Protein Complex Assembly (PROCOMPAS)

GRK 2223/1: Protein Complex Assembly (PROCOMPAS)

Protein complex dynamics orchestrate biochemical processes at all stages of life. They are essential to control cellular metabolism, transport, regulation, structure and mobility. Therefore, they are strictly regulated and require factors that ascertain the temporal and spatial ordering of assemblies. Within the Research Program we will study central principles of protein complex assembly systematically using two representative model systems:

(1) The eukaryotic molybdenum cofactor (Moco) biosynthesis complex consisting of 11 proteins,

(2) The electron transporting respirasome consisting of several dozen proteins and a smaller electron transfer model complex

Both types of complexes are of essential importance for the organism and malfunction leads to death. The elucidation of these processes will advance our understanding of e.g. protein-protein interaction, ligand recognition, product-substrate channeling, posttranslational modifications, up to the formation of supramolecular complexes and their spatial positioning within the cell. In contrast to the importance of these mechanisms, our knowledge on the manifold facets of protein complex assembly is still limited.


Prof. Dr. Klemens Rottner

TU Braunschweig
Zoological Institute
Molecular Cell Biology
Spielmannstraße 7/8
38106 Braunschweig

phone: +49531-391-5870
fax: +49 0531 391 8128
e-mail: k.rottner(at)


Dr. Dagmar Zwerschke
Administrative Coordinator

TU Braunschweig
Institute for Plant Biology
Humboldtstr. 1
38106 Braunschweig

phone: +49 531 391 5878
e-mail: d.zwerschke(at)