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  • AG Ebbinghaus - Biophotonik
Logo Institut für Physikalische und Theoretische Chemie der TU Braunschweig
  • AG Ebbinghaus - Biophotonik
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AG Ebbinghaus - Biophotonik

Research Aim

Most biopolymers like proteins, DNA, and RNA molecules function inside the cell, but are probed in vitro, under test tube conditions. We are interested in studying biomolecular structure, function and aggregation directly in cellular environments to yield new insight on their function in health and disease. Currently we focus on neurodegenerative diseases as well as bona/cartilage malformations and disordered hormone metabolisms based on impaired sulfation pathways.

Further information regarding our research can be found here

Our group

Featured Publications

Featured Publication 1:

TOC

Sequestration of Proteins in Stress Granules Relies on the In-Cell but Not the In Vitro Folding Stability

N. Samanta#, S S. Ribeiro#, M. Becker, E. Laborie, R. Pollak, S. Timr*, F. Sterpone*, S. Ebbinghaus*

J. Am. Chem. Soc., 2021.

Please log in to get access to the paper

 

Featured Publication 2:

Abbildung der Punktmutationen in SOD1

Stability Effect of Quinary Interactions Reversed by Single Point Mutations

D. Gnutt, S. Timr, J. Ahlers, B. König, E. Manderfeld, M. Heyden, F. Sterpone, S. Ebbinghaus

J. Am. Chem. Soc., 2019, 141, 11, 4660

Please log in to get access to the paper

 

Featured Publication 3:

Huntingtin Exon 1 und CLR01

Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01

T. Vöpel, K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klärner, T. Schrader, G. Bitan, E. E. Wanker,  S. Ebbinghaus*, E. Sanchez-Garcia*

J. Am. Chem. Soc., 2017, 139, 16, 5640.

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Featured Publication 4:

RNA Temperatur Experiment

RNA Hairpin Folding in the Crowded Cell

M. Gao, D. Gnutt, A. Orban, B. Appel, F. Righetti, R. Winter, F. Narberhaus, S. Müller, S. Ebbinghaus

Angew. Chem. Int. Ed., 2016, 55, 9, 3224.

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News

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How proteins clump together

Molecular mechanisms involved in protein aggregation in membrane-less organelles

What happens when our cells are exposed to prolonged stress? Untypical cell behavior is the result and diseases develop.

Click here for the full article

 

TOC
Zellen mit Bodypyies

How to illuminate a cell nucleus

TU Braunschweig develops sugar-based dye molecules

The research groups of Prof. Dr. D. B. Werz and Prof. Dr. S. Ebbinghaus have found a way to label cells with sugar-based dyes and observe them using fluorescence.

Click here for the full article

Against Alzheimer's & Co: Misfolding of proteins studied

"In-Cell" experiments to be continued in DFG priority program

How protein misfoldings in cells can trigger diseases such as Huntington's disease, Alzheimer's and Parkinson's. A study of protein stability through mutations.

Click here for the full article

 

Current Funding

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Research Groups

Bauerecker Group
Ebbinghaus Group
Hohm Group 
Jacob Group
Maul Group
Proppe Group
Tschierlei Group 
Walla Group

Associated Groups
Muñoz Group (GRS)

Emeriti
Becker Group
Gericke Group

Former Groups
Acuna Group
Elstner Group
Grohmann Group
Neugebauer Group
Tinnefeld Group

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Contact

Technische Universität Braunschweig
Institute of Physical und Theoretical Chemistry

Gaußstraße 17
38106 Braunschweig
P. O. Box 3329, 38023 Braunschweig
Germany
Phone +49 (531) 391-7383

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