Magnetic Measurement and Imaging Technology (MMIT)

DFG Project: "Sensitive mix-and-measure magnetic immunoassay for SARS-CoV-2 virus detection: towards benchtop point-of-need diagnostics
(10/2022 - 09/2025)

This project aims to develop a low-cost, highly sensitive, and easy-to-use virus detection system using magnetic particle spectroscopy (MPS) and antibody-conjugated magnetic nanoparticles. The method enables quantitative, rapid diagnostics directly from patient samples (e.g., saliva) using a compact benchtop device. By combining materials science, biology, and engineering, the team creates a robust platform for accurate virus detection beyond SARS-CoV-2, suitable for large-scale screening and pandemic preparedness.

GradKolleq: "Applied research on RNA-based agents in medical and pharmaceutical technology (RNApp)"
(08/2024 - 07/2027)

Subproject A4: "Targeted ncRNA Delivery Using Thermo-Responsive Magnetic Nanoparticles (SPIONs)"
This project explores the therapeutic potential of superparamagnetic iron oxide nanoparticles (SPIONs) as organ-specific carriers for ncRNA therapeutics. By coupling ncRNA drugs to SPIONs via thermo-sensitive linkers, targeted release can be triggered through localized magnetic heating, monitored by magnetic particle imaging (MPI). This approach aims to overcome off-target effects common in lipid-based delivery systems and enhance treatment precision for fibrotic lung tissue. The project includes nanoparticle development, release studies, toxicity evaluation, and in vivo efficacy testing in mouse models in close collaboration with Hannover Medical School (MHH).

DFG Project: "Localized cardiac ncRNA therapy via imaging-controlled magnetic nanoparticle delivery
(11/2025 - 10/2028)

This project is developing a new method for targeted and controlled drug delivery to the heart. At its core is a customized magnetic nanoparticle drug delivery agent (DDA) carrying LNA-21, which inhibits the pro-fibrotic microRNA-21. Guided by imaging, the nanoparticles can be precisely activated at the target site to release the drug. By locally blocking miR-21, the therapy aims to reduce cardiac fibrosis, preserve heart function, and slow the progression of heart disease while minimizing side effects.

BMBF Project 13GW0790E: "Induktiv modulierbarer patientenindividueller Sehnenersatz (MagTen)"
(01/2026 - 12/2028)

MagTen is a novel, patient-specific tendon implant that combines 3D-printed biphasic metamaterials with non-invasive magnetic modulation. It mimics natural tendon-to-bone transitions and allows post-surgical adjustment of mechanical properties via integrated nanoparticles. This approach improves healing outcomes, avoids preparatory surgeries, and supports faster, more effective rehabilitation.

1. Marion Görke, Sherif Okeil, Guohui Yang, Hermann Nirschl, Thilo Viereck, Georg Garnweitner: The role of superlattice phases and interparticle distance in the magnetic behaviour of SPION thin films, Nanoscale 17(21), 13466–13476, 2025. doi: 10.1039/D5NR00973A

2. Rebecca Sack, Joshua Evans, Florian Wolgast, Meinhard Schilling, Thilo Viereck, Petr Šulc, Aidin Lak: Mismatch-Assisted Toehold Exchange Cascades for Magnetic Nanoparticle-based Nucleic Acid Diagnostics, JACS Au 5(9), 4611–4624, 2025. doi: 10.1021/jacsau.5c00985

3. Marion Görke, Daesung Park, Sherif Okeil, Thilo Viereck, Georg Garnweitner: Tuning Elemental Distribution in FePt Nanoparticles through Ligand Ratio Variation, Crystal Growth & Design 25(15), 6461–6467, 2025. doi: 10.1021/acs.cgd.5c00868