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Vorländer, K., Kampen, I., Finke, J. H. & Kwade, A. Along the process chain to probiotic tablets: Evaluation of mechanical impacts on microbial viability. Pharmaceutics 12; 10.3390/pharmaceutics12010066 (2020).
Wagner, S., Sánchez, J., Leester-Schädel, M., Dietzel, A., Hutterer, J., Proll, G. & Gauglitz, G. 8th GMM-Workshop:. Micro-Nano-Integration, 74–79 (2020).
Wewers, M., Czyz, S., Finke, J. H., John, E., van Eerdenbrugh, B., Juhnke, M., Bunjes, H. & Kwade, A. Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process. Pharmaceutics 12; 10.3390/pharmaceutics12040363 (2020).
Wünsch, I., Friesen, I., Puckhaber, D., Schlegel, T. & Finke, J. H. Scaling tableting processes from compaction simulator to rotary presses—mind the sub-processes. Pharmaceutics 12; 10.3390/pharmaceutics12040310 (2020).
Abteilung 1: Pharmazeutisch-biologische Prozesse
Dittmann, J., Tesche, S., Krull, R. & Böl, M. The influence of salt-enhanced cultivation on the micromechanical behaviour of filamentous pellets. Biochemical Engineering Journal 148, 65–76; 10.1016/j.bej.2019.04.023 (2019).
Frey, L. J., Vorländer, D., Rasch, D., Ostsieker, H., Müller, B., Schulze, M., Schenkendorf, R., Mayr, T., Grosch, J.-H. & Krull, R. Novel electrodynamic oscillation technique enables enhanced mass transfer and mixing for cultivation in micro-bioreactor. Biotechnology Progress 35; 10.1002/btpr.2827 (2019).
Gaid, M., Füller, J. & Müller-Goymann, C. The Petroleum Ether Extract from Hypericum perforatum Root Cultures Exhibits Potent Antiproliferative Activity in Human Keratinocytes and Fibroblasts. Planta Medica 85, 591–598; 10.1055/a-0806-7735 (2019).
Gaid, M., Grosch, J.-H., Möller, S., Beerhues, L. & Krull, R. Toward enhanced hyperforin production in St. John's wort root cultures. Engineering in Life Sciences 19, 916–930; 10.1002/elsc.201900043 (2019).
Kleinfeldt, L., Gädke, J., Biedendieck, R., Krull, R. & Garnweitner, G. Spray-Dried Hierarchical Aggregates of Iron Oxide Nanoparticles and Their Functionalization for Downstream Processing in Biotechnology. ACS Omega 4, 16300–16308; 10.1021/acsomega.9b01549 (2019).
Lladó Maldonado, S., Panjan, P., Sun, S., Rasch, D., Sesay, A. M., Mayr, T. & Krull, R. A fully online sensor-equipped, disposable multiphase microbioreactor as a screening platform for biotechnological applications. Biotechnology and Bioengineering 116, 65–75; 10.1002/bit.26831 (2019).
Maldonado, S. L., Krull, J., Rasch, D., Panjan, P., Sesay, A. M., Marques, M., Szita, N. & Krull, R. Application of a multiphase microreactor chemostat for the determination of reaction kinetics of Staphylococcus carnosus. Bioprocess and Biosystems Engineering 42, 953–961; 10.1007/s00449-019-02095-9 (2019).
Mayr, J. C., Grosch, J.-H., Hartmann, L., Rosa, L., Spiess, A. C. & Harnisch, F. Resting Escherichia coli as Chassis for Microbial Electrosynthesis: Production of Chiral Alcohols. ChemSusChem 12, 1631–1634; 10.1002/cssc.201900413 (2019).
Nagia, M., Gaid, M., Biedermann, E., Fiesel, T., El-Awaad, I., Hänsch, R., Wittstock, U. & Beerhues, L. Sequential regiospecific gem-diprenylation of tetrahydroxyxanthone by prenyltransferases from Hypericum sp. New Phytologist 222, 318–334; 10.1111/nph.15611 (2019).
Pommerehne, K., Walisko, J., Ebersbach, A. & Krull, R. The antitumor antibiotic rebeccamycin—challenges and advanced approaches in production processes. Applied Microbiology and Biotechnology; 10.1007/s00253-019-09741-y (2019).
Tesche, S., Rösemeier-Scheumann, R., Lohr, J., Hanke, R., Büchs, J. & Krull, R. Salt-enhanced cultivation as a morphology engineering tool for filamentous actinomycetes: Increased production of labyrinthopeptin A1 in Actinomadura namibiensis. Engineering in Life Sciences 19, 781–794; 10.1002/elsc.201900036 (2019).
Abteilung 2: Pharmazeutisch-chemische Prozesse
Kahle, J., Zagst, H., Wiesner, R. & Wätzig, H. Comparative charge-based separation study with various capillary electrophoresis (CE) modes and cation exchange chromatography (CEX) for the analysis of monoclonal antibodies. Journal of Pharmaceutical and Biomedical Analysis 174, 460–470; 10.1016/j.jpba.2019.05.058 (2019).
Lechner, C., Flaßhoff, M., Falke, H., Preu, L., Loaëc, N., Meijer, L., Knapp, S., Chaikuad, A. & Kunick, C. [b]-annulated halogen-substituted indoles as potential DYRK1A inhibitors. Molecules 24; 10.3390/molecules24224090 (2019).
Masch, A., Nasereddin, A., Alder, A., Bird, M. J., Schweda, S. I., Preu, L., Doerig, C., Dzikowski, R., Gilberger, T. W. & Kunick, C. Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines. Malaria Journal 18; 10.1186/s12936-019-2725-y (2019).
Puschmann, J., Evers, D.-H., Müller-Goymann, C. C. & Herbig, M. E. Development of a design of experiments optimized method for quantification of polysorbate 80 based on oleic acid using UHPLC-MS. Journal of Chromatography A 1599, 136–143; 10.1016/j.chroma.2019.04.015 (2019).
Puschmann, J., Herbig, M. E. & Müller-Goymann, C. C. Influence of emulsifier concentration on partition behavior and chemical stability of betamethasone dipropionate in emulsion gels. International Journal of Pharmaceutics 562, 105–112; 10.1016/j.ijpharm.2019.02.044 (2019).
Rehbein, M. C., Wolters, J., Kunick, C. & Scholl, S. Continuous high-pressure operation of a pharmaceutically relevant Krapcho dealkoxycarbonylation reaction. Journal of Flow Chemistry 9, 123–131; 10.1007/s41981-019-00031-2 (2019).
Sauk, T., Henke, L., Xiao, C., Hartig, D. & Scholl, S. Continuous-Flow Di-N-Alkylation of 1H-Benzimidazole in a Fixed-Bed Reactor. Chemical Engineering and Technology 42, 2215–2222; 10.1002/ceat.201900114 (2019).
Abteilung 3: Formulierung und Verpackungstechnik
Ag Seleci, D., Maurer, V., Stahl, F., Scheper, T. & Garnweitner, G. Rapid Microfluidic Preparation of Niosomes for Targeted Drug Delivery. International Journal of Molecular Sciences 20; 10.3390/ijms20194696 (2019).
Brammann, C. & Mueller-Goymann, C. C. Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part I – Nanocrystalline benzoyl peroxide. International Journal of Pharmaceutics 564, 171–179; 10.1016/j.ijpharm.2019.04.031 (2019).
Brammann, C. & Müller-Goymann, C. C. Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part II – Solid-in-Oil dispersion of nanoparticulate benzoyl peroxide. International Journal of Pharmaceutics 572; 10.1016/j.ijpharm.2019.118792 (2019).
Cabiscol, R., Finke, J. H. & Kwade, A. Assessment of particle rearrangement and anisotropy in high-load tableting with a DEM-based elasto-plastic cohesive model. Granular Matter 21; 10.1007/s10035-019-0953-z (2019).
Gelker, M., Mrotzek, J., Ichter, A., Müller-Goymann, C. C. & Viöl, W. Influence of pulse characteristics and power density on stratum corneum permeabilization by dielectric barrier discharge. Biochimica et Biophysica Acta - General Subjects 1863, 1513–1523; 10.1016/j.bbagen.2019.05.014 (2019).
Groot, C. de, Müsken, M. & Müller-Goymann, C. C. The bidesmosidic triterpene saponins hederacoside C and ginsenoside Rb1 exhibit low affinity to cholesterol in liposomal membranes. Journal of Drug Delivery Science and Technology 53; 10.1016/j.jddst.2019.101127 (2019).
Melzig, S., Finke, J. H., Schilde, C., Vierheller, A., Dietzel, A. & Kwade, A. Fluid mechanics and process design of high-pressure antisolvent precipitation of fenofibrate nanoparticles using a customized microsystem. Chemical Engineering Journal 371, 554–564; 10.1016/j.cej.2019.04.051 (2019).
Melzig, S., Purr, F., Lorenz, T., Yan, Z., Finke, J. H., Schilde, C., Kwade, A. & Dietzel, A. Microfluidic spray drying device for process-oriented product development with low sample consumption. Microfluidics and Nanofluidics 23; 10.1007/s10404-019-2296-9 (2019).
Steiner, D., Finke, J. H. & Kwade, A. Model-based description of disintegration time and dissolution rate of nanoparticle-loaded orodispersible films. European Journal of Pharmaceutical Sciences 132, 18–26; 10.1016/j.ejps.2019.02.029 (2019).
Steiner, D., Finke, J. H. & Kwade, A. SOFTs – Structured orodispersible film templates. European Journal of Pharmaceutics and Biopharmaceutics 137, 209–217; 10.1016/j.ejpb.2019.03.001 (2019).
Tidau, M., Kwade, A. & Finke, J. H. Influence of high, disperse api load on properties along the fused-layer modeling process chain of solid dosage forms. Pharmaceutics 11; 10.3390/pharmaceutics11040194 (2019).
Wünsch, I., Finke, J. H., John, E., Juhnke, M. & Kwade, A. A mathematical approach to consider solid compressibility in the compression of pharmaceutical powders. Pharmaceutics 11; 10.3390/pharmaceutics11030121 (2019).
Abteilung 4: Mikroapparate und –analytik
Al-Halhouli, A., Albagdady, A., Al-Faqheri, W., Kottmeier, J., Meinen, S., Frey, L. J., Krull, R. & Dietzel, A. Enhanced inertial focusing of microparticles and cells by integrating trapezoidal microchambers in spiral microfluidic channels. RSC Advances 9, 19197–19204; 10.1039/c9ra03587g (2019).
Bolze, H., Erfle, P., Riewe, J., Bunjes, H., Dietzel, A. & Burg, T. P. A microfluidic split-flow technology for product characterization in continuous low-volume nanoparticle synthesis. Micromachines 10; 10.3390/mi10030179 (2019).
Constantinou, I., Jendrusch, M., Aspert, T., Görlitz, F., Schulze, A., Charvin, G. & Knop, M. Self-learning microfluidic platform for single-cell imaging and classification in flow. Micromachines 10; 10.3390/mi10050311 (2019).
Erfle, P., Riewe, J., Bunjes, H. & Dietzel, A. Stabilized production of lipid nanoparticles of tunable size in Taylor flow glass devices with high-surface-quality 3D microchannels. Micromachines 10; 10.3390/mi10040220 (2019).
Hinkel, S., Mattern, K., Dietzel, A., Reichl, S. & Müller-Goymann, C. C. Parametric investigation of static and dynamic cell culture conditions and their impact on hCMEC/D3 barrier properties. International Journal of Pharmaceutics 566, 434–444; 10.1016/j.ijpharm.2019.05.074 (2019).
Kottmeier, J., Wullenweber, M., Blahout, S., Hussong, J., Kampen, I., Kwade, A. & Dietzel, A. Accelerated particle separation in a DLD device at Re > 1 investigated by means of μPIV. Micromachines 10; 10.3390/mi10110768 (2019).
Meinen, S., Frey, L. J., Krull, R. & Dietzel, A. Resonant mixing in glass bowl microbioreactor investigated by microparticle image velocimetry. Micromachines 10; 10.3390/mi10050284 (2019).
Querschnittsgruppe 5: Multiskalen-Simulation pharmazeutischer Prozesse
Emenike, V. N., Xie, X., Krewer, U. & Schenkendorf, R. A point estimate method-based back-off approach to robust optimization: application to pharmaceutical processes. Computer Aided Chemical Engineering 46, 223-228; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069637459&doi=10.1016%2fB978-0-12-818634-3.50038-2&partnerID=40&md5=2f1b38fb5ff2b8d67cbdd1ca8b41fd19 (2019).
Emenike, V. N., Xie, X., Schenkendorf, R., Spiess, A. C. & Krewer, U. Robust dynamic optimization of enzyme-catalyzed carboligation: A point estimate-based back-off approach. Computers and Chemical Engineering 121, 232–247; 10.1016/j.compchemeng.2018.10.006 (2019).
Schenkendorf, R., Xie, X. & Krewer, U. An efficient polynomial chaos expansion strategy for active fault identification of chemical processes. Computers and Chemical Engineering 122, 228–237; 10.1016/j.compchemeng.2018.08.022 (2019).
Schrader, M., Pommerehne, K., Wolf, S., Finke, B., Schilde, C., Kampen, I., Lichtenegger, T., Krull, R. & Kwade, A. Design of a CFD-DEM-based method for mechanical stress calculation and its application to glass bead-enhanced cultivations of filamentous Lentzea aerocolonigenes. Biochemical Engineering Journal 148, 116–130; 10.1016/j.bej.2019.04.014 (2019).
Xie, X. & Schenkendorf, R. Robust optimization of a pharmaceutical freeze-drying process under non-Gaussian parameter uncertainties. Chemical Engineering Science 207, 805–819; 10.1016/j.ces.2019.06.023 (2019).
Xie, X. & Schenkendorf, R. Stochastic back-off-based robust process design for continuous crystallization of ibuprofen. Computers and Chemical Engineering 124, 80–92; 10.1016/j.compchemeng.2019.02.009 (2019).
Xie, X., Schenkendorf, R. & Krewer, U. Efficient sensitivity analysis and interpretation of parameter correlations in chemical engineering. Reliability Engineering and System Safety 187, 159–173; 10.1016/j.ress.2018.06.010 (2019).
Xie, X., Schenkendorf, R. & Krewer, U. The Effect of Correlated Kinetic Parameters on (Bio)Chemical Reaction Networks. Chemie-Ingenieur-Technik 91, 632–636; 10.1002/cite.201800201 (2019).
Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts – A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. 126, 108–114 (2018).
Mattern, K., Beißner, N., Reichl, S. & Dietzel, A. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 1 – Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. 126, 159–165 (2018).
Meise, M., Niggemann, M., Dunens, A., Schoenitz, M., Kuschnerow, J. C., Kunick, C. & Scholl, S. Early process development of API applied to poorly water-soluble TBID. Eur. J. Pharm. Biopharm. 126, 2–9 (2018).
Melzig, S., Niedbalka, D., Schilde, C. & Kwade, A. Spray drying of amorphous ibuprofen nanoparticles for the production of granules with enhanced drug release. Colloids Surfaces A Physicochem. Eng. Asp. 536, 133–141 (2018).
Haas, P., Gaid, M., Zarinwall, A., Beerhues, L. & Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. 126, 104–107 (2018).
Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. 126, 149–158 (2018).
Schenkendorf, R., Xie, X., Rehbein, M., Scholl, S. & Krewer, U. The impact of global sensitivities and design measures in model-based optimal experimental design. Processes 6, (2018).
Füller, J., Kellner, T., Gaid, M., Beerhues, L. & Müller-Goymann, C. C. Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro. Eur. J. Pharm. Biopharm. 126, 115–122 (2018).
Beinert, S., Fragnière, G., Schilde, C. & Kwade, A. Multiscale simulation of fine grinding and dispersing processes: Stressing probability, stressing energy and resultant breakage rate. Adv. Powder Technol. 29, 573–583 (2018).
Kahle, J., Maul, K. J. & Wätzig, H. The next generation of capillary electrophoresis instruments: Performance of CE-SDS protein analysis. Electrophoresis 39, 311–325 (2018).
Gädke, J., Thies, J.-W., Kleinfeldt, L., Schulze, T., Biedendieck, R., Rustenbeck, I., Garnweitner, G., Krull, R. & Dietzel, A. Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics. Eur. J. Pharm. Biopharm. 126, 67–74 (2018).
Beiβner, N., Mattern, K., Dietzel, A. & Reichl, S. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 2 – Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. 126, 166–176 (2018).
Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. 126, 89–94 (2018).
Lakowitz, A., Godard, T., Biedendieck, R. & Krull, R. Mini review: Recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives. Eur. J. Pharm. Biopharm. 126, 27–39 (2018).
Cabiscol, R., Finke, J. H. & Kwade, A. Calibration and interpretation of DEM parameters for simulations of cylindrical tablets with multi-sphere approach. Powder Technol. 327, 232–245 (2018).
Gaid, M., Biedermann, E., Füller, J., Haas, P., Behrends, S., Krull, R., Scholl, S., Wittstock, U., Müller-Goymann, C. & Beerhues, L. Biotechnological production of hyperforin for pharmaceutical formulation. Eur. J. Pharm. Biopharm. 126, 10–26 (2018).
Rehbein, M. C., Husmann, S., Lechner, C., Kunick, C. & Scholl, S. Fast and calibration free determination of first order reaction kinetics in API synthesis using in-situ ATR-FTIR. Eur. J. Pharm. Biopharm. 126, 95–100 (2018).
Meine, R., Becker, W., Falke, H., Preu, L., Loaëc, N., Meijer, L. & Kunick, C. Indole-3-carbonitriles as DYRK1A inhibitors by fragment-based drug design. Molecules 23, (2018).
Kahle, J. & Wätzig, H. Interlaced Size Exclusion Chromatography for faster protein analysis. Eur. J. Pharm. Biopharm. 126, 101–103 (2018).
Gelker, M., Müller-Goymann, C. C. & Viöl, W. Permeabilization of human stratum corneum and full-thickness skin samples by a direct dielectric barrier discharge. Clin. Plasma Med. 9, 34–40 (2018).
Beißner, N., Zorn-Kruppa, M. & Reichl, S. Parameter study of shipping conditions for the ready-to-use application of a 3D human hemicornea construct in drug absorption studies. Int. J. Pharm. 536, 377–387 (2018).
Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts – A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. 126, 108–114 (2018).
Mattern, K., Beißner, N., Reichl, S. & Dietzel, A. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 1 – Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. 126, 159–165 (2018).
Beiβner, N., Mattern, K., Dietzel, A. & Reichl, S. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 2 – Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. 126, 166–176 (2018).
Kahle, J. & Wätzig, H. Interlaced Size Exclusion Chromatography for faster protein analysis. Eur. J. Pharm. Biopharm. 126, 101–103 (2018).
Gädke, J., Thies, J.-W., Kleinfeldt, L., Schulze, T., Biedendieck, R., Rustenbeck, I., Garnweitner, G., Krull, R. & Dietzel, A. Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics. Eur. J. Pharm. Biopharm. 126, 67–74 (2018).
Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. 126, 149–158 (2018).
Lakowitz, A., Godard, T., Biedendieck, R. & Krull, R. Mini review: Recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives. Eur. J. Pharm. Biopharm. 126, 27–39 (2018).
Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. 126, 89–94 (2018).
de Groot, C., Müsken, M. & Müller-Goymann, C. Novel Colloidal Microstructures of β-Escin and the Liposomal Components Cholesterol and DPPC. Planta Med. 84, 1219–1227 (2018).
Lladó Maldonado, S., Rasch, D., Kasjanow, A., Bouwes, D., Krühne, U. & Krull, R. Multiphase microreactors with intensification of oxygen mass transfer rate and mixing performance for bioprocess development. Biochem. Eng. J. 139, 57–67 (2018).
Melzig, S., Finke, J. H., Schilde, C. & Kwade, A. Formation of long-term stable amorphous ibuprofen nanoparticles via antisolvent melt precipitation (AMP). Eur. J. Pharm. Biopharm. 131, 224–231 (2018).
Cabiscol, R., Finke, J., Zetzener, H. & Kwade, A. Characterization of Mechanical Property Distributions on Tablet Surfaces. Pharmaceutics 10, 184 (2018).
Xie, X., Schenkendorf, R. & Krewer, U. Toward a Comprehensive and Efficient Robust Optimization Framework for (Bio)chemical Processes. Processes 6, 183 (2018).
Puschmann, J., Herbig, M. E. & Müller-Goymann, C. C. Correlation of antimicrobial effects of phenoxyethanol with its free concentration in the water phase of o/w-emulsion gels. Eur. J. Pharm. Biopharm. 131, 152–161 (2018).
Emenike, V. N., Schenkendorf, R. & Krewer, U. Model-based optimization of biopharmaceutical manufacturing in Pichia pastoris based on dynamic flux balance analysis. Comput. Chem. Eng. 118, 1–13 (2018).
Abt, V., Barz, T., Cruz-Bournazou, M. N., Herwig, C., Kroll, P., Möller, J., Pörtner, R. & Schenkendorf, R. Model-based tools for optimal experiments in bioprocess engineering. Curr. Opin. Chem. Eng. 22, 244–252 (2018).
Peters, F., Gelker, M., Fleckenstein, M., Militz, H., Ohms, G. & Viöl, W. Decrease of the surface pH of maple and the production of nitrate by three pulsed dielectric barrier discharges. Wood Sci. Technol. 52, 1495–1510 (2018).
Mecklenfeld, A. & Raabe, G. Comparison of RESP and IPolQ-Mod Partial Charges for Solvation Free Energy Calculations of Various Solute/Solvent Pairs. J. Chem. Theory Comput. 13, 6266–6274 (2017).
Erfle, P., Riewe, J., Bunjes, H. & Dietzel, A. Optically monitored segmented flow for controlled ultra-fast mixing and nanoparticle precipitation. Microfluid. Nanofluidics 21, (2017).
Beißner, S., Thies, J.-W., Bechthold, C., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform. J. Sensors Sens. Syst. 6, 341–350 (2017).
Xie, X., Schenkendorf, R. & Krewer, U. Robust Design of Chemical Processes Based on a One-Shot Sparse Polynomial Chaos Expansion Concept. Comput. Aided Chem. Eng. 40, 613–618 (2017).
Schenkendorf, R., Xie, X. & Krewer, U. An Efficient Polynomial Chaos Expansion Strategy for Active Fault Identification of Chemical Processes. Comput. Aided Chem. Eng. 40, 1675–1680 (2017).
Göke, K., Lorenz, T., Repanas, A., Schneider, F., Steiner, D., Baumann, K., Bunjes, H., Dietzel, A., Finke, J. H., Glasmacher, B., Kwade, A. Novel strategies for the formulation and processing of poorly water-soluble drugs. Eur. J. Pharm. Biopharm. (2017).
Göke, K., Bunjes, H. Parameters influencing the course of passive drug loading into lipid nanoemulsions. Eur. J. Pharm. Biopharm. (2017).
Overbeck, A., Günther, S., Kampen, I. & Kwade, A. Compression Testing and Modeling of Spherical Cells – Comparison of Yeast and Algae. Chem. Eng. Technol. 40, (2017).
Thies, J.-W., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Microfluidic quartz-crystal-microbalance (QCM) sensors with specialized immunoassays for extended measurement range and improved reusability. Microelectron. Eng. 179, (2017).
Steiner, D., Finke, J. H., Kwade, A. Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness. Chemie-Ingenieur-Technik 89, (2017).
Schulze, T., Mattern, K., Früh, E., Hecht, L., Rustenbeck, I., Dietzel, A. A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets. Biomed. Microdevices 19, (2017).
Haas, P., Gaid, M., Zarinwall, A., Beerhues, L., Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. (2017).
Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., Kunick, C. Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages. Malaria J. (2017), 16, 192 (1-10).
Meine, R., Blech, M., Lindhof, J., Kunick, C., 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile. Molbank (2017), M941.
K. Mattern, N. Beissner, S. Reichl, A. Dietzel, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 1- Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. (2017).
N. Beissner, K. Mattern, A. Dietzel, S. Reichl, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 2- Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. (2017).
Gaid, M., Wucherpfennig, T., Scholl, S., Beerhues, L., Krull, R., Challenges for the cultivation of plant cells on the example of Hypericum perforatum and Taxus chinensis, in: A. Pavlov, T. Bley (Eds), Bioprocessing of plant in vitro systems, Reference Series in Phytochemistry, Springer, (2017) 1-26.
Füller J., Kellner T., Gaid M., Beerhues L., Müller-Goymann C.C. Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro. Eur. J. Pharm. Biopharm. (2017).
Göke, K., Lorenz, T., Repanas, A., Schneider, F., Steiner, D., Baumann, K., Bunjes, H., Dietzel, A., Finke, J. H., Glasmacher, B., Kwade, A. Novel strategies for the formulation and processing of poorly water-soluble drugs. Eur. J. Pharm. Biopharm. (2017).
Göke, K., Bunjes, H. Parameters influencing the course of passive drug loading into lipid nanoemulsions. Eur. J. Pharm. Biopharm. (2017).
Overbeck, A., Günther, S., Kampen, I. & Kwade, A. Compression Testing and Modeling of Spherical Cells – Comparison of Yeast and Algae. Chem. Eng. Technol. 40, (2017).
Thies, J.-W., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Microfluidic quartz-crystal-microbalance (QCM) sensors with specialized immunoassays for extended measurement range and improved reusability. Microelectron. Eng. 179, (2017).
Steiner, D., Finke, J. H., Kwade, A. Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness. Chemie-Ingenieur-Technik 89, (2017).
Schulze, T., Mattern, K., Früh, E., Hecht, L., Rustenbeck, I., Dietzel, A. A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets. Biomed. Microdevices 19, (2017).
Haas, P., Gaid, M., Zarinwall, A., Beerhues, L., Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. (2017).
Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., Kunick, C. Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages. Malaria J. (2017), 16, 192 (1-10).
Meine, R., Blech, M., Lindhof, J., Kunick, C., 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile. Molbank (2017), M941.
K. Mattern, N. Beissner, S. Reichl, A. Dietzel, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 1- Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. (2017).
N. Beissner, K. Mattern, A. Dietzel, S. Reichl, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 2- Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. (2017).
Gaid, M., Wucherpfennig, T., Scholl, S., Beerhues, L., Krull, R., Challenges for the cultivation of plant cells on the example of Hypericum perforatum and Taxus chinensis, in: A. Pavlov, T. Bley (Eds), Bioprocessing of plant in vitro systems, Reference Series in Phytochemistry, Springer, (2017) 1-26.
Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts - A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. (2017).
Gaid, M., Biedermann, E., Füller, J., Haas, P., Behrends, S., Krull, R., Scholl, S., Wittstock, U., Müller-Goymann, C. & Beerhues, L. Biotechnological production of hyperforin for pharmaceutical formulation. Eur. J. Pharm. Biopharm. (2017).
Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. (2017).
Gädke, J., Kleinfeldt, L., Schubert, C., Rohde, M., Biedendieck, R., Garnweitner, G. & Krull, R. In situ affinity purification of his-tagged protein A from Bacillus megaterium cultivation using recyclable superparamagnetic iron oxide nanoparticles. J. Biotechnol. 242, (2017).
Walisko, J., Vernen, F., Pommerehne, K., Richter, G., Terfehr, J., Kaden, D., Dähne, L., Holtmann, D. & Krull, R. Particle-based production of antibiotic rebeccamycin with Lechevalieria aerocolonigenes. Process Biochem. 53, (2017).
Lakowitz, A., Krull, R. & Biedendieck, R. Recombinant production of the antibody fragment D1.3 scFv with different Bacillus strains. Microb. Cell Fact. 16, (2017).
Mecklenfeld, A. & Raabe, G. Efficient solvation free energy simulations: impact of soft-core potential and a new adaptive λ-spacing method. Mol. Phys. (2017).
Göke K., Roese E., Arnold A., Kuntsche J., Bunjes H., Control over particle size distribution by autoclaving poloxamer-stabilized trimyristin nanodispersions, Mol. Pharmaceutics 13 (2016) 3187–3195.
Emenike, V. N. & Krewer, U. Model-Based Optimal Design of Continuous-Flow Reactors for the Synthesis of Active Pharmaceutical Ingredients. Chemie-Ingenieur-Technik 88, (2016).
Gehrmann S., Bunjes H., Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification, Chem. Eng. J. 284 (2016) 716–723.
Schenkendorf, R. Supporting the shift towards continuous pharmaceutical manufacturing by condition monitoring. in Conference on Control and Fault-Tolerant Systems, SysTol (2016).
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Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs - Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. (2016).
Orban, O. C. F., Korn, R. S., Benítez, D., Medeiros, A., Preu, L., Loaëc, N., Meijer, L., Koch, O., Comini, M. A. & Kunick, C. 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms. Bioorganic Med. Chem. 24, (2016).
Dietzel, A. Microsystems for pharmatechnology: Manipulation of fluids, particles, droplets, and cells. (2016).
Andermark, V., Göke, K., Kokoschka, M., Abu El Maaty, M. A., Lum, C. T., Zou, T., Sun, R. W.-Y., Aguiló, E., Oehninger, L., Rodríguez, L., Bunjes, H., Wölfl, S., Che, C.-M. & Ott, I. Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex. J. Inorg. Biochem. 160, (2016).
Weidner, T., Nasereddin, A., Preu, L., Grünefeld, J., Dzikowski, R., Kunick, C. Novel 2-phenoxyanilide congeners derived from a hit structure of the TCAMS: Synthesis and evaluation of their in vitro activity against plasmodium falciparum. Molecules 21, (2016).
Gaid, M., Haas, P., Beuerle, T., Scholl, S. & Beerhues, L. Hyperforin production in Hypericum perforatum root cultures. J. Biotechnol. 222, (2016).
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Schulze, T., Morsi, M., Brüning, D., Schumacher, K. & Rustenbeck, I. Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution. Endocrine 51, (2016).
El-Awaad, I., Bocola, M., Beuerle, T., Liu, B. & Beerhues, L. Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis. Nat. Commun. 7, (2016).
Eugen, K., Thies, J.-W. J.-W., Andreas, D., Koch, E., Thies, J.-W. J.-W. & Dietzel, A. Periodic convection of superparamagnetic beads within a microfluidic channel by interlocked, electroplated structures activated by a static field. Microelectron. Eng. 158, 46–51 (2016).
Dietzel, A. A brief introduction to microfluidics. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).
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Joseph S., Rappolt M., Schoenitz M., Huzhalska V., Augustin W., Scholl S., Bunjes H., Stability of the metastable α-polymorph in solid triglyceride drug carrier nanoparticles, Langmuir 31 (2015) 6663–6674.
Fiesel, T., Gaid, M., Müller, A., Bartels, J., El-Awaad, I., Beuerle, T., Ernst, L., Behrends, S. & Beerhues, L. Molecular cloning and characterization of a xanthone prenyltransferase from hypericum calycinum cell cultures. Molecules 20, (2015).
Meine, R., Falke, H., Kötz, J., Schweda, S. I. & Kunick, C. 7-iodo-1H-indole-3-carbonitrile. Molbank 2015, (2015).
Joseph S., Bunjes H., Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions, Eur. J. Pharm. Biopharm. 87 (2014) 176–186.
Wilkins, M. R., Aldashev, A. A., Wharton, J., Rhodes, C. J., Vandrovcova, J., Kasperaviciute, D., Bhosle, S. G., Mueller, M., Geschka, S., Rison, S., Kojonazarov, B., Morrell, N. W., Neidhardt, I., Surmeli, N. B., Aitman, T. J., Stasch, J.-P., Behrends, S. & Marletta, M. A. α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among kyrgyz highlanders. Circ. Cardiovasc. Genet. 7, (2014).
Wöhl-Bruhn S., Bertz A., Kuntsche J., Menzel H., Bunjes H., Variations in polyethylene glycol brands and their influence on the preparation process of hydrogel microspheres, Eur. J. Pharm. Biopharm. 85 (2013) 1215–1218.
Kupetz E., Preu L., Kunick C., Bunjes H., Parenteral formulation of an antileishmanial drug candidate – Tackling poor solubility, chemical instability, and polymorphism, Eur. J. Pharm. Biopharm. 85 (2013) 511–520.
Ryczak, J., Papini, M., Lader, A., Nasereddin, A., Kopelyanskiy, D., Preu, L., Jaffe, C. L. & Kunick, C. 2-Arylpaullones are selective antitrypanosomal agents. Eur. J. Med. Chem. 64, (2013).