The need for sustainable, efficient and reliable methods for the controlled release of drugs from dosage forms is continuously growing. For this challenging task different approaches are known in the literature, including the embedding of drugs in hydrogels. Such innovative systems enable the „smart“ delivery of bioactive molecules from drugs. Disadvantages of already existing intelligent hydrogels consist in low mechanical stability, limited and not completely reversible swelling capacity, and inert response to external stimuli. To improve these properties, novel hydrogels are to be synthesized, chemically modified and optimized as drug carriers in this research project. The aim is to achieve a selective drug release from hydrogels over a defined time period and at a specific location in order to control the duration of the action and to minimize undesired effects outside the site of action. The swelling property of a hydrogel is a significant factor for diffusion-controlled and chemically controlled releases and is investigated within this research project by varying various parameters. In addition to the high capacity for water storage, these materials show a different swelling and shrinking behavior in aqueous and organic media. This advantage should be used to achieve a targeted release of active ingredients („stimulus-responsive“) as a function of external influences, such as pH, temperature, light, pressure, etc. by targeted functionalization of the materials. In addition to the release profiles and the synthesis of novel hydrogels, structure-property relationships, biocompatibility, as well as cellular bio-distribution are investigated. In addition to the optimization of the reaction conditions, the range of application of the method is systematically examined. The synthesized hydrogels having the requested mechanical, biological and chemical properties will be investigated for a subsequent granulation and tableting process. In-vitro release systems in physiologically relevant media for the characterization of pharmaceutical properties, such as release and decay, are developed and established for a broad spectrum of active ingredients. In addition, a basic understanding of the new drugs and their interaction with the active ingredients will be developed. The synthesis of innovative human biocompatible drug carriers as drug delivery system for both drug systems and new medical products requires the adaptation of process technologies and the creation of technical-analytical methods for characterization. The processing of these novel materials also results in novel process-related possibilities in the production of the pharmaceutical carriers, such as new plant-reactor concepts and automation possibilities. Temperature-controlled test environments for swellable moulded bodies and suitable media should be found in order to determine the types of controllable drug release by various stimuli, e.g. of the temperature.