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Modelling of hierarchical structure formation during spray drying via CFD-DEM coupling and continuous species transport
  • Current research projects
    • GraphenMEX
    • IntelliPast
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    • Modelling of hierarchical structure formation during spray drying via CFD-DEM coupling and continuous species transport
    • opus fluidum futurum
    • Simulation of mechanochemical processes in mills
    • SPP 2289 Hetero-Aggregates

Modelling of hierarchical structure formation during spray drying via CFD-DEM coupling and continuous species transport

Funding organisation: DFG (Middle East Collaboration)

Contact Person: Silas Wolf

Summary of the overall project:

Particle and aggregate structures in the micro- and nanometer range are fundamental to products in the analytical, chemical, biotechnological and pharmaceutical fields. Porous systems tailored from particles are used in chromatographic purification, catalytic processes and as carriers for the controlled release of pharmaceutical active ingredients. System characteristics depend on material properties and the underlying particle or aggregate structure. Processing steps, including formulation, have a significant impact on the structure and technical properties. The key question is how to structure aggregate systems for different applications to optimise mass transport and maintain mechanical stability. Previous projects have investigated aggregate systems via spray drying from nanoparticulate suspensions.

 

This project aims to establish CFD-DEM simulations to understand particle-scale structure formation, in particular hierarchical structures in the initial drying stage. Simultaneously, a modelling approach by Prof. Avi Levy's group at Ben-Gurion University of the Negev, Israel will consider multiple particle sizes and interactions in both drying stages. The CFD-DEM results will efficiently support the model development. This integrated approach will allow the influence of different process and formulation conditions on the product to be explored. Ultimately, the models should enable efficient process optimisation and predict structure formation during spray drying.

Goals and tasks of iPAT

  • Simulation of the drying of a single suspension droplet using CFD-DEM coupling
  • Development of improved methods for visualising evaporation and droplet shape
  • Investigation of hierarchical structure formation during spray drying
  • Support of the alternative modelling approach (continuous species transport)
  • Characterisation of spray-dried aggregates to validate the models

 

Project partner: Prof Avi Levy working group (Ben-Gurion University of the Negev, Israel)

Modellierung der hierarchischen Strukturbildung bei der Sprühtrocknung mittels CFD-DEM-Kopplung und Continuous-Species-Transport

Fig.: Schematic representation of the project plan

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