Escherichia coli chemotaxis is one of the most analyzed model systems of simple behavioural response. Chemotaxis allows bacteria to follow gradients of nutrients and environmental stimuli and further plays an important role in cooperative behaviour of bacteria and in virulence. The goal of this project is to investigate the origins and consequences of variation in expression of chemotaxis genes across the population, and to analyse the interplay between such population heterogeneity and cooperative behaviour in E. coli. chemotaxis.
References:
- List of publications (V. Sourjik)
Contact details:
Prof. Dr. Victor Sourjik
ZMBH
University of Heidelberg
Im Neuenheimer Feld 282
D-69120 Heidelberg
Germany
Tel.: +49-(0)6221-546858
Fax: +49-(0)6221-545892
v.sourjik(at)zmbh.uni-heidelberg.de
Homepage Link
Co-workers:
- Funded from SPP 1617: Verena Müller
References:
Sourjik
Bubendorfer, S., Koltai, M., Rossmann, F., Sourjik, V. and Thormann, K. M. (2014) Secondary bacterial flagellar system improves bacterial spreading by increasing the directional persistence of swimming. Proc. Natl. Acad. Sci. U.S.A., 111, 11485-11490.
Neumann, S., Grosse, K. and Sourjik, V. (2012) Chemotactic signaling via carbohydrate phosphotransferase systems in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A.
Schulmeister, S., Grosse, K. and Sourjik, V. (2011) Effects of receptor modification and temperature on dynamics of sensory complexes in Escherichia coli chemotaxis. BMC Microbiol., 11, 222.
Steuer, R., Waldherr, S., Sourjik, V. and Kollmann, M. (2011) Robust signal processing in living cells. PLoS Comput. Biol., 7, e1002218.
Oleksiuk, O., Jakovljevic, V., Vladimirov, N., Carvalho, R., Paster, E., Ryu, W. S., Meir, Y., Wingreen, N. S., Kollmann, M. and Sourjik, V. (2011) Thermal robustness of signaling in bacterial chemotaxis. Cell, 145, 312-321.
Vladimirov, N., Lebiedz, D. and Sourjik, V. (2010) Predicted auxiliary navigation mechanism of peritrichously flagellated chemotactic bacteria. PLoS Comput. Biol., 6, e1000717.
Kalinin, Y., Neumann, S., Sourjik, V. and Wu, M. (2010) Responses of Escherichia coli bacteria to two opposing chemoattractant gradients depend on the chemoreceptor ratio. J. Bacteriol., 192, 1796-1800.
Boehm, A., Kaiser, M., Li, H., Spangler, C., Kasper, C. A., Ackermann, M., Kaever, V., Sourjik, V., Roth, V. and Jenal, U. (2010) Second messenger-mediated adjustment of bacterial swimming velocity. Cell, 141, 107-116.
Kentner, D. and Sourjik, V. (2009) Dynamic map of protein interactions in the Escherichia coli chemotaxis pathway. Mol. Syst. Biol., 5, 238.
Løvdok, L., Bentele, K., Vladimirov, N., Müller, A., Pop, F. S., Lebiedz, D., Kollmann, M. and Sourjik, V. (2009) Role of translational coupling in robustness of bacterial chemotaxis pathway. PLoS Biol., 7, e1000171.