TU BRAUNSCHWEIG

RESEARCH AIMS

Most biopolymers like proteins, DNA, and RNA molecules function inside the cell, but are probed in vitro, under test tube conditions. We are interested in studying biomolecular structure, function and aggregation directly in cellular environments to yield new insight on their function in health and disease. Currently we focus on neurodegenerative diseases as well as bona/cartilage malformations and disordered hormone metabolisms based on impaired sulfation pathways.

Further information regarding our research can be found here.


OUR GROUP



FEATURED PUBLICATIONS

Featured Publication 1: Stability Effect of Quinary Interactions Reversed by Single Point Mutations

 

D. Gnutt, S. Timr, J. Ahlers, B. König, E. Manderfeld, M. Heyden, F. Sterpone, S. Ebbinghaus, J.Am.Chem.Soc., 2019

 

Featured Publication 2: A biosensor-based framework to measure latent proteostasis capacity

R.J. Wood, A.R. Ormsby, M. Radwan, D. Cox, A. Sharma, T. Vöpel, S. Ebbinghaus, M. Oliveberg, G.E. Reid, A. Dickson, D.M. Hatters*
Nature Communications, 287, 2018

 

Featured Publication 3: Inhibition of Huntingtin Exon.1 Aggregation by the Molecular Tweezer CLR01

T. Vöpel, K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klärner, T. Schrader, G. Bitan, E. E. Wanker,  S. Ebbinghaus*, E. Sanchez-Garcia*
J. Am. Chem. Soc., 139(16):5640–5643, 2017.

 

Featured Publication 4: RNA hairpin folding in the crowded cell

M. Gao, D. Gnutt, A. Orban, B. Appel, F. Righetti, R. Winter, F. Narberhaus, S. Müller, S. Ebbinghaus, Angew. Chem. Int. Ed., 55(9):3224-8, 2016.

 


CURRENT FUNDING

  


CONTACT

Prof. Dr. Simon Ebbinghaus

S.Ebbinghaus[at]tu-braunschweig.de

BRICS / Room 227


  last changed 19.03.2019
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