Processing of conjugated nanoparticle hybrid systems for use in biomedical diagnostics
Contact person: Viktor Maurer
A measurement principle that has caught a lot of attention in recent years due to the extremely high analytical sensitivity is called surface-enhanced Raman spectroscopy (SERS). SERS is based on plasmonic surfaces such as gold nanoparticles and leads to Raman signals which are up to 1010-fold higher than in conventional Raman spectroscopy. In this project, several multifunctional nanoparticle systems are synthesized and used for diagnostic SERS-based ex-vivo and in-vitro applications.
Fig : (a) Antibody-functionalized iron oxide and gold nanoparticles for magnetic purification and subsequent detection of tau-protein, (b) SERS-active hybrid nanoparticle system consisting of gold-coated iron-platinum nanoparticles encapsulated in an organic carrier particle and used for a highly sensitive in-vitro diagnostic.
Objectives and tasks of the iPAT:
- Establishment of different hybrid nanoparticle systems with tailored properties for SERS-based diagnostics
- Characterization of the particle synthesis and functionalization as well as acquisition of the essential process parameters to ensure the important product properties
- Diagnostic and therapeutic ex-vivo/in-vitro applications of the hybrid nanoparticles
– Physikalisch-Technische Bundesanstalt
– Medizinische Hochschule Hannover