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  • Drug Discovery and Cheminformatics for New Anti-Infectives (iCA)
Logo Zentrum für Pharmaverfahrenstechnik der TU Braunschweig
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Doctoral Theses

Individual Projects

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25.03.2022

Project iCA_10-01_2020: Structure based anti-infective discovery using Machine Learning

In this project, we aim to computationally optimise inhibitors for the enzyme DXS from the MEP

pathway. This enzyme is essential for the biosynthesis…

25.03.2022

Project iCA_11-01_2020: Organometallic Anti-infectives as Inhibitors of Thioredoxine or Trypanothione Reductase

Over the last 30 years, a demand for new antibacterial agents has grown significantly following concerns about antibiotic resistant bacteria (ARB).…

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25.03.2022

Project iCA_13-01_2020: Polycationic Oligomers as Lead Structures for new Anti-Infectives for the Treatment of Acanthamoeba Keratitis

The focus of my project is the development of new anti-infectives against a type of protists belonging to the genus Acanthamoeba, which are known to…

25.03.2022

Project iCA_14-01_2020: High-content screening and determination of the pharmacokinetics of potential biofilm inhibitors from fungi

Bacterial infections pose new challenges for medicine. In addition to the marked increase in the antibiotic resistance, it is the growth in so-called…

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25.03.2022

Project iCA_15-01_2020: Carboxylate functionalized N-heterocyclic Carbene Complexes as Anti-Infectives

Drug discovery relying on natural product compounds and gold complexation is my main job in this project. Nowadays, the synthesis of new drugs is an…

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