TU BRAUNSCHWEIG

TU-rotes Quadrat GRK 2223/1: Protein Complex Assembly (PROCOMPAS)

Protein complex dynamics orchestrate biochemical processes at all stages of life. They are essential to control cellular metabolism, transport, regulation, structure and mobility. Therefore, they are strictly regulated and require factors that ascertain the temporal and spatial ordering of assemblies. Within the Research Program we will study central principles of protein complex assembly systematically using two representative model systems:


großes weißes A in dunkelgrünem QuadratThe eukaryotic molybdenum cofactor (Moco) biosynthesis
complex 
consisting of 11 proteins,

    and

großes weißes B in dunkelrotem Quadratthe electron transporting respirasome consisting of several dozen
proteins and a smaller  electron transfer model complex.

 

Both types of complexes are of essential importance for the organism and malfunction leads to death. The elucidation of these processes will advance our understanding of e.g. protein-protein interaction, ligand recognition, product-substrate channeling, posttranslational modifications, up to the formation of supramolecular complexes and their spatial positioning within the cell. In contrast to the importance of these mechanisms, our knowledge on the manifold facets of protein complex assembly is still limited.

TU-rotes Quadrat Contact

Prof. Dr. R.-R. Mendel
Speaker

TU Braunschweig
Institute for Plant Biology
Humboldtstr. 1
38106 Braunschweig
Germany

phone: +49 531 391 5870
fax: +49 0531 391 8128
e-mail: r.mendel@tu-braunschweig.de


Dr. Dagmar Zwerschke
Administrative Coordinator

TU Braunschweig
Institute for Plant Biology
Humboldtstr. 1
38106 Braunschweig
Germany

phone: +49 531 391 5878
e-mail: d.zwerschke@tu-braunschweig.de

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