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Logo Institut für Pharmazeutische Technologie und Biopharmazie der TU Braunschweig
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X-ray examinations

The Institute of Pharmaceutical Technology and Biopharmaceutics is equipped with small angle diffraction, small angle scattering and wide angle diffraction devices. This enables us to offer a broad range of services like stability testing, structural analysis in context with patented modifications or in process controls.

Liberation and permeation studies

Drug liberation from its formulation and permeation studies can be performed using both excised human skin, excised stratum corneum and skin or cornea equivalents. By this means the ideal formulation for a dermal or ocular application can be found out.

Cultivation of three-dimenstional organotypic skin and cornea equivalents for in vitro use

With a view to minimise animal experiments skin and cornea equivelents are useful as permeation barriers or for the examination of cytotoxicity.

Examination of cytotoxicity

Cytotoxicity of drugs and excipients is examined with cultures of epidermal and dermal cells. These examinations supplement the results of other compatibility tests.

Particle size measurements

Microscopy with digital image processing and optical methods based on scattering and diffraction of light are available. The Institute of Pharmaceutical Technology and Biopharmaceutics features devices like Malvern Master- and Zetasizer, BeckmanCoulter LS 13320 with PIDS technology and ECA (Emulsion Characteristics Analyzer). The latter provides a measurement without dilution of the sample.

Stability of ointments, creams and emulsions

Based on an AiF project an assay for the stabilty testing of ointments, creams and emulsions has been developed. The Institute of Pharmaceutical Technology and Biopharmaceutics performs those studies by orders of companies that do not feature the necessary equipment and consults them with the development of a competitive product.

Transmissionelectronmicroscopy (TEM)

The submicroscopic structure of formulations can be visualised by TEM. The images provide conclusions about the frameworks of ointments and creams or the stability of an emulsion. Other colloidal structures of different size like liposomes and their multilamelar layers can be identified as well. Thus the TEM is a valuable tool for stability examinations.

Headspaceanalytics

Characteristic odour spectra of samples can be measured by means of conductivity.

Spray drying

Aqueous systems can be dried by spray drying with an output of 3 l/h and 10 l/h. The spray drier is available for scaling up studies.

Fluidised bed granulation

A fluidised bed granulator with a capacity of 3 kg is available for scaling up studies.

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P. O. Box: 38092 Braunschweig
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Phone: +49 (0) 531 391-0

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