Doctoral candidate
Pharmacist
Contact
Institut für Pharmazeutische Technologie und Biopharmazie
Technische Universität Braunschweig
Mendelssohnstraße 1
38106 Braunschweig
E-Mail: antonia.hinze@tu-braunschweig.de
Room: 139
Telephone: +49 531 391-5719
Field of work
Modulation of tight junctions to increase the bioavailability of drugs
Modern methods of drug development are used to identify potential drugs with high throughput. These are often assigned to BCS classes III or IV due to poor permeability properties and are therefore hardly absorbed into the body or into certain compartments of the body. One approach to increase the epithelial or endothelial permeability and thus achieve a sufficiently high bioavailability of the drug is to reduce the paracellular barrier by the targeted use of mechanism-based tight junction modulators [1-4]. The aim of this work is to identify and characterize potential tight junction modulators and to evaluate the activity of tight junction modulators by developing a new assay that is optically qualifiable and quantifiable.
References
[1] Saaber, Daniel; Wollenhaupt, Sabrina; Baumann, Knut; Reichl, Stephan (2014): Recent progress in tight junction modulation for improving bioavailability. In: Expert opinion on drug discovery 9 (4), S. 367–381. DOI: 10.1517/17460441.2014.892070.
[2] Saaber, Daniel; Reichl, Stephan (2019): A unified in vitro test system for the assessment of tight junction modulators. In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 142, S. 353–363. DOI: 10.1016/j.ejpb.2019.07.004.
[3] Brunner, Joël; Ragupathy, Sakthikumar; Borchard, Gerrit (2021): Target specific tight junction modulators. In: Advanced drug delivery reviews 171, S. 266–288. DOI: 10.1016/j.addr.2021.02.008.
[4] Ramirez-Velez, Isabela; Belardi, Brian (2023): Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery. In: Advanced drug delivery reviews 199, S. 114905. DOI: 10.1016/j.addr.2023.114905.