Dr.-Ing. Thilo Viereck

2024

Amplification- and Enzyme-Free Magnetic Diagnostics Circuit for Whole-Genome Detection of SARS-CoV-2 RNA
Enja Laureen Rösch, Rebecca Sack, Mohammad Suman Chowdhury, Florian Wolgast, Margarete Zaborski, Frank Ludwig, Meinhard Schilling, Thilo Viereck, Ulfert Rand, Aidin Lak
Chembiochem. 2024 May 6:e202400251
doi: 10.1002/cbic.202400251

Cooperative dynamics of DNA-grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami
Aidin Lak, Yihao Wang, Pauline J. Kolbeck, Christoph Pauer,  Mohammad Suman Chowdhury, Marco Cassani, Frank Ludwig, Thilo Viereck, Florian Selbach, Philip Tinnefeld, Meinhard Schilling, Tim Liedl, Joe Tavacolib,  Jan Lipfert
Nanoscale, 16, 7678-7689 - 2024
doi: 10.1039/D3NR06253H

Improvements of magnetic nanoparticle assays for SARS-CoV-2 detection using a mimic virus approach
Tamara Kahmann, Florian Wolgast, Thilo Viereck, Meinhard Schilling, Frank Ludwig
Sensing and Bio-Sensing Research, Volume 44, id.100654 - 2024
doi: 10.1016/j.sbsr.2024.100654

Integrated hyperthermia and magnetic particle imaging system for localized drug-release
Thilo Viereck, Kai Luenne, Meinhard Schilling, Frank Ludwig
International Journal on Magnetic Particle Imaging, Vol. 10 No. 1 Suppl 1 - 2024
https://www.journal.iwmpi.org/index.php/iwmpi/article/view/723

Sparse-representation-based image reconstruction for magnetic particle imaging
Shijie Sun, Yaoyao Chen, Klaas-Julian Janssen, Thilo Viereck, Meinhard Schilling, Frank Ludwig, Lijun Xu, Jing Zhong
in IEEE Transactions on Instrumentation and Measurement, vol. 73, pp. 1-9, 2024, Art no. 6001209
doi: 10.1109/TIM.2023.3332394

Towards sensitive Magnetic Particle Spectroscopy-based immunoassays with adjustable DC offset fields
Florian Wolgast, Eike Wendt, Frank Ludwig, Meinhard Schilling, Thilo Viereck
International Journal on Magnetic Particle Imaging IJMPI, Vol. 10 No. 1 Suppl - 2024
https://www.journal.iwmpi.org/index.php/iwmpi/article/view/732

2023

Decoupling the Characteristics of Magnetic Nanoparticles for Ultrahigh Sensitivity
Mohammad Suman Chowdhury, Enja Laureen Rösch, Daniel Arenas Esteban, Klaas-Julian Janssen, Florian Wolgast, Frank Ludwig, Meinhard Schilling, Sara Bals, Thilo Viereck, and Aidin Lak
Nano Letters 2023 23 (1), 58-65
https://doi.org/10.1021/acs.nanolett.2c03568

Functional magnetic nanoparticles: from synthesis design to in-depth characterization and nano-labelling for ultrasensitive magnetic biosensing
Rebecca Sack, Mayiz Zgheib, Mohammad Suman Chowdhury, Yihao Wang, Frank Ludwig, Meinhard Schilling, Thilo Viereck, Aidin Lak
IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers), Sendai, Japan, 2023, pp. 1-2
doi: 10.1109/INTERMAGShortPapers58606.2023.10228506

Low-cost standalone magnetic particle spectroscopy device for fast and sensitive immunoassays
Florian Wolgast, Tamara Kahmann, Meinhard Schilling, Frank Ludwig, Thilo Viereck
International Journal on Magnetic Particle Imaging IJMPI 9 (1 Suppl 1) - 2023

Role of ionic surfactant in magnetic dynamics of self-assembled dispersions of nanoplatelets
Hajnalka Nádasi, Melvin Küster, Alenka Mertelj, Nerea Sebastián, Patricija Hribar Boštjančič, Darja Lisjak, Thilo Viereck, Margaret Rosenberg, Alexey O. Ivanov, Sofia S. Kantorovich, Alexey Eremin, Frank Ludwig
J. Mol. Liqu. 382, 121900 - 2023
https://doi.org/10.1016/j.molliq.2023.121900

Towards simultaneous imaging of temperature and concentration with single-harmonic-based narrowband MPI
Klaas-Julian Janssen, Jing Zhong, Thilo Viereck, Meinhard Schilling, Frank Ludwig
International Journal on Magnetic Particle Imaging IJMPI 9.1 Suppl 1 (2023)

2022

Amplification and extraction free quantitative detection of viral nucleic acids and single-base mismatches using magnetic signal amplification circuit
Enja Laureen Rösch, Rebecca Sack, Mohammad Suman Chowdhury, Florian Wolgast, Meinhard Schilling, Thilo Viereck, Aidin Lak
bioRxiv, 2022.12. 24.521858 - 2022
doi: 10.1101/2022.12.24.521858

Quantitative temperature visualization with single harmonic-based magnetic particle imaging
Klaas-Julian Janssen, Jing Zhong, Thilo Viereck, Meinhard Schilling, and Frank Ludwig
J. Magn. Magn. Mater. 563, 169915 - 2022
https://doi.org/10.1016/j.jmmm.2022.169915

2021

Dependence of biomolecule detection on magnetic nanoparticle concentration
Jing Zhong, Klaas-Julian Janssen, Sebastian Draack, Thilo Viereck, Meinhard Schilling, Frank Ludwig
Journal of Magnetism and Magnetic Materials, Volume 517, 167408 - 2021
https://doi.org/10.1016/j.jmmm.2020.167408

Dynamic gelation process observed in Cartesian magnetic particle imaging
Sebastian Draack, Frank Ludwig, Meinhard Schilling, Thilo Viereck
Journal of Magnetism and Magnetic Materials, Volume 522, 167478, - 2021
https://doi.org/10.1016/j.jmmm.2020.167478

Estimation of the effective magnetic anisotropy constant of multi-core based magnetic nanoparticles from the temperature dependence of the coercive field
Keiji Enpuku, Ahmed L. Elrefai, Takashi Yoshida, Tamara Kahmann, Jing Zhong, Thilo Viereck, Frank Ludwig
J. Appl. Phys. 127, 133903 - 2020
https://doi.org/10.1063/1.5144713

Magnetic particle imaging of particle dynamics in complex matrix systems
Sebastian Draack, Meinhard Schilling, Thilo Viereck
Physical Sciences Reviews.
http://dx.doi.org/10.1515/psr-2019-0123

Point-of-need detection of pathogen-specific nucleic acid targets using magnetic particle spectroscopy
Enja Laureen Rösch, Jing Zhong, Aidin Lak, Zhe Liu, Markus Etzkorn, Meinhard Schilling, Frank Ludwig, Thilo Viereck, Birka Lalkens
Biosensors and Bioelectronics, Volume 192 - 2021
https://doi.org/10.1016/j.bios.2021.113536

Toward Rapid and Sensitive Detection of SARS-CoV-2 with Functionalized Magnetic Nanoparticles
Jing Zhong, Enja Laureen Rösch, Thilo Viereck, Meinhard Schilling, Frank Ludwig
ACS Sensors 2021 6 (3), 976-984 -2021
https://pubs.acs.org/doi/10.1021/acssensors.0c02160

2019

A novel characterization technique for superparamagnetic iron oxide nanoparticles: The superparamagnetic quantifier, compared with magnetic particle spectroscopy
Melissa M. van de Loosdrecht, Sebastian Draack, Sebastiaan Waanders, Jeroen Gerardus Leonard Schlief, Hendrikus Johannes Gradus Krooshoop, Thilo Viereck, Frank Ludwig, Bennie ten Haken
Rev. Sci. Instrum., Volume 90, page 024101 (1-9) - 2019
https://doi.org/10.1063/1.5039150

Biophysical Characterization of (Silica-coated) Cobalt Ferrite Nanoparticles for Hyperthermia Treatment
Niklas Lucht, Ralf P. Friedrich, Sebastian Draack, Christoph Alexiou, Thilo Viereck, Frank Ludwig, Birgit Hankiewicz, Nanomaterials 2019, 9, 1713.
https://doi.org/10.3390/nano9121713

Effect of core size distribution on magnetic nanoparticle harmonics for thermometry
Zhongzhou Du, Yi Sun, Oji Higashi, Yuki Noguchi, Keiji Enpuku, Sebastian Draack, Klaas-Julian Janssen, Tamara Kahmann, Jing Zhong, Thilo Viereck, Frank Ludwig, Takashi Yoshida
Japanese Journal of Applied PhysicsVolume 59, Number 1, 010904
https://doi.org/10.7567/1347-4065/ab5c9b

Effect of core size distribution on magnetic nanoparticle harmonics for thermometry
Zhongzhou Du, Yi Sun, Oji Higashi, Yuki Noguchi, Keiji Enpuku, Sebastian Draack, Klaas-Julian Janssen, Tamara Kahmann, Jing Zhong, Thilo Viereck
Japanese Journal of Applied PhysicsVolume 59, Number 1, 010904
https://doi.org/10.7567/1347-4065/ab5c9b

Multi-spectral Magnetic Particle Spectroscopy for the investigation of particle mixtures
Thilo Viereck, Sebastian Draack, Meinhard Schilling, Frank Ludwig
J. Magn. Magn. Mater., Volume 475, page 647--651 - 2019
https://doi.org/10.1016/j.jmmm.2018.11.021

Multiparametric Magnetic Particle Spectroscopy of CoFe₂O₄ Nanoparticles in Viscous Media
Sebastian Draack, Niklas Lucht, Hilke Remmer, Michael Martens, Birgit Fischer, Meinhard Schilling, Frank Ludwig, Thilo Viereck
J. Phys. Chem. C, 123 (11), pages 6787–6801 - 2019
DOI: 10.1021/acs.jpcc.8b10763

2018

Magnetic Relaxation of Agglomerated and Immobilized Iron Oxide Nanoparticles for Hyperthermia and Imaging Applications
Ulrich Michael Engelmann, Eva Miriam Buhl, Sebastian Draack, Thilo Viereck, Frank Ludwig, Thomas Schmitz-Rode, Ioana Slabu
IEEE Magnetics Letters, Volume 9, page 1507305 (5pp) - 2018
https://doi.org/10.1109/LMAG.2018.2879034

Modeling the Impedance of Water-Cooled Core-Less Multi-Layered Solenoid Coils for MPI Drive Field Generation
Christian Kuhlmann, Sebastian Draack, Thilo Viereck, Meinhard Schilling, Frank Ludwig
Internat. Journal on Magnetic Particle Imaging, Volume 4, Number 1, page 1--9 - 2018
http://dx.doi.org/10.18416/ijmpi.2018.1804001

2017

Dual-frequency magnetic particle imaging of the Brownian particle contribution
Thilo Viereck, Christian Kuhlmann, Sebastian Draack, Meinhard Schilling, Frank Ludwig
J. Magn. Magn. Mater., Volume 427, page 156--161 - 2017
http://dx.doi.org/10.1016/j.jmmm.2016.11.003

Effect of alignment of easy axes on dynamic magnetization of immobilized magnetic nanoparticles
Takashi Yoshida, Yuki Matsugi, Naotaka Tsujimara, Teruyoshi Sasayama, Keiji Enpuku, Thilo Viereck, Meinhard Schilling, Frank Ludwig
J. Magn. Magn. Mater., Volume 427, page 162--167 - 2017
http://dx.doi.org/10.1016/j.jmmm.2016.10.040

Size analysis of single-core magnetic nanoparticles
Frank Ludwig, Christoph Balceris, Thilo Viereck, Oliver Posth, Uwe Steinhoff, Helena Gavilan, Rocio Costo, Maria del Puerto Morales Lunjie Zeng, Eva Olsson, Christian Jonasson, Christer Johansson
J. Magn. Magn. Mater., Volume 427, page 19--24 - 2017
http://dx.doi.org/10.1016/j.jmmm.2016.11.113

Temperature-dependent MPS measurements
Sebastian Draack, Thilo Viereck, Christian Kuhlmann, Meinhard Schilling, Frank Ludwig
Internat. Journal on Magnetic Particle Imaging, Volume 3, Number 1 - 2017
http://dx.doi.org/10.18416/ijmpi.2017.1703018

2016

Magnetic Particle Imaging Applications of magnetic nanoparticles for analytics and imaging
Thilo Viereck
Dissertation TU Braunschweig, ISBN: 978 3 86387 739 2
http://www.digibib.tu-bs.de/?docid=00064032

2015

Debye-Based Frequency-Domain Magnetization Model for Magnetic Nanoparticles in Magnetic Particle Spectroscopy
Thilo Wawrzik, Takashi Yoshida, Meinhard Schilling, Frank Ludwig
IEEE Trans Magn. 51, 5300404, 2015
doi: 10.1109/TMAG.2014.2332371

Drive-field frequency dependent MPI performance of single-core magnetite nanoparticle tracers
Christian Kuhlmann, Amit P. Khandhar, Richard M. Ferguson, Scott J. Kemp, Thilo Wawrzik, Kannan M. Krishnan, Frank Ludwig
IEEE Trans. Magn. 51, 6500504, 2015
doi: 10.1109/TMAG.2014.2329772

Magnetic characterization of clustered core magnetic nanoparticles for MPI
Nicole Gehrke, David Heinke, Dietmar Eberbeck, Frank Ludwig, Thilo Wawrzik, Christian Kuhlmann, Briel Andreas
IEEE Trans. Magn. 51, 5300204, 2015
doi: 10.1109/TMAG.2014.2358275

Magnetic Particle Imaging Applications of magnetic nanoparticles for analytics and imaging
Thilo Viereck
Dissertation TU Braunschweig, ISBN: 978 3 86387 739 2
http://www.digibib.tu-bs.de/?docid=00064032

2014

Debye-based frequency-domain magnetization model for magnetic nanoparticles and its application to viscosity-dependent MPS measurements
T. Wawrzik, T. Yoshida, H. Remmer, C. Kuhlmann, M. Schilling, and F. Ludwig
IEEE Trans Magn. (2014)
http://dx.doi.org/10.1109/TMAG.2014.2332371

Drive-field frequency dependent MPI performamnce of single-core magnetite nanoparticle tracers
C. Kuhlmann, A. P. Kandhar, R. M. Ferguson, S. Kemp, T. Wawrzik, M. Schilling, K. M. Krishnan, and F. Ludwig
IEEE Trans. Magn. (accepted)

Dynamic magnetic properties of optimized magnetic nanoparticles for magnetic particle imaging
F. Ludwig, C. Kuhlmann, T. Wawrzik, J. Dieckhoff, A. Lak, A. P. Kandhar, R. M. Ferguson, S. J. Kemp, and K. M. Krishnan
IEEE Trans. Magn., Vol. 50, 5101804, 2014
DOI: 10.1109/TMAG.2014.2329504

Magnetic characterization of clustered core magnetic nanoparticles for MPI
N. Gehrke, D. Heinke, D. Eberbeck, F. Ludwig, T. Wawrzik, C. Kuhlmann, and A. Briel
IEEE Trans. Magn. (accepted)

Self-consistent magnetic properties of magnetite tracers optimized for magnetic particle imaging measured by ac susceptometry, magnetorelaxometry and magnetic particle spectroscopy
F. Ludwig, H. Remmer, C. Kuhlmann, T. Wawrzik, H. Arami, R. M. Ferguson, and K. M. Krishnan
in: J. Magn. Magn. Mater. 360, 169-173 (2014)

2013

A 3D MPI system for biological studies on mice
Christian Kuhlmann, Thilo Wawrzik, Frank Ludwig, Meinhard Schilling
International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, CA art.no. 6528373, IEEE XPlore - 2013
DOI:10.1109/IWMPI.2013.6528373

Characterization of magnetic nanoparticle systems with respect to their magnetic particle imaging performance
Frank Ludwig, Dietmar Eberbeck, Norbert Löwa, Uwe Steinhoff, Thilo Wawrzik, Meinhard Schilling, Lutz Trahms
Biomed Tech (Berl). 2013 Dec;58(6):535-45.
DOI: 10.1515/bmt-2013-0013

Effect of Brownian relaxation in frequency-dependent Magnetic Particle Spectroscopy measurements
Thilo Wawrzik, Christian Kuhlmann, Hilke Remmer, Nicole Gehrke, Andreas Briel, Meinhard Schilling, Frank Ludwig
International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, CA art.no. 6528371, IEEE XPlore - 2013
DOI: 10.1109/IWMPI.2013.6528371

Estimating particle mobility in MPI
Thilo Wawrzik, Christian Kuhlmann, Frank Ludwig, Meinhard Schilling
International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, CA art.no. 6528372, IEEE XPlore - 2013
DOI: 10.1109/IWMPI.2013.6528372

Magnetic Particle Imaging-Scanner with 10 kHz drive-field frequency  
Meinhard Schilling, Frank Ludwig, Christian Kuhlmann, Thilo Wawrzik
Biomedical Engineering - 2013
Biomed Tech (Berl). 2013 Dec;58(6):557-63.
DOI: 10.1515/bmt-2013-0014

Scanner setup and reconstruction for three-dimensional magnetic particle imaging  
Thilo Wawrzik, Christian Kuhlmann, Frank Ludwig, Meinhard Schilling
Proceedings of SPIE 8672, 86721B - 2013
DOI:10.1117/12.2006392

2012

Characterization of Magnetic Nanoparticles for Magnetic Particle Imaging by Magnetorelaxometry, AC Susceptibility, Magnetic Particle Spectroscopy and Static Magnetization Measurements
Frank Ludwig, Thilo Wawrzik, Meinhard Schilling
Magnetic Particle Imaging, Springer Proceedings in Physics, Volume 140, 35–40 - 2012

Characterization of Resovist nanoparticles for magnetic particle imaging
Takashi Yoshida, Keiji Enpuku, Frank Ludwig, Jan Dieckhoff, Thilo Wawrzik, Aidin Lak, Meinhard Schilling
Magnetic Particle Imaging, Springer Proceedings in Physics, Volume 140, 3–7 - 2012

Magnetic Particle Imaging: Exploring particle mobility
Thilo Wawrzik, Frank Ludwig, Meinhard Schilling
Magnetic Particle Imaging, Springer Proceedings in Physics, Volume 140, 16–23 - 2012

Optimization of magnetic nanoparticles for magnetic particle imaging
Frank Ludwig, Thilo Wawrzik, Takashi Yoshida, Nicole Gehrke, Andreas Briel, Dietmar Eberbeck, Meinhard Schilling
IEEE Trans. Magn., Volume 48, 3780–3783, 2012
DOI: http://dx.doi.org/10.1109/TMAG.2012.2197601

Perspectives of magnetic particle spectroscopy for magnetic nanoparticle characterization  
Thilo Wawrzik, Meinhard Schilling, Frank Ludwig
Magnetic Particle Imaging, Springer Proceedings in Physics, Volume 140, 41–45 - 2012

Synthesis of Single-Core Iron Oxide Nanoparticles as a Potential Tracer for Magnetic Particle Imaging
Aidin Lak, Thilo Wawrzik, Frank Ludwig, Meinhard Schilling
Magnetic Particle Imaging, Springer Proceedings in Physics, Volume 140, 91–95 - 2012

2010

Magnetic particle spectroscopy for the evaluation of eld-dependent harmonics generation
T. Wawrzik, J. Hahn, F. Ludwig and M. Schilling
Magnetic Nanoparticles – Particle Science, Imaging Technology, and Clinical Applications,
Proceedings of First International Workshop on Magnetic Particle Imaging, World Scientific 2010 (pp. 86–91)

Multivariate Magnetic Particle Spectroscopy for Magnetic Nanoparticle Characterization
T. Wawrzik, F. Ludwig and M. Schilling
AIP Conference Proceedings Vol. 1311, 267–270, 2010

Two-dimensional magnetic particle imaging
T. Wawrzik, F. Ludwig and M. Schilling
Magnetic Nanoparticles – Particle Science, Imaging Technology, and Clinical Applications, Proceedings of First International Workshop on Magnetic Particle Imaging, World Scientific 2010 (pp. 100–105)

2009

Assembly for One-dimensional Magnetic Particle Imaging
Thilo Wawrzik, Frank Ludwig, Meinhard Schilling
IFMBE Proceedings, Volume 25/II, 898–900 - 2009

Magnetic relaxation imaging of magnetic nanoparticle distributions
Dennis Rühmer, Erik Heim, Thilo Wawrzik, Frank Ludwig, Meinhard Schilling
IFMBE Proceedings, Volume 25/VII, 418–420 - sep 2009

The EMG has developed a hybrid system that combines tomographic imaging in magnetic particle imaging (MPI) with alternating magnetic field heating in order to achieve the targeted release of active pharmaceutical ingredients. Low-frequency magnetic fields are generated via coils for localised control. In order to realise a cost-efficient prototype, a commercial DC current source is to be extended to a bipolar source by means of a relay circuit, the control of which is realised via a microcontroller board with ModBus interface (or comparable).

Prior knowledge: C/C#, ESP32, bus protocols (recommended)

Keywords: microcontroller, electronics, programming

The first animal experiments with a Magnetic Particle Imaging (MPI) system built at EMG are to begin at Hannover Medical School (MHH) in 2025. The test animal (mouse) will be put under anaesthesia for imaging and will then be fixed in a simple 3D-printed holder ("mouse bed") in the imaging system. Ideally, at least one vital parameter (e.g. respiration, temperature, ECG, etc.) should be recorded. This topic is suitable for a Bachelor's or Master's thesis.

Prior knowledge: CAD, 3D printing, electronics

Keywords: electronics, CAD / 3D printing, small animal imaging

A magnetic inductor (= heating system) is to be constructed for the inductive heating of samples with magnetic nanoparticles. There is already a prototype based on ZVS technology (zero voltage switching) with very simple electronics. As part of this thesis, new electronics for (S)PWM-based control of the power signal with frequency and amplitude control are now to be realised. The inverter output stage will also be optimised for longer operating times.

Prior knowledge: Electronics / hobbyist, microcontroller, possibly ASIC

Keywords: microcontroller, electronics, programming

Magnetic tweezers are used for the contactless manipulation of magnetic particles using magnetic fields. An experimental prototype of a magnetic field system was set up in an earlier master's thesis. Now the particles are to be moved along defined paths in the microscope (PacMan in the labyrinth). For this purpose, the setup must be improved in some places and a corresponding control must be realised in software. The objective of the work is widely adaptable as a Bachelor's or Master's thesis.

Prior knowledge: None

Keywords: magnetic tweezers, microscopy, programming