Cell Biology of Development and Function of the CNS - Course 2 (Bio-ZB 21)

Course content

In the course 2 “Cell Biology of Development and Function of the CNS”, the participants are supposed to work on the experiments using transgenic zebrafish as a model for neurodegenerative disease. The following content will be provided and discussed: 1) Neurodegenerative disease modeling by expression of disease causative genes. 2) Alterations of neuron specific gene expression affected in neurodegenerative disease models (in situ hybridization, RT-PCR etc.). 3) Controlling toxic gene expression and its activity by optogenetics. 4) In vivo imaging of degenerating neurons and glial activation in neurodegenerative disease models.