Funded by: BMWi
Contact person: Marius Tidau
Summary of the overall project:
A knowledge-based, model-supported development platform is to be created to fundamentally improve the understanding of process interplay and thus improve the production design and quality assurance in the processing of particle-loaded polymer melts into dosage forms. This should in particular help to understand the relationship between partially dissolved and particulate active ingredient, processability and product properties. Therefore, this project aims to generate basic material-structure-property knowledge by systematically evaluating the influence of disperse properties. This knowledge will be transferred to new active ingredients and polymers by describing the interrelationships in models. Thus, essential material parameters will be identified and used to make reliable predictions of manufacturing parameters, process limits and product properties. With the development platform created in the project, pharmaceutical product developers shall be enabled to rationally bring highly filled polymer-active substance preparations with desired properties to market maturity in a time- and cost-saving manner. Following the approval of additive manufacturing processes for drugs, SMEs (including pharmacies and CDOs), for whom the automated production of individualised drugs in small quantities is an attractive business area, will be able to use this knowledge advantage for their success. Beyond pharmaceutical applications, 3D printer manufacturers can transfer the results directly to existing applications with filled polymers in other business areas.
Goals and tasks of iPAT: