Nano Tab

Nanostructured carrier systems with controllable drug release for individualised tablets [NanoTab]

Sponsor: Deutsche Forschungsgemeinschaft (DFG)

Contact person : Manuel Heck

Summary of the overall project:

The aim of the transfer project is to produce tablets with customised drug release kinetics based on hierarchical silica aggregates with mesoporous properties by scaling up known manufacturing processes to pilot scale. Additional mass transport modelling will enable the targeted adaptation of drug release to specific release profiles of tablets, which can then be transferred to different particulate systems and active ingredients. The Institute for Particle Technology is collaborating with the Fraunhofer IST and the companies Pharma Test Apparatebau AG and Tantec A/S on an interdisciplinary basis in order to realise the goals and challenges involved in the scale-up of a suitable process chain for the production of patient group-specific, adaptable drug carrier systems.

Goals and tasks of iPAT:

• Investigation of the production of aggregate structures with defined drug release profiles and their application for pharmaceutical formulations
• Production of tablets with specifically adjustable release kinetics
• In-process characterisation and mass transport modelling to evaluate different release profiles and identify suitable drug carrier system structures

Project partners:
Fraunhofer IST, Pharma Test Apparatebau AG, Tantec A/S