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Entwicklung eines mikrofluidischen Perfusionssystems zur Untersuchung der Pankreasinsel-Funktion

Schulze, T., Mattern, K., Früh, E., Hecht, L., Rustenbeck, I., Dietzel, A. A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets. Biomed. Microdevices 19, (2017).

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2017      2016      2013 - 2015

Aktuelle Publikationen:

Rehbein, M. C., Husmann, S., Lechner, C., Kunick, C. & Scholl, S. Fast and calibration free determination of first order reaction kinetics in API synthesis using in-situ ATR-FTIR. Eur. J. Pharm. Biopharm. 126, 95–100 (2018).

Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts – A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. 126, 108–114 (2018).

Füller, J., Kellner, T., Gaid, M., Beerhues, L. & Müller-Goymann, C. C. Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro. Eur. J. Pharm. Biopharm. 126, 115–122 (2018).

Gaid, M., Biedermann, E., Füller, J., Haas, P., Behrends, S., Krull, R., Scholl, S., Wittstock, U., Müller-Goymann, C. & Beerhues, L. Biotechnological production of hyperforin for pharmaceutical formulation. Eur. J. Pharm. Biopharm. 126, 10–26 (2018).

Gädke, J., Thies, J.-W., Kleinfeldt, L., Schulze, T., Biedendieck, R., Rustenbeck, I., Garnweitner, G., Krull, R. & Dietzel, A. Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics. Eur. J. Pharm. Biopharm. 126, 67–74 (2018).

Kahle, J. & Wätzig, H. Interlaced Size Exclusion Chromatography for faster protein analysis. Eur. J. Pharm. Biopharm. 126, 101–103 (2018).

Meise, M., Niggemann, M., Dunens, A., Schoenitz, M., Kuschnerow, J. C., Kunick, C. & Scholl, S. Early process development of API applied to poorly water-soluble TBID. Eur. J. Pharm. Biopharm. 126, 2–9 (2018).

Beiβner, N., Mattern, K., Dietzel, A. & Reichl, S. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 2 – Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. 126, 166–176 (2018).

Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. 126, 89–94 (2018).

Haas, P., Gaid, M., Zarinwall, A., Beerhues, L. & Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. 126, 104–107 (2018).

Lakowitz, A., Godard, T., Biedendieck, R. & Krull, R. Mini review: Recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives. Eur. J. Pharm. Biopharm. 126, 27–39 (2018).

Mattern, K., Beißner, N., Reichl, S. & Dietzel, A. DynaMiTES – A dynamic cell culture platform for in vitro drug testing PART 1 – Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. 126, 159–165 (2018).

Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. 126, 149–158 (2018).

Schenkendorf, R., Xie, X., Rehbein, M., Scholl, S. & Krewer, U. The impact of global sensitivities and design measures in model-based optimal experimental design. Processes 6, (2018).

Cabiscol, R., Finke, J. H. & Kwade, A. Calibration and interpretation of DEM parameters for simulations of cylindrical tablets with multi-sphere approach. Powder Technol. 327, 232–245 (2018).

Beinert, S., Fragnière, G., Schilde, C. & Kwade, A. Multiscale simulation of fine grinding and dispersing processes: Stressing probability, stressing energy and resultant breakage rate. Adv. Powder Technol. 29, 573–583 (2018).

Gelker, M., Müller-Goymann, C. C. & Viöl, W. Permeabilization of human stratum corneum and full-thickness skin samples by a direct dielectric barrier discharge. Clin. Plasma Med. 9, 34–40 (2018).

Beißner, N., Zorn-Kruppa, M. & Reichl, S. Parameter study of shipping conditions for the ready-to-use application of a 3D human hemicornea construct in drug absorption studies. Int. J. Pharm. 536, 377–387 (2018).

Melzig, S., Niedbalka, D., Schilde, C. & Kwade, A. Spray drying of amorphous ibuprofen nanoparticles for the production of granules with enhanced drug release. Colloids Surfaces A Physicochem. Eng. Asp. 536, 133–141 (2018).

Meine, R., Becker, W., Falke, H., Preu, L., Loaëc, N., Meijer, L. & Kunick, C. Indole-3-carbonitriles as DYRK1A inhibitors by fragment-based drug design. Molecules 23, (2018).

Kahle, J., Maul, K. J. & Wätzig, H. The next generation of capillary electrophoresis instruments: Performance of CE-SDS protein analysis. Electrophoresis 39, 311–325 (2018).

2017  Zum Seitenanfang


Mecklenfeld, A. & Raabe, G. Comparison of RESP and IPolQ-Mod Partial Charges for Solvation Free Energy Calculations of Various Solute/Solvent Pairs. J. Chem. Theory Comput. 13, 6266–6274 (2017).

Erfle, P., Riewe, J., Bunjes, H. & Dietzel, A. Optically monitored segmented flow for controlled ultra-fast mixing and nanoparticle precipitation. Microfluid. Nanofluidics 21, (2017).

Beißner, S., Thies, J.-W., Bechthold, C., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform. J. Sensors Sens. Syst. 6, 341–350 (2017).

Xie, X., Schenkendorf, R. & Krewer, U. Robust Design of Chemical Processes Based on a One-Shot Sparse Polynomial Chaos Expansion Concept. Comput. Aided Chem. Eng. 40, 613–618 (2017).

Schenkendorf, R., Xie, X. & Krewer, U. An Efficient Polynomial Chaos Expansion Strategy for Active Fault Identification of Chemical Processes. Comput. Aided Chem. Eng. 40, 1675–1680 (2017).

Göke, K., Lorenz, T., Repanas, A., Schneider, F., Steiner, D., Baumann, K., Bunjes, H., Dietzel, A., Finke, J. H., Glasmacher, B., Kwade, A. Novel strategies for the formulation and processing of poorly water-soluble drugs. Eur. J. Pharm. Biopharm. (2017).

Göke, K., Bunjes, H. Parameters influencing the course of passive drug loading into lipid nanoemulsions. Eur. J. Pharm. Biopharm. (2017).

Overbeck, A., Günther, S., Kampen, I. & Kwade, A. Compression Testing and Modeling of Spherical Cells – Comparison of Yeast and Algae. Chem. Eng. Technol. 40, (2017).

Thies, J.-W., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Microfluidic quartz-crystal-microbalance (QCM) sensors with specialized immunoassays for extended measurement range and improved reusability. Microelectron. Eng. 179, (2017).

Steiner, D., Finke, J. H., Kwade, A. Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness. Chemie-Ingenieur-Technik 89, (2017).

Schulze, T., Mattern, K., Früh, E., Hecht, L., Rustenbeck, I., Dietzel, A. A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets. Biomed. Microdevices 19, (2017).

Haas, P., Gaid, M., Zarinwall, A., Beerhues, L., Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. (2017).

Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., Kunick, C. Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages. Malaria J. (2017), 16, 192 (1-10).

Meine, R., Blech, M., Lindhof, J., Kunick, C., 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile. Molbank (2017), M941.

K. Mattern, N. Beissner, S. Reichl, A. Dietzel, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 1-  Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. (2017).

N. Beissner, K. Mattern, A. Dietzel, S. Reichl, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 2- Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. (2017). 

Gaid, M., Wucherpfennig, T., Scholl, S., Beerhues, L., Krull, R., Challenges for the cultivation of plant cells on the example of Hypericum perforatum and Taxus chinensis, in: A. Pavlov, T. Bley (Eds), Bioprocessing of plant in  vitro systems, Reference Series in Phytochemistry, Springer, (2017) 1-26.

Füller J., Kellner T., Gaid M., Beerhues L., Müller-Goymann C.C. Stabilization of hyperforin dicyclohexylammonium salt with dissolved albumin and albumin nanoparticles for studying hyperforin effects on 2D cultivation of keratinocytes in vitro.  Eur. J. Pharm. Biopharm. (2017).

Göke, K., Lorenz, T., Repanas, A., Schneider, F., Steiner, D., Baumann, K., Bunjes, H., Dietzel, A., Finke, J. H., Glasmacher, B., Kwade, A. Novel strategies for the formulation and processing of poorly water-soluble drugs. Eur. J. Pharm. Biopharm. (2017).

Göke, K., Bunjes, H. Parameters influencing the course of passive drug loading into lipid nanoemulsions. Eur. J. Pharm. Biopharm. (2017).

Overbeck, A., Günther, S., Kampen, I. & Kwade, A. Compression Testing and Modeling of Spherical Cells – Comparison of Yeast and Algae. Chem. Eng. Technol. 40, (2017).

Thies, J.-W., Kuhn, P., Thürmann, B., Dübel, S. & Dietzel, A. Microfluidic quartz-crystal-microbalance (QCM) sensors with specialized immunoassays for extended measurement range and improved reusability. Microelectron. Eng. 179, (2017).

Steiner, D., Finke, J. H., Kwade, A. Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness. Chemie-Ingenieur-Technik 89, (2017).

Schulze, T., Mattern, K., Früh, E., Hecht, L., Rustenbeck, I., Dietzel, A. A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets. Biomed. Microdevices 19, (2017).

Haas, P., Gaid, M., Zarinwall, A., Beerhues, L., Scholl, S. Downstream processing of hyperforin from Hypericum perforatum root cultures. Eur. J. Pharm. Biopharm. (2017).

Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., Kunick, C. Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages. Malaria J. (2017), 16, 192 (1-10).

Meine, R., Blech, M., Lindhof, J., Kunick, C., 7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile. Molbank (2017), M941.

K. Mattern, N. Beissner, S. Reichl, A. Dietzel, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 1-  Engineering of microfluidic system and technical simulations. Eur. J. Pharm. Biopharm. (2017).

N. Beissner, K. Mattern, A. Dietzel, S. Reichl, DynaMiTES - a dynamic cell culture platform for in vitro drug testing PART 2- Ocular DynaMiTES for drug absorption studies of the anterior eye. Eur. J. Pharm. Biopharm. (2017). 

Gaid, M., Wucherpfennig, T., Scholl, S., Beerhues, L., Krull, R., Challenges for the cultivation of plant cells on the example of Hypericum perforatum and Taxus chinensis, in: A. Pavlov, T. Bley (Eds), Bioprocessing of plant in vitro systems, Reference Series in Phytochemistry, Springer, (2017) 1-26.

Füller, J. & Müller-Goymann, C. C. Anti-proliferative and anti-migratory effects of hyperforin in 2D and 3D artificial constructs of human dermal fibroblasts - A new option for hypertrophic scar treatment? Eur. J. Pharm. Biopharm. (2017).

Gaid, M., Biedermann, E., Füller, J., Haas, P., Behrends, S., Krull, R., Scholl, S., Wittstock, U., Müller-Goymann, C. & Beerhues, L. Biotechnological production of hyperforin for pharmaceutical formulation. Eur. J. Pharm. Biopharm. (2017).

Schlütke, L., Immer, M., Preu, L., Totzke, F., Schächtele, C., Kubbutat, M. H. G. & Kunick, C. Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors. Eur. J. Pharm. Biopharm. (2017).

Gädke, J., Kleinfeldt, L., Schubert, C., Rohde, M., Biedendieck, R., Garnweitner, G. & Krull, R. In situ affinity purification of his-tagged protein A from Bacillus megaterium cultivation using recyclable superparamagnetic iron oxide nanoparticles. J. Biotechnol. 242, (2017).

Walisko, J., Vernen, F., Pommerehne, K., Richter, G., Terfehr, J., Kaden, D., Dähne, L., Holtmann, D. & Krull, R. Particle-based production of antibiotic rebeccamycin with Lechevalieria aerocolonigenes. Process Biochem. 53, (2017).

Lakowitz, A., Krull, R. & Biedendieck, R. Recombinant production of the antibody fragment D1.3 scFv with different Bacillus strains. Microb. Cell Fact. 16, (2017).

Mecklenfeld, A. & Raabe, G. Efficient solvation free energy simulations: impact of soft-core potential and a new adaptive λ-spacing method. Mol. Phys. (2017).


2016  Zum Seitenanfang


Göke K., Roese E., Arnold A., Kuntsche J., Bunjes H., Control over particle size distribution by autoclaving poloxamer-stabilized trimyristin nanodispersions, Mol. Pharmaceutics 13 (2016) 3187–3195.

Emenike, V. N. & Krewer, U. Model-Based Optimal Design of Continuous-Flow Reactors for the Synthesis of Active Pharmaceutical Ingredients. Chemie-Ingenieur-Technik 88, (2016).

Gehrmann S., Bunjes H., Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification, Chem. Eng. J. 284 (2016) 716–723.

Schenkendorf, R. Supporting the shift towards continuous pharmaceutical manufacturing by condition monitoring. in Conference on Control and Fault-Tolerant Systems, SysTol (2016).

Steiner, D., Finke, J. H., Breitung-Faes, S. & Kwade, A. Breakage, temperature dependency and contamination of Lactose during ball milling in ethanol. Adv. Powder Technol. 27, (2016).

Steiner, D., Finke, J. H. & Kwade, A. Instant ODFs - Development of an intermediate, nanoparticle-based product platform for individualized medication. Eur. J. Pharm. Biopharm. (2016).

Orban, O. C. F., Korn, R. S., Benítez, D., Medeiros, A., Preu, L., Loaëc, N., Meijer, L., Koch, O., Comini, M. A. & Kunick, C. 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms. Bioorganic Med. Chem. 24, (2016).

Dietzel, A. Microsystems for pharmatechnology: Manipulation of fluids, particles, droplets, and cells. (2016).

Andermark, V., Göke, K., Kokoschka, M., Abu El Maaty, M. A., Lum, C. T., Zou, T., Sun, R. W.-Y., Aguiló, E., Oehninger, L., Rodríguez, L., Bunjes, H., Wölfl, S., Che, C.-M. & Ott, I. Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex. J. Inorg. Biochem. 160, (2016).

Weidner, T., Nasereddin, A., Preu, L., Grünefeld, J., Dzikowski, R., Kunick, C. Novel 2-phenoxyanilide congeners derived from a hit structure of the TCAMS: Synthesis and evaluation of their in vitro activity against plasmodium falciparum. Molecules 21, (2016).

Gaid, M., Haas, P., Beuerle, T., Scholl, S. & Beerhues, L. Hyperforin production in Hypericum perforatum root cultures. J. Biotechnol. 222, (2016).

Dietzel, A. Preface. Microsystems Pharmatechnology Manip. Fluids, Part. Droplets, Cells (2016).

Schulze, T., Morsi, M., Brüning, D., Schumacher, K. & Rustenbeck, I. Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution. Endocrine 51, (2016).

El-Awaad, I., Bocola, M., Beuerle, T., Liu, B. & Beerhues, L. Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis. Nat. Commun. 7, (2016).

Eugen, K., Thies, J.-W. J.-W., Andreas, D., Koch, E., Thies, J.-W. J.-W. & Dietzel, A. Periodic convection of superparamagnetic beads within a microfluidic channel by interlocked, electroplated structures activated by a static field. Microelectron. Eng. 158, 46–51 (2016).

Dietzel, A. A brief introduction to microfluidics. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).

Beißner, N., Reichl, S. & Lorenz, T. Organ on chip. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).

Steiner, D., Finke, J. H. & Kwade, A. Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill. Int. J. Pharm. 511, (2016).

Schilde, C., Gothsch, T., Beinert, S. & Kwade, A. Microsystems for dispersing nanoparticles. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).

Bunjes, H. & Müller-Goymann, C. C. Microsystems for emulsification. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).

Eichler, M., Lachmann, K. & Klages, C.-P. Surface functionalization of microfluidic devices. Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells (2016).


2013-2015  Zum Seitenanfang


Joseph S., Rappolt M., Schoenitz M., Huzhalska V., Augustin W., Scholl S., Bunjes H., Stability of the metastable α-polymorph in solid triglyceride drug carrier nanoparticles, Langmuir 31 (2015) 6663–6674.

Fiesel, T., Gaid, M., Müller, A., Bartels, J., El-Awaad, I., Beuerle, T., Ernst, L., Behrends, S. & Beerhues, L. Molecular cloning and characterization of a xanthone prenyltransferase from hypericum calycinum cell cultures. Molecules 20, (2015).

Meine, R., Falke, H., Kötz, J., Schweda, S. I. & Kunick, C. 7-iodo-1H-indole-3-carbonitrile. Molbank 2015, (2015).

Joseph S., Bunjes H., Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions, Eur. J. Pharm. Biopharm. 87 (2014) 176–186.

Wilkins, M. R., Aldashev, A. A., Wharton, J., Rhodes, C. J., Vandrovcova, J., Kasperaviciute, D., Bhosle, S. G., Mueller, M., Geschka, S., Rison, S., Kojonazarov, B., Morrell, N. W., Neidhardt, I., Surmeli, N. B., Aitman, T. J., Stasch, J.-P., Behrends, S. & Marletta, M. A. α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among kyrgyz highlanders. Circ. Cardiovasc. Genet. 7, (2014).

Wöhl-Bruhn S., Bertz A., Kuntsche J., Menzel H., Bunjes H., Variations in polyethylene glycol brands and their influence on the preparation process of hydrogel microspheres, Eur. J. Pharm. Biopharm. 85 (2013) 1215–1218.

Kupetz E., Preu L., Kunick C., Bunjes H., Parenteral formulation of an antileishmanial drug candidate – Tackling poor solubility, chemical instability, and polymorphism, Eur. J. Pharm. Biopharm. 85 (2013) 511–520.

Ryczak, J., Papini, M., Lader, A., Nasereddin, A., Kopelyanskiy, D., Preu, L., Jaffe, C. L. & Kunick, C. 2-Arylpaullones are selective antitrypanosomal agents. Eur. J. Med. Chem. 64, (2013).


  aktualisiert am 29.05.2018
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