Publications

- 2022 -

• Kopenhagen, A. Ramming, I., Camp, B., Hammerschmidt, S., Fulde, M., Müsken, M., Steinert, M., and Bergmann^*, S. (2022) Streptococcus pneumoniae affects endothelial cell migration in microfluidic circulation. Special Section: Infectious Agents and Diseases. Frontiers in Microbiology. doi: 10.3389/fmicb.2022.852036 *) corresponding author

- 2020 -

• Steinert, M., Ramming, I., and Bergmann^*, S. (2020) Impact of Von Willebrand Factor on bacterial pathogenesis, Research Topic: Vascular Biology, Haemostasis and Extracellular Nucleic Acids in Vascular Diseases and Immunity. A Tribute to Klaus T. Preissner. Frontiers in Medicine, Hematology, Section, 31 (152). doi: 10.3791/60323. *) corresponding author

- 2019 -

• Jagau, H., Behrens, I.K., Steinert, M., and Bergmann^*, S. (2019b) Pneumococcus infection of primary human endothelial cells in constant flow, Journal of Visualized Experiments, 31 (152). doi: 10.3791/60323. *) corresponding author

• Jagau, H., Behrens, I.K., Lahme, K., Lorz G., Köster, R.W., Schneppenheim, R., Obser, T., Brehm, M.A., König, G., Kohler, T.P., Rohde, M., Frank, R., Tegge, W., Fulde, M., Hammerschmidt, S., Steinert, M., and Bergmann^*, S. (2019a) Von Willebrand factor mediates pneumococcal aggregation and adhesion in blood flow, Frontiers in Microbiology,  26 (10): 511. doi: 10.3389/fmicb.2019.00511. *) corresponding author
• Nerlich, A., Kohler, T.P., Eichhorn, I., Lapschies, A.-M., Krienke, P., Hammerschmidt, S., Bergmann, S., Rohde, M., Fulde, M. (2019) Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM, Virulence 10(1): 194-206. doi: 10.1080/21505594.2019.1589362.

- 2017 -

• Fulde, M., Bergmann*, S.  (2017) “Impact of Streptococcal Enolase in Virulence, Section 3: Protein Moonlighting in bacterial virulence” In: “Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections” Edt. Brian Henderson, Wiley Inc. Chapter 16, ISBN: 978-1-118-95111-8. *) corresponding author
• Bergmann, S., Eichhorn, I., Kohler, T.P., Hammerschmidt, S., Goldmann, O., Rohde, M., Fulde, M. (2017) SCM, the M protein of Streptococcus canis binds Immunoglobulin G. Frontiers in Cellular and Infection Microbiology, 28 (7): 80. doi: 10.3389/fcimb.2017.00080.

- 2016 -

• Beims, H., Overmann, A., Fulde, M., Steinert, M., and Bergmann*, S. (2016) Isolation of Staphylococcus sciuri from horse skin infection. Open Veterinary Journal, 6(3): 242-246. doi:10.4314/ovj.v6i3.14. *) corresponding author
• Zakrzewicz*, D., Bergmann*, S., Didiasova, M., Giaimo, B.D., Borggrefe, T., Mieth, M., Hocke, A. C., Lochnit, G., Preissner, K.T., Wygrecka M. (2016) Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells Scientific Reports, 28(6): 37758. doi: 10.1038/srep37758. *) shared first authorship
• Donner, J. Bunk, B., Schober, I., Spröer, C., Bergmann, S., Jarek, M., Overmann, J., Wagner-Döbler, I. (2016) Complete genomes of three multidrug-resistant clinical isolates of Streptococcus pneumoniae serotype 19A with different susceptibility to the myxobacterial metabolite Carolacton". Genome, 16;5(7): e01641-16. doi: 10.1128/genomeA.01641-16.
• Donner, J., Reck, M., Bergmann, S., Kirschning, A., Müller, R., and Wagner-Döbler, I. (2016) Carolacton is a bactericidal compound inhibiting growth of Streptococcus pneumoniae TIGR4 and drug resistant clinical isolates of serotype 19A. Scientific Reports, 11(6): 29677. doi: 10.1038/srep29677.

- 2015 -

• Münch, K.M., Müller, J., Bergmann, S., Heyber S., Wienecke, S., Biedendieck, R., Münch R., Jahn D. (2015) Polar fixation of plasmids during recombinant protein production in Bacillus megaterium results in population heterogeneity. Applied and Environmental Microbiology, 81(17): 5976-86. doi: 10.1128/AEM.00807-15.
• Bergmann, S., Steinert, M. (2015) From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology International Review of Cell & Molecular Biology (IRCMB), 319: 1-44. doi: 10.1016/bs.ircmb.2015.06.003.
• Bergmann S., Agarwal, V., Hammerschmidt S. (2015) "Exploitation of Host Signal Transduction Pathways Induced by Streptococcus pneumoniae" In: "Streptococcus pneumoniae", Eds.: J.S. Brown, S. Hammerschmidt and C. Orihuela; Elsevier, pp. 347-358, ISBN-978-0-12-410530-0

- 2014 -

• Fulde, M., Bernardo-García, N., Rohde, M., Nachtigall, N., Frank, R., Preissner, K.T., Klett, J., Morreale, A., Chhatwal, G.S., Hermoso, J.A., and Bergmann*, S. (2014) Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator. Thrombosis and Haemostasis, 111(3): 401-16. doi: 10.1160/TH13-05-0421.
  *) corresponding author
• Agarwal,V.,  Sroka, M., Fulde, M., Bergmann, S., Riesbeck, K., Blom, A.M. (2014) Binding of Streptococcus pneumoniae Endopeptidase O (PepO) to Complement Component C1q modulates the Complement Attack and promotes Host Cell Adherence, Journal of Biological Chemistry, 289(22): 15833-44. doi: 10.1074/jbc.M113.530212.
• Blom, A.M., Bergmann, S., Fulde, M., Riesbeck, K., Agarwal, V. (2014) Streptococcus pneumoniae phosphoglycerate kinase is a novel complement inhibitor affecting the membrane attack complex formation. Journal of Biological Chemistry, 289(47): 32499-511. doi: 10.1074/jbc.M114.610212.

- 2013 -

• Fulde, M., Rohde, M., Polok A., Preissner K.T., Chhatwal G.S., Bergmann S. (2013) Cooperative plasminogen recruitment to the surface of Streptococcus canis via M protein and enolase enhances bacterial survival. mBio. 12;4(2): e00629-12. doi: 10.1128/mBio.00629-12.
• Bergmann*, S., Schoenen H., Hammerschmidt S. (2013) The interaction between bacterial enolase and plasminogen promotes adherence of Streptococcus pneumoniae to epithelial and endothelial cells. International Journal of Medical Microbiology, 303(8): 452-62. doi: 10.1016/j.ijmm.2013.06.002. *) corresponding author
• Agarwal, V., Kuchipudi, A., Fulde, M., Riesbeck, K., Bergmann, S., Blom, A.M. (2013) Streptococcus pneumoniae endopeptidase O (PepO): A Multifunctional Plasminogen and Fibronectin Binding Protein, Facilitating Evasion of Innate Immunity and Invasion of Host Cells. Journal of Biological Chemistry. 288(10): 6849-63. doi: 10.1074/jbc.M112.405530.
• Rosendahl, A., Bergmann, S., Hammerschmidt, S.,Goldmann, O., Medina, E. (2013) Lung Dendritic Cells Facilitate Extrapulmonary Bacterial Dissemination during Pneumococcal Pneumonia, Frontiers in Cellular and Infection Microbiology, 3: 21. doi: 10.3389/fcimb.2013.00021.
• Fulde, M., Steinert, M., Bergmann*, S. (2013) Functional similarities of streptococcal plasminogen binding proteins in plasminogen interaction, Frontiers in Cellular and  Infection Microbiology, 3: 85. doi: 10.3389/fcimb.2013.00085. *) corresponding author

- 2012 -

• Fuchs, E., Untucht, C., Rohde, M., Steinert, M., and Bergmann*, S. (2012). Capsule contributes to transmigration of Streptococcus pneumoniae serotype 7F meningitis isolates through complex blood-brain-barrier models. Journal of Bacteriology and Parasitology 3(4): 1-8. *) corresponding author
• Lüttge, M., Fulde, M.,Talay S.R., Nerlich, A., Rohde, M., Preissner, K.T., Hammerschmidt, S., Steinert, M., Mitchell T.J., Chhatwal, G.S., and Bergmann*, S. (2012) Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells. Cellular Microbiology, 14(2): 210-25. doi: 10.1111/j.1462-5822.2011.01712.x. *) corresponding author
• Centanni, M.*, Bergmann*, S., Turoni, S., Hammerschmidt, S., Chhatwal G.S., Brigidi, P., Candela, M. (2012) TNF-alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. Applied and Environmental Microbiology, 78(7): 2465-9. doi: 10.1128/AEM.07883-11. *) shared first authorship
• Hitzmann, A., Bergmann, S., Rohde, M., Chhatwal, G.S., Fulde, M. (2012) Identification and Characterization of the Arginine Deiminase System of Streptococcus canis. Veterinary Microbiology, 162(1): 270-7. doi: 10.1016/j.vetmic.2012.08.004.
• Agarwal, V., Hammerschmidt, S., Malm, S., Bergmann, S., Riesbeck, K., Blom, A.M. (2012) Enolase of Streptococcus pneumoniae binds specifically human complement inhibitor C4b-binding protein and mediates pneumococcal complement evasion. Journal of Immunology, 189(7): 3575-84. doi:10.4049/jimmunol.1102934.

- 2011 -

• Fulde, M., Rohde, M., Hitzmann, A., Preissner, K.T., Nitsche-Schmitz, P.D., Nerlich A., Chhatwal, G.S., and Bergmann, S. (2011) SCM, a novel M-like protein from Streptococcus canis binds (Mini)-plasminogen with high affinity and facilitates bacterial transmigration. Biochemical Journal, 434(3): 523-35. doi: 10.1042/BJ20101121.
• Untucht, C., Rasch, J., Rohde, M., Bergmann, S., Steinert, M. (2011) An optimized in vitro blood-brain barrier model reveals bidirectional transmigration of African trypanosome strains. Microbiology, 157(10): 2933-41. doi: 10.1099/mic.0.049106-0.
• Candela, M., Turroni, S., Centanni, M., Fiori, J., Bergmann, S., Hammerschmidt, S., Brigidi, P. (2011) Relevance of the Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment. Applied Environmental Microbiology, 7(19): 7072-6. doi: 10.1128/AEM.00413-11.
• Bernardo-Garciá, N., Bartual, S.G., Fulde, M., Bergmann, S., Hermoso, J.A. (2011) Crystallization and preliminary X-ray diffraction of phosphoglycertae kinase from Streptococcus pneumoniae. Acta Crystallographica, Section F., Structural Biology and Crystallization Communications, (1)67: 1285-9. doi: 10.1107/S1744309111030922.

- 2010 -

• Jeet Kaur, S., Nerlich, A., Bergmann S., Rohde, M., Fulde, M., Zähner, D., Hanski, E., Zinkernagel, A., Nizet, V., Chhatwal, G.S., Talay, S.R. (2010) The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells. Journal of Biological Chemistry, 285(36): 27798-805. doi: 10.1074/jbc.M109.098053.
• Jensch, I., Bergmann, S., Fulde, M., Hammerschmidt, S. (2010) PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections. Molecular Microbiology, 77(1): 22-43. doi: 10.1111/j.1365-2958.2010.07189.x.
• Candela, M., Centanni, M., Fiori, J., Biagi, E., Turroni, S., Orrico, C., Bergmann, S., Hammerschmidt, S., Brigidi, P. (2010) DnaK from Bifidobacterium animalis subsp. lactis is a surface-exposed human plasminogen receptor upregulated in response to bile salts. Microbiology, 156: 1609-18. doi: 10.1099/mic.0.038307-0.

- 2009 -

• Bergmann, S., Lang, A., Rohde, M., Rennemeier, C., Grashoff C., Preissner, K.T., Hammerschmidt, S. (2009) Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. Journal of Cell Science, 122(2): 256-267. doi: 10.1242/jcs.035600.
• Candela, M., Biagi, E., Centanni, M., Turroni, S., Vici, M., Musiani, F., Vitali, B., Bergmann, S., Hammerschmidt, S., Brigidi, P. (2009) Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology, 155: 3294-303. doi: 10.1099/mic.0.028795-0.

- 2008 -

• Candela, M., Miccoli, G., Bergmann, S., Turroni, S., Vitali, B., Hammerschmidt, S., Brigidi, P. (2008) Plasminogen-dependent proteolytic activity in Bifidobacterium lactis. Microbiology, 154(8): 2457-62. doi: 10.1099/mic.0.2008/017095-0.

- 2007 -

• Knaust, A., Weber, M.V., Hammerschmidt, S., Bergmann, S., Frosch, M., Kurzai, O. (2007) Cytosolic proteins contribute to surface plasminogen recruitment of Neisseria monocytogenes. Journal of Bacteriology, 189(8): 3246-55. PMID: 17307854.
• Candela, M., Bergmann, S., Vici, M., Vitali, B., Turroni, S., Eikmanns, B.J., Hammerschmidt, S., Brigidi, P. (2007) Binding of human plasminogen to Bifidobacterium. Journal of Bacteriology, 189(16): 5929-36. PMID: 17557824.

• Bergmann, S., Hammerschmidt S. (2007) Fibrinolysis and host response in bacterial infections. Thrombosis and Haemostasis, 98(3): 512-20. PMID: 17849039.

- 2006 -

• Bergmann, S., Hammerschmidt, S. (2006) Versatility of pneumococcal surface proteins.  Microbiology, 152: 295-303. PMID: 16436417.

• Hammerschmidt, S., Paterson G.K., Bergmann S., Mitchell, T.J. (2006) Pathogenesis of Streptococcus pneumoniae infections: adaptive immunity, innate immunity, cell biology, virulence factors. In: Birkhäuser Advances in Infectious Diseases: Community acquired Pneumonia. N. Suttorp / R. Marre (eds), pp.139-181, Birkhäuser Verlag, Basel, Schweiz

• Kolberg, J., Bergmann, S., Aase, A., Herstad, T. K., Rødal, G., Frank, R., Rohde, M., Hammerschmidt, S. (2006) Streptococcus pneumoniae enolase is important for plasminogen binding despite low levels of enolase protein on the bacterial cell surface. Microbiology, 152: 1307-17. PMID: 16622048.

- 2005 -

• Bergmann, S., Rohde, M., Preissner, K.T., Hammerschmidt, S. (2005) The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigration. Thrombosis and Haemostasis, 94(2): 304-311. PMID: 16113819.
• Pracht, D., Elm, C., Gerber, J., Bergmann, S., Rohde, M., Seiler, M., Kim, K.-S., Jenkinson, H. F., Nau, R., Hammerschmidt, S. (2005) PavA of Streptococcus pneumoniae modulates adherence, invasion and meningeal inflammation. Infection and Immunity, 73(5): 2680-2689. PMID: 15845469.

- 2004 -

• Bergmann, S., Rohde, M., Hammerschmidt S. (2004) Glyceraldehyde-3-Phosphate Dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasmin(ogen)-binding protein. Infection and Immunity, 72(4): 2416-9. PMID: 15039372.
• Bergmann, S., Frank, R., Rohde, M., Chhatwal, G.S., Hammerschmidt, S. (2004) Characterization of plasmin(ogen) binding to Streptococcus pneumoniae. Indian Journal of Medical Microbiology, 119 (Suppl.) 29-32. PMID: 15232158.
• Elm, C., Braathen R., Bergmann, S., Frank, R., Vaerman, J.-P. Kaetzel, C.S., Chhatwal, G.S., Johansen, F-E., Hammerschmidt, S. (2004) Ectodomains 3 and 4 of human polymeric immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. Journal of Biological Chemistry, 279(8): 6296-304. PMID: 14660617.
• Schaumburg, J., Diekmann, O, Hagendorff, P., Bergmann, S., Rohde, M., Hammerschmidt, S., Jänsch, L., Wehland, J. and Kärst, U. (2004) The cell wall subproteome of Listeria monocytogenes. Proteomics, 4: 2991-3006. PMID: 15378750.
• Ehinger, S., Schubert, W.D., Bergmann, S., Hammerschmidt, S., Heinz, D.W. (2004) Crystal structure of plasmin(ogen)-binding a-enolase from Streptococcus pneumoniae: evaluation of plasmin(ogen)-binding sites. Journal of Molecular Biology, 343: 997-1005. PMID: 15476816.

- 2003 -

• Bergmann, S., Frank, R., Diekmann, O., Wild, D., Bracht, D., Hammerschmidt, S. (2003) Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha–enolase of Streptococcus pneumoniae. Molecular Microbiology, 49(2): 411-423. PMID: 12828639.
• Jolodar, A., Fischer, P., Bergmann, S., Büttner D.W., Hammerschmidt, S., Brattig, N.W. (2003) Molecular cloning of an a-enolase from the human filarial parasite Onchocerca volvulus that binds human plasminogen. Biochemical and Biophysical Acta, 1627(2-3): 111-20. PMID: 12818429.

- 2001 -

• Bergmann, S., Rohde, M., Chhatwal, G.S., Hammerschmidt, S. (2001) α-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Molecular Microbiology, 40(6): 1273-1287. PMID: 11442827.