The fascinating chemistry of boron is the central focus of our research. We are interested in novel bonding situations (e. g. multiple bonds) or reactivities of this inspiring chemical element. The compounds achieved are subject to a broad range of applications including substrate activation, boron-containing ligands for metal complexes and photo responsive compounds.
Image: Application of tailor-made biocatalysts in pilot scale for enzymatic production of high value sugar, isomaltose from sucrose
Our main research interest is biocatalysis: screening, characterization and application of carbohydrate enzyme to produce high value sugars, functional food and sugar substitute (prebiotics, dietary fibers and alternative sweeteners).
Bild: Blick in die Probenkammer des Röntgen-Photoelektronenspektrometers (XPS), das zum Beispiel in Charakterisierung von Polymerfilmen für die Biomedizintechnik genutzt wird.
In vielen Anwendungen von optischen Elementen bis hin zu biomedizinischen Anwendungen können ultradünne Polymerbeschichtungen die Eigenschaften eines Materials ganz wesentlich bestimmen. Wir synthetisieren Polymere und charakterisieren die Beschichtungen, um z.B. die Biokompatibilität eines Implantatmaterials entscheidend zu verbessern.
Tea constituents, such as phenolic compounds, foremost flavonoids as well as phenolic acids (in tea and coffee) and amino acids. Studies on contaminants like nicotine in tea or food borne toxins like acrylamide or furan and methylfurans. Methods in focus are chromatography (HPLC, UHPLC, often hyphenated to mass spectrometers, GC and GC-MS).
Why does one methylcellulose gel at 58 ⁰C, another one at 35 ⁰C? Why does one methylcellulose form a clear solution, while the other does not? Such differences in properties of putatively equal polysaccharide derivatives which, for instance, provide the required consistence in vegetarian sausages, are caused by their structure. And this structure is not uniform, but a combination of complex patterns and distributions which need to be analyzed as detailed as possible. Our work in the field of carbohydrate analysis is aimed at solving these questions. In doing so, quantitative mass spectrometry plays a central role.
Ebbinghaus Group - Biophotonics
Image: Cell sample under a fluorescence microscope for the examination of proteins in living cells
Biopolymers such as proteins, DNA and RNA are optimized for their function in living cells. This environment differs in many aspects from aqueous buffer solutions in which they are usually examined, for example by high-throughput screening in the pharmaceutical industry. Our group uses spectroscopy and microscopy to observe biomolecules directly inside cells and thus obtain innovative knowledge about their function and possible malfunction. Based on this, we develop new drugs for a variety of diseases.