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Drying and tableting of living microorganisms
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    • [Translate to English:] Zellmechanische Eigenschaften

Drying and tableting of living microorganisms

Process-specific stress types in the production of probiotic tablets and their influence on the viability of the embedded microorganisms.

Sponsor: DFG

Contact person: Karl Vorländer

Summary of the overall project:

The investigation of the influence of formulating and processing microorganisms on their survival is of particular interest in the context of developing probiotic dosage forms. Probiotic microorganisms interact with the human microbiome and have a positive effect on the health of the patient. For this, the viability of the administered microorganisms is crucial. Different stresses occur during the manufacturing process, caused by temperature and concentration changes as well as mechanical stress. The production of dry dosage forms such as powders or tablets is preferred to liquid or semi-solid products due to their better shelf life and acceptance. However, the drying of microorganisms is usually accompanied by a considerable reduction of the cell viability. Different methods are developed and used to characterize cell viability in order to determine the damage mechanisms in different drying processes and subsequent process steps. Systematic investigations of the influence of process steps as well as process and formulation parameters on the survival of microorganisms are used to scientifically elucidate and rationally design the entire process chain from cell cultivation to packaging of the final dosage form.

Goals and tasks of iPAT

  • Development of methods for the quantifying and qualifying characterization of stressed microorganisms
  • Investigation of cell damage in different drying processes and establishment of protection strategies
  • Tableting of dried microorganisms and characterization of the influence of formulation and process parameters
  • Storage stability tests
  • Derivation of models and rules for rational process design
Sprühgetrocknete Hefe

Figure: Spray dried yeast cells

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