Group of Prof. Dr. Hermann Wätzig

Members: Finja Krebs, Kai Jorrit Maul, Mais Olabi, Dr. Imke Oltmann-Norden, Dr. Lutz Preu, Christin Scheller, Matthias Stein, Rebecca Wiesner, Holger Zagst

Gruppenfoto AK Wätzig
Photo credit: Annika Timm/TU Braunschweig

In close collaboration with pharmaceutical companies and national as well as European competent authorities we work on analytical topics, emphazising separation techniques, protein and proteome analysis, quality assurance of biotechnically produced pharmaceuticals and statistical issues from quality control.

Hence we employ capillary and gel electrophoresis (CE and SDS-PAGE, 2-DE), HPLC and mass spectrometry, we develop strategies to economically qualify analytical instrumentation, we optimize and validate methods, especially in order to improve precision and accuracy. In the last time we achieved percental relative standard deviations RSD% of approximately 1 to 2% for various analytical application of chromatography in bioanalysis (SEC, SAX, RP-LC), further we obtained similar numbers even for gel electrophoresis.

We work out concepts how to set specifications and how to use statistical process control (SPC) with the goal to facilitate the parametric release. Moreover trend test, data evaluation related to method transfers and outlier detection are related to this branch.

One recent research topic deals with affinity capillary electrophoresis (ACE). This is an efficient and precise possibility to study interactions in solutions. We use this approach to investigate specific interactions of proteins with e.g. metal ions or anions from organic acids. By this way we also like to better understand, how proteins influence their direct environment and how this is related to various mechanisms of biochemical regulation and to the efficacy of pharmaceuticals.

In this context we became generally interested in the analytical quality of Ligand Binding Assays (LBAs), that is in their precision and accuracy and in the related optimization strategies. In addition to ACE, we also practically employ Surface Plasmon Resonance (SPR) analysis.

Are you interested in a collaboration in one of these fields? We are looking forward to hear from you:

contact:

Prof. Dr. Hermann Wätzig 
Institute for Medicinal and Pharmaceutical Chemistry 
38106 Braunschweig
Beethovenstr. 55
Phone: +49-531 - 391 2764 or 391 2751
Fax.: +49-531 - 391 2799
h.waetzig(at)tu-bs.de

Short CV:

Prof. Dr. Hermann Wätzig studied pharmacy at the Freie Universität Berlin from 1981 to 1985. PhD thesis 1989 about an HPLC topic. From 1990 lecturer at the Institut für Pharmazie in Würzburg. Habilitation 1995. In 1999 appointment to a professorship in pharmaceutical chemistry at the Technical University of Braunschweig. Since 2001 chair of the division pharmaceutical analysis/quality control of the German Pharmaceutical Society.