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Ingredient dispersity
  • Current research projects
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    • [Translate to English:] Zellmechanische Eigenschaften

Ingredient dispersity

Effects of active ingredient dispersity in polymer preparations in the melt-based, additive production of solid dosage forms

Funded by: BMWi

Contact person: Marius Tidau

Summary of the overall project:
A knowledge-based, model-supported development platform is to be created to fundamentally improve the understanding of process interplay and thus improve the production design and quality assurance in the processing of particle-loaded polymer melts into dosage forms. This should in particular help to understand the relationship between partially dissolved and particulate active ingredient, processability and product properties. Therefore, this project aims to generate basic material-structure-property knowledge by systematically evaluating the influence of disperse properties. This knowledge will be transferred to new active ingredients and polymers by describing the interrelationships in models. Thus, essential material parameters will be identified and used to make reliable predictions of manufacturing parameters, process limits and product properties. With the development platform created in the project, pharmaceutical product developers shall be enabled to rationally bring highly filled polymer-active substance preparations with desired properties to market maturity in a time- and cost-saving manner. Following the approval of additive manufacturing processes for drugs, SMEs (including pharmacies and CDOs), for whom the automated production of individualised drugs in small quantities is an attractive business area, will be able to use this knowledge advantage for their success. Beyond pharmaceutical applications, 3D printer manufacturers can transfer the results directly to existing applications with filled polymers in other business areas.

Goals and tasks of iPAT:

  • Selection and characterization of different polymer-API systems to establish material-specific process windows
  • Provision of an analytical toolbox for the characterization of the influences of the disperse API along the entire process chain
  • Compilation of model descriptions of the observed effects and derivation of a knowledge-based procedure guideline for the accelerated development of intermediate materials for the polymer melt-based additive production of dosage forms

 
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