Most biopolymers like proteins, DNA, and RNA molecules function inside the cell, but are probed in vitro, under test tube conditions. We are interested in studying biomolecular structure, function and aggregation directly in cellular environments to yield new insight on their function in health and disease. Currently we focus on neurodegenerative diseases as well as bona/cartilage malformations and disordered hormone metabolisms based on impaired sulfation pathways.

Further information regarding our research can be found here.



Featured Publication 1: Stability Effect of Quinary Interactions Reversed by Single Point Mutations


D. Gnutt, S. Timr, J. Ahlers, B. König, E. Manderfeld, M. Heyden, F. Sterpone, S. Ebbinghaus, J.Am.Chem.Soc., 2019


Featured Publication 2: A biosensor-based framework to measure latent proteostasis capacity

R.J. Wood, A.R. Ormsby, M. Radwan, D. Cox, A. Sharma, T. Vöpel, S. Ebbinghaus, M. Oliveberg, G.E. Reid, A. Dickson, D.M. Hatters*
Nature Communications, 287, 2018


Featured Publication 3: Inhibition of Huntingtin Exon.1 Aggregation by the Molecular Tweezer CLR01

T. Vöpel, K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klärner, T. Schrader, G. Bitan, E. E. Wanker,  S. Ebbinghaus*, E. Sanchez-Garcia*
J. Am. Chem. Soc., 139(16):5640–5643, 2017.


Featured Publication 4: RNA hairpin folding in the crowded cell

M. Gao, D. Gnutt, A. Orban, B. Appel, F. Righetti, R. Winter, F. Narberhaus, S. Müller, S. Ebbinghaus, Angew. Chem. Int. Ed., 55(9):3224-8, 2016.





Prof. Dr. Simon Ebbinghaus


BRICS / Room 227

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