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Model-based analysis of process chains for the manufacturing of solid pharmaceuticals using agent-based simulation
  • Current research projects
    • Confined high-load compression
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    • Scale Transfer in Pharmaceutical Compression
    • Die filling in rotary tablet presses
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    • Model-based analysis of process chains for the manufacturing of solid pharmaceuticals using agent-based simulation
    • pellets of filamentous microorganisms
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    • [Translate to English:] Zellmechanische Eigenschaften

Model-based analysis of process chains for the manufacturing of solid pharmaceuticals using agent-based simulation

Sponsor: DFG

Contact person: Lukas Bahlmann

Summary of the overall project:

The transition from batch to continuous processes in the pharmaceutical industry offers benefits, but also challenges. In particular, given the high quality requirements, the absence of defined batches in continuous production means that other measures must be used to ensure effective quality assurance. For example, cyber-physical production systems (CPPS) can be used as digital twins of production processes to support process design, quality assurance and energy efficiency during operation. However, this requires a deep understanding of both the individual processes and the entire process chain. In this research project, an agent-based simulation of continuous granulation will be developed based on mechanistic models and simulation approaches. The process of continuous ring layer granulation, which has received little scientific attention to date, will be investigated and fundamentally characterized. Process data will be collected using a variety of in-line sensors and mechanistic models for granulation will be determined using process-structure-property relationships, which will be used to build the simulation. The agent-based simulation will then be integrated into a CPPS of the whole process chain, for which simulations for mixing and tableting are already available from the previous project.

Goals and tasks of iPAT:

  • Basic experimental characterization of the continuous ring layer granulation process using various inline sensors (microscopic particle size measurement, UV-Vis spectroscopy, NIR spectroscopy). 
  • Development of a mechanistic model for ring layer granulation based on process-structure-property relationships Cross-scale validity of the models for rotary presses on an industrial scale
  • Evaluation of agent-based simulation approaches developed at IWF

 

Project partner: Institute of Machine Tools and Production Technology (IWF)

Grafik_Projektbeschreibung_LuB

Fig.: Flow chart of the continuous granulation and drying system Granucon®1 from Lödige used in this project.

 

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