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  • AG Ebbinghaus - Biophotonik
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Logo Institut für Physikalische und Theoretische Chemie der TU Braunschweig

Publications

2021

GlycoBODIPYs: Sugars Serving as Natural Stock for Water-soluble Flourescent Probes of Complex Chiral Morphology

L. J. Patalag*#, S. Ahadi#, O. Lashchuk, P. G. Jones, S. Ebbinghaus, D. B. Werz*

Angew. Chem. Int. Ed., 2021 (accepted).

Targeted to ER and lysosome Chemical Charperones Prevented Neurodegeneration in C9orf72 Repeat Expansion Drosophila ALS Model

S. Azoulay-Ginsburg#, M. Di Salvio, S. Ribeiro, M. Weitman, M. Afri, S. Ebbinghaus, G. Cestra, A. Gruzman*

Pharmacol. Rep., 2021 (accepted).

Micro-XRF analysis of trace element distribution in frozen hydrated HeLa cells at the P06 beamline at Petra III

C. Rumancev, T. Vöpel, S. Stuhr, A. R. von Gundlach, T. Senkbeil, S. Ebbinghaus, J. Garrevoet, G. Falkenberg, B. De Samber, L. Vincze, A. Rosenhahn*, W. Schröder*

Biointerphases, 2021 (accepted).

Thermodynamic Analysis of the Self-Assembly of Pseudo Isocyanine Chloride in the Presence of Crowding Agents

B. Hämisch#, R. Pollak#, S. Ebbinghaus*, K. Huber*

ChemSystemsChem, 2021 (accepted).

Folding stability and self‐association of a triplet‐repeat (CAG)_20 RNA hairpin in cytomimetic media

A. C. Hautke, S. Ebbinghaus*

ChemSystemsChem, 2021 (accepted).

In cellulo analysis of Huntingtin inclusion bodies by cryogenic nanoprobe SAXS

C. Rumancev*, T. Vöpel, S. Stuhr, A. von Gundlach, T. Senkbeil, M. Osterhoff, M. Sprung, V. Garamus, S. Ebbinghaus*, A. Rosenhahn*

ChemSystemsChem, 2021 (accepted).


2020

The Unfolding Journey of Superoxide Dismutase 1 Barrels Under Crowding: Atomistic Simulations Shed Light on Intermediate States and Their Interactions With Crowders

S. Timr, D. Gnutt, S. Ebbinghaus, F. Sterpone

The Journal of Physical Chemistry Letters, 2020

Self‐Assembly of Pseudo‐Isocyanine Chloride as a Sensor for Macromolecular Crowding in vitro and in vivo

B. Hämisch#, R. Pollak#, S. Ebbinghaus*, K. Huber*

Chemistry - A European Journal, 2020

X-ray fluorescence analysis of metal distributions in cryogenic biological samples using large-acceptance-angle SDD detection and continuous scanning at the Hard X-ray Micro/Nano-Probe beamline P06 at PETRA III

C. Rumancev, A. Gräfenstein, T. Vöpel, S. Stuhr, A. R. von Gundlach, T. Senkbeil, J. Garrevoet, L. Jolmes, B. König, G. Falkenberg, S. Ebbinghaus, W. H. Schroeder, A. Rosenhahn

Journal of Synchrotron Radiation, 2020

Thermal Stability Modulation of Native and Chemically-Unfolded State of Bovine Serum Albumin by Amino Acids

S. Pal, P. Pyne, N. Samanta, S. Ebbinghaus*, R. K. Mitra*

Physical Chemistry Chemical Physics, 2020


2019

The synergic effect of water and biomolecules in intracellular phase separation

S. S. Ribeiro, N. Samanta, S. Ebbinghaus, J. C. Marcos*

Nature Reviews Chemistry, 2019.

Effects of in vivo conditions on amyloid aggregation

M.C. Owen#, D. Gnutt#, M. Gao#, S. Warmländer, J. Jarvet, A. Gräslund, R. Winter, S. Ebbinghaus, B. Strodel*

Chem. Soc. Rev., 2019.

Protein Folding Modulation in Cells Subject to Differentiation and Stress

D. Gnutt, L. Sistemich, S. Ebbinghaus*

Front. Mol. Biosci., 2019.

Melting Down Protein Stability: PAPS Synthase 2 in Patients and in a Cellular Environment

O. Brylski, S. Ebbinghaus*, J.W. Mueller*

Front. Mol. Biosci., 2019.

Stability Effect of Quinary Interactions Reversed by Single Point Mutations

D. Gnutt, S. Timr, J. Ahlers, B. König, E. Manderfeld, M. Heyden, F. Sterpone, S. Ebbinghaus*

J.Am.Chem.Soc., 141(11), 4660-4669, 2019.


2018

Protein folding and quinary interactions: Creating cellular organization through functional disorder

S.S. Ribeiro, S. Ebbinghaus, J.C. Marcos*

FEBS Letters, 592.18, 3040-3053 2018.

Macromolecular crowding effects in flexible polymer solutions

B.B. Majumdar, S. Ebbinghaus, M.Heyden*

Journal of Theoretical and Computational Chemistry, 17, 1840006, 2018.

A biosensor-based framework to measure latent proteostasis capacity

R.J. Wood, A.R. Ormsby, M. Radwan, D. Cox, A. Sharma, T. Vöpel, S. Ebbinghaus, M. Oliveberg, G.E. Reid, A. Dickson, D.M. Hatters*

Nature Communications, 287, 2018.

A multi-perspective approach to solvent regulation of enzymatic activity: HMG-CoA reductase

M. Dirkmann, J. Iglesias, V. Muñoz, P. Sokkar, C. Rumancev, A. von Gundlach, O. Krenczyk, T. Vöpel, J. Nowack, M.A. Schroer, S. Ebbinghaus, C. Herrmann, A. Rosenhahn, E. Sanchez-Garcia* and F. Schulz*

ChemBioChem, 19(2), 153-158, 2018.


2017

Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes

D. Gnutt, O. Brylski, E. Edengeiser, M. Havenith, S. Ebbinghaus*

Molecular BioSystems, 13, 2218-21, 2017.

Elucidation of the Catalytic Mechanism of a Miniature Zinc Finger Hydrolase

A. Ganguly, T. Luong, O. Brylski, M. Dirkmann, D. Möller, S. Ebbinghaus, F. Schulz, R. Winter, E. Sanchez-Garcia*, W. Thiel*

Journal of Physical Chemistry B, 21(26):6390–6398, 2017.

Inhibition of Huntingtin Exon‑1 Aggregation by the Molecular Tweezer CLR01

T. Vöpel, K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klärner, T. Schrader, G. Bitan, E. E. Wanker, S. Ebbinghaus*, E. Sanchez-Garcia*

J. Am. Chem. Soc., 139(16):5640–5643, 2017.

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

S. Büning, A. Sharma, S. Vachharajani, E. Newcombe, A. Ormsby, M. Gao, D. Gnutt, T. Vöpel, D. M. Hatters, S. Ebbinghaus*

Phys. Chem. Chem. Phys., 19, 10738-10747, 2017.

Das Innere der Zelle: Ein komplexes Lösungsmittel

M. Heyden, S. Ebbinghaus, R. Winter

Chemie in unserer Zeit, 51(1), 26–33, 2017.


2016

The Temperature Dependence of the Hofmeister Series: Thermodynamic Fingerprints of Cosolute-Protein Interactions

M. Senske, D. Constantinescu, M. Havenith, C. Herrmann*, H. Weingärtner, S. Ebbinghaus*

Phys. Chem. Chem. Phys., 18, 29698-29708, 2016.

RNA hairpin folding in the crowded cell

M. Gao#, D. Gnutt#, A. Orban, B. Appel, F. Righetti, R. Winter, F. Narberhaus, S. Müller, S. Ebbinghaus*

Angew. Chem. Int. Ed., 55(9):3224-8, 2016.

Simultaneous measurements of photocurrents and H2O2 evolution from solvent exposed Photosystem 2 complexes

T. Vöpel, E.N. Saw, V. Hartmann, R. Williams, F. Müller, W. Schuhmann, N. Plumeré, M. Nowaczyk, S. Ebbinghaus*, M. Rögner*

Biointerphases, 11, 019001, 2016.

Vom Reagenzglas in die Zelle

D. Gnutt, M. Heyden* and S. Ebbinghaus*

Nachrichten aus der Chemie (Trendbericht Physikalische Chemie), 03/2016.

The macromolecular crowding effect – from in vitro into the cell

D. Gnutt and S. Ebbinghaus*

Biol. Chem., 397(1):37-44, 2016.

Protein stability in crowded environments

M. Senske, S. Ebbinghaus and C. Herrmann*

Book chapter in Biocalorimetry: Foundations and Contemporary Approaches (Taylor & Francis), 13:241-253, 2016.


2015-2011

Infrared laser triggered release of bioactive compounds from single hard shell microcapsules

T. Vöpel, R. Scholz, L. Davico, M. Groß, S. Büning, S. Kareth, E. Weidner and S. Ebbinghaus*

Chem. Commun., 51, 6913-6916, 2015.

Excluded volume effects in the living cell

D. Gnutt, M. Gao, O. Brylski, M. Heyden and S.Ebbinghaus*

Angew. Chem. Int. Ed., 54(8):2548-51, 2015.

Modulation of human IAPP fibrillation: Cosolutes, crowders and chaperones

M. Gao, K. Estel, J. Seeliger, R.P. Friedrich, S. Dogan, E.E. Wanker, R. Winter and S. Ebbinghaus*

Phys. Chem. Chem. Phys., 17, 8338-48, 2015. 

Non-invasive chemical assessment of living human spermatozoa

E. Edengeiser, K. Meister, E. Bründermann, S. Büning, S. Ebbinghaus, M. Havenith*

RSC Advances, (5), 10424-10429, 2015.

Understanding the ‘native’ solvent – from the test tube into the cell

M. Senske, S. Büning and S. Ebbinghaus*

Bunsenmagazin, (6), 276–281, 2014.

Protein Stabilization by Macromolecular Crowding through Enthalpy rather than Entropy

M. Senske, L. Törk, B. Born, M. Havenith, C. Herrmann and S. Ebbinghaus*

J. Am. Chem. Soc., 136 (25), 9036–9041, 2014.

Relaxationskinetik in lebenden Zellen

S. Büning, S. Ebbinghaus*

BIOspektrum, 20(4), 383-385, 2014.

Particle Dynamics Microscopy Using Temperature Jump and Probe Anticorrelation/Correlation Techniques

M. Gruebele, S. Ebbinghaus, A. Dhar, J. D. McDonald

US patent 8,757,871, 2014.

Probing solvation dynamics by THz absorption spectroscopy

B. Born, M. Heyden, S. Ebbinghaus and M. Havenith*

Terahertz Biomedical Science and Technology, CRC Press, 2014.

Long-range protein-water dynamics in hyperactive insect antifreeze proteins

K. Meister, S. Ebbinghaus, Y. Xu, J.G. Duman, A.L. DeVries, M. Gruebele, D.M. Leitner and M. Havenith*

Proc. Nat. Acad. Sci. USA, 110(5):1617-1622, 2013.

"How An Insect Version Of Antifreeze Works" Veröffentlichung in Chemical & Engineering News

Functional Importance of Short-Range Binding and Long-Range Solvent Interactions in Helical Antifreeze Peptides

S. Ebbinghaus, K. Meister, M. B. Prigozhin, A. L. DeVries, M. Havenith, J. Dzubiella, and M. Gruebele*

Biophys. J., 103:20-22, 2012.

Protein Stability and Folding Kinetics in the Nucleus and Endoplasmic Reticulum of Eucaryotic Cells

A. Dhar, K. Girdhar, D. Singh, H. Gelman, S. Ebbinghaus, M. Gruebele*

Biophys. J., 101:1-10, 2011.

Protein Folding Landscapes in the Living Cell

S. Ebbinghaus and M. Gruebele*

J. Phys. Chem. Lett., 2:314-319, 2011.


2010-2003

Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding

A. Dhar, A. Samiotakis, S. Ebbinghaus, L. Nienhaus, D. Homouz, M. Gruebele, M.S. Cheung*

Proc. Nat. Acad. Sci. USA, 107:17586-17591, 2010.

The diffusion coefficient for PGK folding in eukaryotic cells

A. Dhar#, S. Ebbinghaus#, Z. Shen, T. Mishra, M. Gruebele*

Biophys. J., 99:69-71, 2010.

Antifreeze glycoprotein activity correlates with long-range protein-water dynamics

S. Ebbinghaus, K. Meister, B. Born, A. L. DeVries, M. Gruebele and M. Havenith*

J. Am. Chem. Soc., 132:12210-12211, 2010.

Terahertz Spectroscopy as a Tool to Study Hydration Dynamics

M. Heyden, S. Ebbinghaus, M. Havenith*

Encyclopedia of Analytical Chemistry, Analytical Chemistry, eds R.A. Meyers, John Wiley: Chichester, 2010.

Protein folding stability and dynamics imaged in a living cell

S. Ebbinghaus, A. Dhar, J.D. McDonald and M. Gruebele*

Nature Methods, 7:319-323, 2010.

The terahertz dance of water with the proteins: the effect of protein flexibility on the dynamical hydration shell of ubiquitin

B. Born, S.J. Kim, S. Ebbinghaus, M. Gruebele, M. Havenith*

Faraday Discuss., 141:161-173, 2009.

Protein sequence- and pH-dependent hydration probed by Terahertz spectroscopy

S. Ebbinghaus, S.J. Kim, M. Heyden, X. Yu, M. Gruebele, D. Leitner and M. Havenith*

J. Am. Chem. Soc., 130:2374-2375, 2008.

An extended dynamical solvation shell around proteins

S. Ebbinghaus, S.J. Kim, M. Heyden, X. Yu, U. Heugen, M. Gruebele, D. Leitner and M. Havenith*

Proc. Nat. Acad. Sci. USA, 104:20749-20752, 2007.

Terahertz time-domain spectroscopy as a new tool for the characterization of dust forming plasmas

S. Ebbinghaus, K. Schröck, J.C. Schauer, E. Bründermann, M. Heyden, G. Schwaab, M. Böke, J. Winter, M. Tani and M. Havenith*

Plasma Sources Sci.Technol., 15:72-77, 2006.

Terahertz Imaging Applications in Spectroscopy of Biomolecules

E. Bründermann, U. Heugen, R. Schiwon, B. Born, G.W. Schwaab, S. Ebbinghaus, K. Schröck, D.R. Chamberlin, E.E. Haller and M. Havenith*

Microwave Symposium Digest, IEEE MTT-SInternational:625-628, 2005.

High resolution spectroscopy of the ν3 band of DCOOD

F. Madeja, A. Hecker, S. Ebbinghaus and M. Havenith*

Spectrochimica Acta Part A, 59:1773, 2003.

High resolution spectroscopy of the ν3 band of the van der Waals complex Ar-DCOOH

F. Madeja, A. Hecker, S. Ebbinghaus and M. Havenith*

Mol. Phys., 101:1511, 2003.

Research Groups

Bauerecke Group
Ebbinghaus Group
Hohm Group
Jacob Group
Maul Group
Walla Group

Associated Groups
Muñoz Group (GRS)

Emeriti
Becker Group
Gericke Group

Former Groups
Acuna Group
Elstner Group
Grohmann Group
Neugebauer Group
Tinnefeld Group

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P. O. Box 3329, 38023 Braunschweig
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