Funded by: F. Hoffmann-La Roche Ltd
Contact person: Hasti Ghanadimaragheh
Summary of the overall Project:
Tablet surface defects, such as sticking and picking, result in significant challenges in pharmaceutical manufacturing. Sticking occurs when small amounts of formulation adhere to the tablet punches during compression. Picking, a specific form of sticking, takes place when material sticks in the embossed area of punches. These tablet surface defects not only compromise aesthetic quality, potentially undermining patient confidence, but also lead to dosage variability, excessive material waste, and unplanned process down-times for cleaning.
Numerous factors including punch geometry and coating, environmental conditions, material properties, and process parameters can influence sticking/picking phenomena during tableting. Whitin this project, a phase-appropriate risk assessment methodology will be developed to predict the risk for sticking/picking in tableting processes along the product development life cycle.
Goals and tasks at iPAT: