How Does Alzheimer’s Disease Begin?

"Deep is the well of the past. Should it not be called unfathomable?" (Thomas Mann)

Alzheimer’s disease is one of the most complex and protracted diseases of the human brain. Especially the onset of the disease proves to be extremely difficult to study. This is 15 to 30 years before patients become clinically conspicuous due to cognitive deficits, especially in the areas of language and memory. It is known that a disturbed calcium balance in neurons is present at the beginning of Alzheimer’s disease and probably contributes to the early memory failures. Professor Martin Korte and his team at the Technische Universität Braunschweig have shown in a study how the calcium balance gets out of control. The results have just been published in the journal “PNAS”.

Involved BRICS research group: Prof. Dr. Martin Korte

Press release TU Braunschweig