. J. Med. Chem. 2010, 45, 2919-2927.
    DOI: 10.1016/j.ejmech.2010.03.017
  • Kunick, C., Ott, I.: Metal complexes as protein kinase inhibitors.
    Angew. Chem. Int. Ed. Engl. 2010, 49, 5226-5227.
    DOI: 10.1002/anie.201002062
  • Becker, A., Kohfeld, S., Lader, A., Preu, L., Pies, T., Wieking, K., Ferandin, Y., Knockaert, M., Meijer, L., Kunick, C.: Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).
    Eur. J. Med. Chem. 2010, 45, 335-342.
    DOI: 10.1016/j.ejmech.2009.10.018

2000 - 2009

  • Lyssiotis, C. A., Foreman, R. K., Staerk, J., Garcia, M., Mathur, D., Meyerrose, T. E. Markoulaki, S., Hanna, J., Lairson, L. L., Charette, B. D., Bouchez, L., Bollong, M., Kunick, C., Brinker, A., Cho, C., Schultz, P. G., Jaenisch, R., Reprogramming of murine fibroblasts to iPS cells: Chemical complementation of Klf4.
    Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 8912-1917.
    DOI: 10.1073/pnas.0903860106
  • Becker, A., Kohfeld, S., Pies, T., Wieking, K., Preu, L., Kunick, C, Synthesis of 11H-indolo[3,2-c]quinoline-6-carboxylic acids by cascade autoxidation-ring contraction reactions.
    Synthesis 2009, 1185-1189.
    DOI: 10.1055/s-0028-1088014
  • Reichwald, C., Shimony, O., Dunkel, U., Sacerdoti-Sierra, N., Jaffe, C. L., and Kunick C., 2-(3-Aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: A new antileishmanial chemotype.
    J. Med. Chem. 2008, 51, 659-665.
    DOI: 10.1021/jm7012166
  • Reichwald, C., Shimony, O., Sacerdoti-Sierra, N., Jaffe, C. L., and Kunick C., A new Heck reaction modification using ketone Mannich bases as enone precursors: Parallel synthesis of anti-leishmanial chalcones.
    Bioorg. Med. Chem. Lett. 2008, 18, 1985-1989.
    DOI: 10.1016/j.bmcl.2008.01.112
  • Stukenbrock, H., Mußmann, R., Geese, M., Ferandin, Y., Lozach, O., Lemcke, T., Kegel, S., Lomow, A., Burk, U., Dohrmann, C., Meijer, L., Austen, M., and Kunick, C., 9-Cyano-1-azapaullone (cazpaullone), a GSK-3 inhibitor activating pancreatic beta cell protection and replication.
    J. Med. Chem. 2008, 51, 2196-2207.
    DOI: 10.1021/jm701582f
  • Kunick, C., Egert-Schmidt, A.-M., Jung, kompetitiv, erfolgreich: Die kurze Geschichte der Proteinkinase-Inhibitoren.
    Pharm. unserer Zeit 2008, 37, 360-368.
    DOI: 10.1002/pauz.200800277
  • Kohfeld, S., Jones, P. G., Totzke, F., Schächtele, C., Kubbutat, M. H. G., and Kunick, C.: 1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines.
    Eur. J. Med. Chem. 2007, 42, 1317-1324.
    DOI: 10.1016/j.ejmech.2007.02.007
  • Prühs, C. and Kunick, C.: Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis.
    Bioorg. Med. Chem. Lett. 2007, 17, 1850-1854.
    DOI: 10.1016/j.bmcl.2007.01.043
  • Trapp, J., Jochum, A., Meier, R., Saunders, L., Marshall, B., Kunick, C., Verdin, E., Goekjian, P., Sippl, W., Jung, M.: Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases - from kinase to sirtuin inhibition.
    J. Med. Chem. 2006, 49, 7307-7316.
    DOI: 10.1021/jm060118b
  • Kunick, C., Lemcke, T., Meijer, L.: Paullones. In: "Inhibitors of cyclin-dependent kinases as antitumor agents", P. J. Smith, E. Yue (Editors),
    CRC Press LLC, Boca Raton (USA), 2006, 227-249.
  • Kunick, C., Bleeker, C., Prühs, C., Totzke, F., Schächtele, C., Kubbutat, M. H. G., and Link, A.: Matrix COMPARE analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydro-benzo[b]cylopenta[e]azepine-4,10(1H,5H)-diones.
    Bioorg. Med. Chem. Lett. 2006, 16, 2148-2153.
    DOI: 10.1016/j.bmcl.2006.01.071
  • Xie, X., Lemcke, T., Gussio, R., Zaharevitz, D. W., Leost, M., Meijer, L., and Kunick C., Epoxide-containing side chains enhance antiproliferative activity of paullones.
    Eur. J. Med. Chem. 2005, 40, 655-661.
    DOI: 10.1016/j.ejmech.2005.02.004
  • McGrath, C.F., Pattabiraman, N., Kellogg, G. E., Lemcke, T., Kunick, C., Sausville, E. A., Zaharevitz, D. W., Gussio, R.: Homology Model of the CDK1/cyclin B Complex.
    J. Biomol. Struct. Dyn. 2005, 22, 493-502.
    DOI: 10.1080/07391102.2005.10531227
  • Meijer, L., Leost, M., Lozach, O., Schmitt, S., Kunick, C.: The paullones, a family of pharmacological inhibitors of cyclin-dependent kinases and glycogen synthase kinase -3. In "Handbook of Experimental Pharmacology" (HEP), L.A. Pinna & P.W. Cohen (Editors), "Inhibitors of Protein Kinases and Protein Phosphatases".
    Springer Verlag 2005, 48-64.
  • Kunick,C., Zeng, Z., Gussio, R., Zaharevitz, D., Leost, M., Totzke, F., Schächtele, C., Kubbutat, M. H. G., Meijer, L., Lemcke, T.: Structure-aided optimization of kinase inhibitors derived from alsterpaullone.
    ChemBioChem 2005, 6, 541-549.
    DOI: 10.1002/cbic.200400099
  • Kunick,C.: Novel molecular targets in cancer chemotherapy waiting for discovery.
    Curr. Med. Chem. Anti-Cancer Agents 2004, 4, 421-423.
    DOI: 10.2174/1568011043352858
  • Pies, T., Schaper, K.-J., Leost, M., Zaharevitz, D. W., Gussio, R., Meijer, L., Kunick, C.: CDK1-Inhibitory Activity of Paullones Depends on Electronic Properties of 9-Substituents.
    Arch. Pharm. Pharm. Med. Chem. 2004, 337, 486-492.
    DOI: 10.1002/ardp.200300870
  • Droucheau, E., Primot, A., Thomas, V., Mattei, D., Knockaert, M., Richardson, C., Sallicandro, P., Alano, P., Jafarshad, A., Baratte, B., Kunick, C., Parzy, D. Pearl, L., Doerig, C., Meijer, L.: Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors.
    Biochim. Biophys. Acta 2004, 1697, 181-196.
    DOI: 10.1016/j.bbapap.2003.11.023
  • Kunick, C., Lauenroth, K., Wieking, K., Xie, X., Schultz, C., Gussio, R., Zaharevitz, D., Leost, M., Meijer, L., Weber, A., Jørgensen, F., Lemcke, T.: Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5 and GSK-3 inhibition by paullones.
    J. Med. Chem. 2004, 47, 22-36.
    DOI: 10.1021/jm0308904
  • Kunick, C.; Lauenroth, K.; Leost, M.; Meijer, L.; Lemcke,T.: 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3.
    Bioorg. Med. Chem. Lett. 2004, 14, 413-416.
    DOI: 10.1016/j.bmcl.2003.10.062
  • Lahusen, T.; De Siervi, A.; Kunick, C.; Senderowicz, A. M.: Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.
    Mol. Carcinog. 2003, 36, 183-194.
    DOI: 10.1002/mc.10114
  • Knockaert, M., Wieking, K., Schmitt, S., Leost, M., Grant,K. M., Mottram, J. C., Kunick, C., Meijer, L: Intracellular targets of paullones: Identification following affinity purification on immobilized inhibitor.
    J. Biol.Chem. 2002, 277, 25493-25501.
    DOI: 10.1074/jbc.M202651200
  • Golisade, A.; Herforth, C.; Wieking, K.; Kunick, C.; Link,A.: Biotin labelling of amines by polymer assisted solution phase synthesis.
    Bioorg. Med. Chem. Lett. 2001, 11, 1783-1786.
    DOI: 10.1016/S0960-894X(01)00296-7
  • Leost, M., Schultz, C., Link, A., Wu, Y.-Z., Biernat, J., Mandelkow, E.-M., Bibb, J. A., Snyder, G. L., Greengard, P., Zaharevitz, D. W., Gussio, R., Senderowicz, A. M., Sausville, E. A., Kunick, C., Meijer, L: Paullones are potent inhibitors of glycogen synthase kinase-3b and cyclin-dependent kinase 5/p25.
    Eur. J. Biochem. 2000, 267, 5983-5994.
    DOI: 10.1046/j.1432-1327.2000.01673.x
  • Gussio, R., Zaharevitz, D. W., McGrath, C. F., Pattabiraman, N., Kellogg, G. E., Schultz, C., Link, A., Kunick, C., Leost, M., Meijer, L., Sausville, E. A.: Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition.
    Anti-Cancer Drug Des. 2000, 15, 53-66.
  • Kunick, C., Schultz, C., Lemcke, T., Zaharevitz, D. W., Gussio, R., Jalluri, R. K., Sausville, E. A., Leost, M., Meijer, L.: 2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.
    Bioorg. Med. Chem. Lett. 2000, 10, 567-569.
    DOI: 10.1016/S0960-894X(00)00048-2

1990 - 1999

  • Kunick, C.: Fused azepinones with antitumor activity.
    Curr. Pharm. Des. 1999, 5, 181-194.
  • Zaharevitz, D. W., Gussio, R., Leost, M., Senderowicz, A., Lahusen, T., Kunick, C., Meijer, L., Sausville, E. A.: Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.
    Cancer Res. 1999, 59, 2566-2569.
  • Schultz, C., Link, A., Leost, M., Zaharevitz, D. W., Gussio, R., Sausville, E. A.; Meijer, L.; Kunick, C.: Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/ cyclin B inhibition, and in vitro antitumor activity.
    J. Med. Chem. 1999, 42, 2909-2919.
    DOI: 10.1021/jm9900570
  • Sausville, E. A., Zaharevitz, D., Gussio, R., Meijer, L., Louarn-Leost,M.,Kunick, C., Schultz, R., Lahusen, T., Headlee, D., Stinson, S., Arbuck, S. G., Senderowicz, A.: Cyclin-dependent kinases: Initial approaches to exploit a novel therapeutic target.
    Pharmacol. Ther. 1999, 82, 285-292.
    DOI: 10.1016/S0163-7258(98)00062-X
  • Link, A., Zaharevitz, D. W., Kunick, C.: Antitumorpyrido[3,2- d][1]benzazepines: Synthesis and in vitro activity of thiophene analogs.
    Pharmazie 1999, 54, 163-166.
  • Bleeker, C., Kunick, C.: Naphthannelated azepinones: synthesis and antitumor activity.
    Pharmazie 1999, 54, 645-650
  • Link, A., Kunick, C.: d-Fused [1]benzazepines with selective in vitro antitumor activity: Synthesis and structure-activity relationships.
    J. Med. Chem. 1998, 41, 1299-1305.
    DOI: 10.1021/jm970675l
  • Link, A., Kunick, C.: Preparation of spiro[1-benzazepine-4,1'-cyclohexane] derivatives from 1H-1-benzazepine-2,5(3H, 4H)-diones and Mannich bases.
    Synthesis 1997, 297-300.
    DOI: 10.1055/s-1997-1176
  • Kunick, C., Link, A.; Hropot, M.: Synthesis and in vivo testing of a potential aquaretic agent.
    Pharmazie 1996, 51, 601-602.
  • Kunick, C.: Fused [1]benzazepines. Pentacyclic [1]benzazepines by reaction of 1H-[1]benzazepine-2,5(3H,4H)-dione with aldehydes.
    Heterocycles 1995, 41, 2299-2306.
    DOI: 10.3987/COM-95-7181
  • Kunick, C.: Synthese und konformative Flexibilität von 4,9-Dihydroindolo[3,2-d][1,2,4]triazolo[4,3-a]benzazepinen.
    Liebigs Ann. Chem. 1993, 1141-1143.
    DOI: 10.1002/jlac.1993199301182
  • Kunick, C.: Synthese von 7,12-Dihydro-indolo[3,2-d][1]benzazepin-6-(5H)-onen und 6,11-Dihydro-thieno-[3',2':2,3]azepino[4,5-b]indol-5(4H)-on.
    Arch. Pharm. (Weinheim) 1992, 325, 297-299.
    DOI: 10.1002/ardp.19923250509
  • Kunick, C.: Synthese [b]-kondensierter Azepindione durch Dealkoxycarbonylierung.
    Arch. Pharm. (Weinheim) 1991, 324, 579-581.
    DOI: 10.1002/ardp.2503240910

1985 - 1989

  • Kunick, C., Messinger, P.: Deuterierung enolisierbarer Ketone mit Deuterochloroform.
    Chem. Ber. 1986, 119, 1429-1431.
    DOI: 10.1002/cber.19861190428
  • Messinger, P., Kunick, C.: Eine bequeme Synthese von 2-Aroyl-5-aryl-pyrrolen.
    Synthesis 1986, 213-214.
    DOI: 10.1055/s-1986-31619
  • Messinger, P., Kunick, C.: 2-Sulfinyl-pentan-1,5-dione aus ß-Oxosulfoxiden.
    Arch. Pharm. (Weinheim) 1985, 318, 1045-1048.
    DOI: 10.1002/ardp.19853181116
  • Messinger, P., Kunick, C.: Additionsreaktionen von ß-Ketosulfoxiden und Bis(phenylsulfinyl)methan an Isocyanate.
    Arch. Pharm. (Weinheim) 1985, 318, 1086-1090.
    DOI: 10.1002/ardp.19853181206