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pellets of filamentous microorganisms
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    • [Translate to English:] Zellmechanische Eigenschaften

pellets of filamentous microorganisms

Investigation and modelling of mechanical and surface-induced stress of pellets of filamentous microorganisms on the example of Lentzea aerocolonigenes

Sponsor: DFG

Contact person: Marcel Schrader

Summary of the overall project:

This project is part of the DFG priority programme DiSPBiotech (SPP 1934), which research is focused on dispersity-, structural- and phase-changes of proteins and biological agglomerates in biotechnological processes. Especially filamentous microorganisms are widely used by the industrial biotechnology for the production of chemical and pharmaceutical substances. The morphology of these microorganisms ranges, dependent on the process parameters (e.g. pH-value, cultivation media composition, mechanical stress, inoculum concentration), from loose mycelium to highly branched pellets. This project investigates the effect of micro- (<30 µm) and macro-particle (up to 5 mm) addition on the morphology and the linked productivity of the filamentous actinomycetes Lentzea aerocolonigenes. The application of both particle types showed already significantly increased concentrations of the antibiotic Rebeccamycin, apperently due to different phenomena: physico-chemical surface effects when micro-particles were added and mechanical stress when macro-particles were supplemented to the cultivation batch. By linking experiments and simulation, the underlying mechanisms of action are to be identified and quantified in order to build empirical-mechanistic models.

Goals and tasks of iPAT

  • Quantification of the mechanical stress energy and stress frequency on the macro scale (shake flask/ bioreactor) by using multiphase simulations (CFD-DEM coupling)
  • Measurement of micro-mechanical properties of single pellets and hyphae
  • Investigation of dispersity- and structural changes of pellets under mechanical stress by using DEM simulations of resolved pellet structures
  • Modelling of dispersity- and structural changes of pellets for population balance models
  • Chemical surface modifications of micro-particles and the characterization of the physico-chemical microorganism-particle-interactions

 

Project partners:Chair of Process Systems Engineering, TUM; Chemical & Process Engineering Dept., TU Berlin; Chair of Measurement and Control, TU Berlin; Dept. Applied and Molecular Microbiology

CFD-DEM-Simulation eines Schüttelkolbens mit Glaskugeln
Darstellung der Beanspruchung eines Pellets
Pelletschnitt mit Mikropartikelkern

Fig. : CFD-DEM-Simulation of a shake flask with glass beads (left); illustration of a pellet-glass-bead collision (middle); pellet slice with a micro-particle core (right)

 

 

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