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Logo Zentrum für Pharmaverfahrenstechnik der TU Braunschweig
Dept. 2 - Pharmaceutical-chemical Process Technology
  • Structure
    • Dept. 1 - Pharmaceutical-biological Process Technology
    • Dept. 2 - Pharmaceutical-chemical Process Technology
    • Dept. 3 - Formulation and Packaging Technology
    • Dept. 4 - Microdevices and Analytics
    • CG 5 - Multi-scale Simulations of Pharmaceutical Processes
    • CG 6 - Pharmaceutical Manufacturing Engineering

Dept. 2 - Pharmaceutical-chemical Process Technology

TBID (4,5,6,7-Tetrabrom-2-1H-imidazol-2yl-isoindolin-1,3-dion)
TBID (4,5,6,7-Tetrabrom-2-1H-imidazol-2yl-isoindolin-1,3-dion)



Research activities are directed towards the realization of continuous manufacturing processes for synthetic API integrating reactant prepara­tion, synthesis and downstream processing. Specifically, manufacturing processes for protein kinase inhibitors and organometallic drugs are investigated. Processes are performed in integrated "milli-plants" with typical throughput of 100 to 500 g/h. Selection, design and operation of the individual process steps as well as the corres­ponding equipment are chosen such that they are representative for large scale processes and may thus serve as basis for scale-up to technical scale. Due to their low solubility in aqueous systems, synthesis and downstream processing of the API require a precise monitoring and control of temperature, concentration, residence time as well as energy management. For the latter, process intensification concepts comprise of ultrasound, micro wave or other techniques. Process synthesis is supported by high throughput experimental techniques combined with predictive methods for solvent selection and parameter optimiza­tion. Additionally theoretical approaches, based on the concept of Elementary Process Functions, are applied to identify alternative process paths. Special attention is dedicated towards integrated process concepts with recycling of solvent streams as well as treatment of side product or residual streams. Experimental data are complemented with process and equipment simulation to establish consistent mass, component and energy balances as well as characteristic performance assessment.

[Translate to English:] UHPLC für die Reinheitsbestimmung
[Translate to English:] Syntheseansatz eines Proteinkinaseinhibitors aus einem Parameter-Screening

left: UHPLC used for the determination of product purity; right: A batch of a protein kinase inhibitor synthesized during a parameter screening.


Heads of Department:

Prof. Dr.-Ing. Stephan Scholl | TU Braunschweig
Institute of Chemical and Thermal Process Engineering
Langer Kamp 7 | 38106 Braunschweig
E-Mail: s.scholl(at)tu-braunschweig.de | Phone: +49(0)531 391-2780

 

Prof. Dr. rer. nat. Ingo Ott | TU Braunschweig
Institute of Medical and Pharmaceutical Chemistry
Beethovenstraße 55 | 38106 Braunschweig
E-Mail: ingo.ott(at)tu-braunschweig.de | Phone: +49(0)531 391-2743

Institutes involved:

  • Institute of Chemical and Thermal Process Engineering

  • Institute of Medicinal and Pharmaceutical Chemistry

  • Institute of Separation and Process Technology TU Clausthal

  • Institute of Energy and Process Systems Engineering

  • Institut of Thermodynamics

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