Biological systems are extremely complex and constantly changing. The neurons in the human brain are the most complex and also the most sensitive to disturbances. Conventional measurement methods often fail to adequately capture these delicate processes or interfere with the cells themselves. This is precisely where the Ing4Life project comes in: It develops new, tiny measurement systems on a chip that make it possible to observe living nerve cells in real time under conditions as close to natural as possible — with high accuracy, efficiency, and reproducibility.
To achieve this, modern technologies from microelectronics, optics, and microfluidics are combined on chip systems; for example, new technologies are needed to enable the real-time analysis of multiple parameters in individual, undisturbed living cells. These technologies should be multiplex-capable to allow for the simultaneous analysis of many cells, and they should be suitable for mass production to minimize costs. Advances in the fields of microfluidics, microfabrication, and microelectromechanical systems (MEMS) are collectively referred to as “lab-on-a-chip.” On these chips, nerve cells can be continuously supplied with nutrients, specifically stimulated, and simultaneously monitored electrically and optically. Thanks to the high degree of miniaturization, disruption to the cells is minimized, allowing their natural function to be preserved.
A particular focus is on the brain, since nerve cells there not only transmit signals but also constantly adapt, network with one another, and interact with so-called glial cells. Disruptions to this delicate balance play a central role in age-related diseases. New insights into this could help us better understand the causes of dementia and develop targeted new medications.
Prof. Dr. Martin Korte
TU Braunschweig
Institut für Zell- und Neurobiologie (IZN)
Abt. Zelluläre Neurobiologie
Phone: +49 (0)531 391 3220
Email: m.korte@tu-braunschweig.de
Dr. Anita Remus
TU Braunschweig
FSP Engineering for Health - BRICS Geschäftsführung
Phone: +49(0)531 391 55102
Email: a.remus(at)tu-braunschweig.de