Schrader, M., Schrinner, K., Polomsky, L., Ivanov, D., Kampen, I., Schilde, C., Krull, R., Kwade, A.
Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions
Frontiers in Bioengineering and Biotechnology Section Bioprocess Engineering 11 (2023), 12541361171055
https://doi.org/10.3389/fbioe.2023.12541361171055
Brune, S.E., Hoppenreijs, L.J.G., Kühl, T., Lautenbach, V., Walter, J., Peukert, W., Schwarz, K., Imhoff, D., Boom, R.M., Krull, R., Keppler, J.K., Biedendieck, R.
Precision fermentation as a route to modify β-lactoglobulin structure through substitution of specific cysteine residues
International Dairy Journal 147 (2023), 105772
https://doi.org/10.1016/j.idairyj.2023.105772
Heydorn, · R. L., Lammers, D., Gottschling, M., Dohnt, K.
Effect of food industry by‑products on bacterial cellulose production and its structural properties
Cellulose 30 (2023), 4159–4179
https://doi.org/10.1007/s10570-023-05097-9
Hoppenreijs L.J.G., Overbeck, A., Brune, S.E., Biedendieck, R., Krull, R., Kwade, A., Boom, R.M., Keppler, J.K.
Amyloid-like aggregation of recombinant β-lactoglobulin at pH 3.5 and 7.0: Is disulfide bond removal the key to fibrillation?
International Journal of Biological Macromolecules 224 (2023), 124855
https://doi.org/10.1016/j.ijbiomac.2023.124855
Hoppenreijs, L.J.G., Brune, S.E., Biedendieck, R., Krull, R., Boom, R.M., Keppler, J.K.
Fibrillation of β-lactoglobulin at pH 2.0: impact of cysteine substitution and disulfide bond reduction
Food Hydrocolloids 141 (2023), 108727
https://doi.org/10.1016/j.foodhyd.2023.108727
Dinius, A., Schrinner, K., Schrader, M., Kozanecka, Z.J., Brauns, H., Klose, L., Weiß, H., Kwade, A., Krull, R.
Morphology engineering for novel antibiotics - Glass microparticles and soy lecithin effect rebeccamycin production and cellular morphology of filamentous actinomycete Lentzea aerocolonigenes
Frontiers in Bioengineering and Biotechnology 11 (2023), 1171055
https://doi.org/10.3389/fbioe.2023.1171055
Dinius, A., Kozanecka, Z.J., Hoffmann, K.P., Krull, R.
Intensification of bioprocesses with filamentous microorganisms
Physical Sciences Reviews (2023)
https://doi/10.1515/psr-2022-0112
Laible, A.R., Dinius, A., Schrader, M., Krull, R., Kwade, A., Briesen, H., Schmideder, S.
Effects andinteractions of metal oxides in microparticle-enhanced cultivation of filamentous microorganisms
Engineering in Life Sciences 22 (2022), 725 – 743,
DOI: 10.1002/elsc.202100075
Heydorn, R.L., Niebusch, J., Lammers, D., Görke, M., Garnweitner, G., Dohnt, K., Krull, R.
Production and characterization of bacterial cellulose separators for Nickel-Zinc batteries
Energies 15 (2022), 5727,
DOI: 10.3390/en15155727
Viebrock, K., Rabl, D., Meinen, S., Wunder, P., Meyer, J.-A., Frey, L. J., Rasch, D., Dietzel, A., Mayr, T., Krull, R.
Microsensor in microbioreactors: Full bioprocess characterization in a novel capillary-wave microbioreactor
Biosensors 12 (2022), 512.
doi.org/10.3390/bios12070512
Kubannek, F., Block, J., Munirathinam, B., Krull, R.
Reaction kinetics of anodic biofilms under changing substrate concentrations: Uncovering shifts in Nernst-Monod curves via substrate pulses
Special Issue: Dedicated to Professor Thomas Scheper
Engineering in Life Sciences 22 (2022), 152 – 164,
https://doi/10.1002/elsc.202100088
Frey, L.J., Krull, R.
Microbioreactors for process development and cell-based screening studies
Advances in Biochemical Engineering/ Biotechnology 179 (2022), 67 – 100,
DOI: 10.1007/10_2020_130
Viebrock, K., Rabl, D., Meinen, S., Wunder, P., Meyer, J.-A., Frey, L. J., Rasch, D., Dietzel, A., Mayr, T., Krull, R.
Microsensor in microbioreactors: Full bioprocess characterization in a novel capillary-wave microbioreactor
Biosensors 12 (2022), 512.
doi.org/10.3390/bios12070512
Kubannek, F., Block, J., Munirathinam, B., Krull, R.
Reaction kinetics of anodic biofilms under changing substrate concentrations: Uncovering shifts in Nernst-Monod curves via substrate pulses
Engineering in Life Sciences 22 (2022), accepted
DOI: 10.1002/elsc.202000060
Meyer, V., Cairns, T., Barthel, L., King, R., P. Kunz, Schmideder, S., Müller, H., Briesen, H., Dinius, A., Krull, R.
Understanding and controlling filamentous growth of fungal cell factories: Novel tools and opportunities for targeted morphology engineering
Journal Fungal Biology and Biotechnology 8 (2021), 8,
DOI:10.1186/s40694-021-00115-6
Schrinner, K., Schrader, M., Niebusch, J., Althof, K., Schwarzer, F.A., Nowka, P.F., Dinius, A., Kwade, A., Krull, R.
Macroparticle-enhanced cultivation of Lentzea aerocolonigenes: Variation of mechanical stress and combination with lecithin supplementation for a significantly increased rebeccamycin production
Biotechnology and Bioengineering 118 (2021), 3984–3995
DOI: 10.1002/bit.27875
Keppler, J.K., Heyse, A., Scheidler, E., Uttinger, M.J., Fitzner, L., Jandt, U., Heyn, T.R., Lautenbach, V., Loch, J., Lohr, J., Kieserling, H., Günther, G., Kempf, E., Grosch, J.H., Lewiński, K., Jahn, D., Lübbert, C., Peukert, W., Kulozik, U., Drusch, S., Krull, R., Schwarz, K., Biedendieck, R.
Towards recombinantly produced milk proteins: Physicochemical and emulsifying properties of engineered whey protein beta-lactoglobulin variants
Food Hydrocolloids 110 (2021), 106132
DOI: 10.1016/j.foodhyd.2020.106132
Schrinner, K., Althof, K., Ebersbach, A., Grosch, J.H., Krull, R.
XAD resins for increased rebeccamycin productivity in cultivations of Lentzea aerocolonigenes
In occassion of Prof. Matthias Kraume 65th birthday
Chemie Ingenieur Technik 93 (2021), 282 – 288
DOI: 10.1002/cite.202000131
Böl, M., Schrinner, K., Tesche, S., Krull, R.
Challenges of influencing cellular morphology by morphology engineering techniques and mechanical induced stress on filamentous pellet systems — a critical review
Engineering in Life Sciences 21 (2021), 51 – 67
DOI: 10.1002/elsc.202000060
Frey, L.J., Vorländer, D., Ostsieker, H., Rasch, D., Lohse J.L., Breitfeld, M., Grosch, J.H., Wehinger, G.D., Bahnemann, J., Krull, R.
3D-printed micro bubble column reactor with integrated microsensors for biotechnological applications: From design to evaluation
Scientific Reports 11 (2021), 7276
DOI: 10.1038/s41598-021-86654-9
Bliatsiou, C., Schrinner, K., Waldherr, P., Tesche, S., Böhm, L., Kraume, M., Krull, R.
Rheological characteristics of filamentous cultivation broths and suitable model fluids
Biochemical Engineering Journal 163 (2020), 107746
DOI: 10.1016/j.bej.2020.107746
Jeannine C. Mayr, Luis F. M. Rosa, Natalia Klinger, Jan-Hendrik Grosch, Falk Harnisch, Antje C. Spiess
Response-Surface-Optimized and Scaled-Up Microbial Electrosynthesis of Chiral Alcohols
ChemSusChem
Frey, L.J., Vorländer, D., Rasch, D., Meinen, S., Müller, B., Mayr, T., Dietzel, A., Grosch, J.H., Krull, R.
Defining mass transfer in a capillary wave micro-bioreactor for dose-response and other cell-based assays
Biochemical Engineering Journal 161 (2020), 107667
DOI: 10.1016/j.bej.2020.107667
Engel CEA, Vorländer D, Biedendieck R, Krull R, Dohnt K (2020)
Quantification of microaerobic growth of Geobacter sulfurreducens
PLoS ONE 15 (2020) 1, e0215341, DOI: 10.1371/journal.pone.0215341
Godard T, Zuehlke D, Richter G, Wall M, Rohde M, Riedel K, Poblete-Castro I, Krull R, Biedendieck R (2020)
Metabolic rearrangements causing elevated proline and polyhydroxybutyrate accumulation during the osmotic adaptation response of Bacillus megaterium
Frontiers in Bioengineering and Biotechnology 8 (2020), 47 , DOI: 10.3389/fbioe.2020.00047
Heydorn RL, Engel CEA, Krull R, Dohnt K (2020)
Strategies for the targeted improvement of anodic electron transfer in micorbial fuel cells
ChemBioEng Reviews 7 (2019), 4 – 17, DOI: 10.1002/cite.201800214
Schrinner, K., Veiter, L., Schmideder, S., Doppler, P., Schrader, M., Münch, N., Althof, K., Kwade, A., Briesen, H., Herwig, C., Krull, R.
Morphological and physiological characterization of filamentous Lentzea aerocolonigenes: Comparison of biopellets by microscopy and flow cytometry
PLoS ONE, 15 (2020) 6, e0234125, DOI: 10.1371/journal.pone.0234125
Tesche S, Rösemeier-Scheumann R, Lohr J, Hanke R, Büchs J, Krull R (2019)
Salt-enhanced cultivation as morphology engineering tool for filamentous actinomycetes: Increased production of labyrinthopeptin A1 in Actinomadura namibiensis
Engineering in Life Sciences 19 (2019), 781–794, DOI: 10.1002/elsc.201900036
Eisenkolb I, Jensch A, Eisenkolb K, Kramer A, Buchholz PCF, Pleiss J, Spiess AC, Radde N (2019)
Kinetic modeling of biocatalytic reactions: A workflow for model calibration, selection and validation using Bayesian statistics
American Institute of Chemical Engineers. Accepted.
Kleinfeldt L, Gädke J, Biedendieck R, Krull R, Garnweitner G (2019)
Spray-dried hierarchical aggregates of iron oxide nanoparticles and their functionalization for biotechnological applications
American Chemical Society Omega 4 (2019), 16300−16308, DOI: 10.1021/acsomega.9b01549
Jmel MA, Anders N, Messaoud GB, Merzouki MN, Spiess AC, Smaali I (2019)
The stranded macroalga Ulva lactuca as a new alternative source of cellulose: Extraction, physicochemical and rheological characterization
Journal of Cleaner Production. 234:1421-1427
Al-Halhouli A, Albagdady A, Al-Faqheri W, Kottmeier J, Meinen S, Frey LJ, Krull R, Dietzel A (2019)
Enhanced inertial focusing of microparticles and cells by integrating trapezoidal microchambers in spiral microfluidic channels
RSC Advances 9 (2019), 19197 – 19204, DOI: 10.1039/c9ra03587g
Ohs R, Fischer K, Schoepping M, Spiess AC (2019)
Derivation and identification of a mechanistic model for a branched enzyme-catalyzed carboligation
Biotechnology Progress. Accepted.
Gaid M, Grosch JH, Möller S, Beerhues L, Krull R (2019)
Towards enhanced Hyperforin production in St. Johns wort root cultures
Engineering Life Sciences 19 (2019), 916 – 930, DOI: 10.1002/elsc.201900043
Dittmann J, Tesche S, Krull R, Böl M (2019)
The influence of salt-enhanced cultivation on the micromechanical behaviour of filamentous pellets
Biochemical Engineering Journal. 148, 65-76, DOI: 10.1016/j.bej.2019.04.023
Meinen S, Frey L, Krull R, Dietzel A (2019)
Resonant Mixing in Glass Bowl Microbioreactor Investigated by Microparticle Image Velocimetry
Micromachines 10(284), DOI:10.3390/mi10050284
Frey L, Vorländer D, Rasch D, Ostsieker H, Müller B, Schulze M, Schenkendorf R, Mayr T, Grosch JH, Krull R (2019)
Novel electrodynamic oscillation technique enables enhanced mass transfer and mixing for cultivation in micro-bioreactor
Biotechnology Progress 35 (2019), 5, e2827, DOI: 10.1016/j.bej.2019.04.023
Heydorn RL, Engel C, Krull R, Dohnt K (2019)
Strategien zur gezielten Verbesserung des anodenseitigen Elektronentransfers in mikrobiellen Brennstoffzellen
Chemie Ingenieur Technik. Chemie Ingenieur Technik 91, 744-757. DOI: 10.1002/cite.201800214
Schrader M, Pommerehne K, Wolf S, Finke B, Schilde C, Kampen I, Lichtenegger T, Krull R, Kwade A (2019)
Design of a CFD-DEM-based method for mechanical stress calculation and its application to glass bead-enhanced cultivations of filamentous Lentzea aerocolonigenes
Biochemical Engineering Journal. 148,116-130. DOI: 10.1016/j.bej.2019.04.014
Kluge S, Bonhage B, Viell J, Granström M, Kindler A, Spiess AC (2019)
Enzymatic production of cello-oligomers with endoglucanases
Cellulose. Accepted. DOI: 10.1007/s10570-019-02390-4
Pommerehne K, Walisko J, Ebersbach A, Krull R (2019)
The antitumor antibiotic rebeccamycin - Challenges and advanced approaches in production processes
Applied Microbiology and Biotechnology. 103, 3627–3636, DOI: 10.1007/s00253-019-09741-y
Engel C, Schattenberg F, Dohnt K, Schröder U, Müller S, Krull R (2019)
Long-term behavior of defined mixed cultures of Geobacter sulfurreducens and Shewanella oneidensis in bioelectrochemical systems
Frontiers in Bioengineering and Biotechnology. Frontiers in Bioengineering and Biotechnology - Bioenergy and Biofuels. 7,60. DOI: 10.3389/fbioe.2019.00060
Llado-Maldonado S, Krull J, Rasch D, Panjan P, Sesay A, Marques M, Szita N, Krull R (2019)
Application of a multiphase microreactor chemostat for the determination of reaction kinetics of Staphylococcus carnosus
Bioprocess and Biosystems Engineering. 42,953-961. DOI: 10.1007/s00449-019-02095-9
Mayr J, Grosch J-H, Hartmann L, Rosa LFM, Spiess AC, Harnisch F (2019)
Resting Escherichia coli as Chassis for Microbial Electrosynthesis: Production of Chiral Alcohols
ChemSusChem. 12(8):1631-1634. DOI: 10.1002/cssc.201900413
Lladó Maldonado S, Panjan P, Sun S, Rasch D, Sesay A, Mayr T, Krull R (2019)
A fully, online sensor-equipped, disposable multiphase microbioreactor as a screening platform for biotechnological applications
Biotechnology and Bioengineering. 116, 65–75. DOI: 10.1002/bit.26831
Di Marino D, Jestel T, Marks C, Viell J, Blindert M, Kriescher SMA, Spiess AC, Wessling M (2018)
Carboxylic acids production via electrochemical depolymerization of lignin
ChemElectroChem. Accepted. DOI: 10.1002/celc.201801676
Emenike VN, Xie X, Schenkendorf R, Spiess AC, Krewer U (2018)
Robust dynamic optimization of enzyme-catalyzed carboligation: A point estimate-based back-off approach
Computers and Chemical Engineering. 121:232-247. DOI: 10.1016/j.compchemeng.2018.10.006
Jestel T, Roth S, Heesel D, Kress A, Fischer A, Spiess AC (2018)
Laccase-induced HBT-grafting to milled beech wood reduces unspecific protein adsorption
Biocatalysis and Biotransformation. Accepted
Bednarz A, Jupke A, Spiess AC, Pfennig A (2018)
Aerated extraction columns for in-situ separation of bio-based diamines from cell suspensions
Journal of Chemical Technology and Biotechnology. 94:426-434. DOI:10.1002/jctb.5786
Lladó Maldonado S, Rasch D, Kasjanow A, Bouwes D, Krühne U, Krull R (2018)
Multiphase microreactors with intensification of oxygen mass transfer rate and mixing performance for bioprocess development
Biochemical Engineering Journal. 139: 57 – 67. DOI: 10.1016/j.bej.2018.07.023
Buchholz PCF, Ohs R, Spiess AC, Pleiss J (2018)
Progress Curve Analysis Within BioCatNet: Comparing Kinetic Models for Enzyme-Catalyzed Self-Ligation
Biotechnology Journal. Accepted. DOI: 10.1002/biot.201800183
Ohs R, Leipnitz M, Schoepping M, Spiess AC (2018)
Simultaneous identification of reaction and inactivation kinetics of an enzyme-catalyzed carboligation
Biotechnology Progress. 34(5):1081-1092. DOI: 10.1002/btpr.2656
Xie X, Ohs R, Spiess AC, Krewer U, Schenkendorf R (2018)
Moment-independent sensitivity analysis of enzyme-catalyzed reactions with correlated model parameters
IFAC-PapersOnLine. 51(2):753-758. DOI: 10.1016/j.ifacol.2018.04.004
Gaid M, Biedermann E, Füller J, Haas P, Behrends S, Krull R, Scholl S, Wittstock U, Müller-Goymann C, Beerhues L (2018)
Biotechnological production of hyperforin for pharmaceutical formulation
European Journal of Pharmaceutics and Biopharmaceutics. 126 (2018), 10 – 26 DOI: 10.1016/j.ejpb.2017.03.024
Lakowitz A, Godard T, Biedendieck R, Krull R (2018)
Recombinant production of tailored bio-pharmaceuticals in different Bacillus strains and future perspectives
European Journal of Pharmaceutics and Biopharmaceutics, 126: 27 – 39. DOI: 10.1016/j.ejpb.2017.06.008
Gädke J, Thies JW, Kleinfeldt L, Schulz T, Biedendieck R, Rustenbeck I, Garnweitner G, Krull R, Dietzel A (2018)
Selective manipulation of superparamagnetic nanoparticles for product purification and microfluidic diagnostics
European Journal of Pharmaceutics and Biopharmaceutics. 126: 67 – 74. DOI: 10.1016/j.ejpb.2017.09.008
Cürten C, Anders N, Juchem N, Ihling N, Volkenborn K, Knapp A, Jaeger KE, Büchs J, Spiess AC (2018)
Fast automated online xylanase activity assay using HPAEC-PAD
Analytical and Bioanalytical Chemistry. 410:57-69. DOI: 10.1007/s00216-017-0712-0
Jmel MA, Anders N, Yahmed NB, Schmitz C, Marzouki MN, Spiess A, Smaali I (2017)
Variations in Physicochemical Properties and Bioconversion Efficiency of Ulva lactuca Polysaccharides After Different Biomass Pretreatment Techniques
Applied Biochemistry and Biotechnology. In press. DOI: 10.1007/s12010-017-2588-z
Wang Y, Anders N, Spiess AC (2017)
Cellulase adsorption during the hydrolysis of organosolv- and organocat-pretreated beech wood
Energy & Fuels. In press. DOI: 10.1021/acs.energyfuels.7b01454
Gädke J, Thies JW, Kleinfeldt L, Kalinin A, Starke G, Lakowitz A, Biedendieck R, Garnweitner G, Dietzel A, Krull R (2017)
Integrated in situ-purification of recombinant proteins from Bacillus megaterium cultivation of using SPION in stirred tank bioreactors
Biochemical Engineering Journal, 126: 58–67, DOI: 10.1016/j.bej.2017.07.001
Bednarz A, Scherübel P, Spiess AC, Pfennig A (2017)
Optimization of settling behavior for an efficient solvent-extraction process for bio-based components
Chemical Engineering & Technology. In print. DOI: 10.1002/ceat.201700020
Ohs R, Wendlandt J, Spiess AC (2017)
How graphical analysis helps interpreting optimal experimental designs for nonlinear enzyme kinetic models
AIChE Journal. In press. DOI: 10.1002/aic.15814
Anders N, Schelden M, Roth S, Spiess AC (2017)
Automated chromatographic laccase-mediator-system activity assay
Analytical and Bioanalytical Chemistry. 409(20):4801-4809. DOI: 10.1007/s00216-017-0423-6
Walisko J, Vernen F, Pommerehne K, Richter G, Terfehr J, Kaden D, Dähne L, Holtmann D, Krull R (2017)
Particle-based production of antibiotic rebeccamycin with Lechevalieria aerocolonigenes
Bioprocess Biochemistry. 53:1-9. DOI: 10.1016/j.procbio.2016.11.017
Lakowitz A, Krull R, Biedendieck R (2017)
Recombinant production of the antibody fragment D1.3 scFv with different Bacillus strains
Microbial Cell Factories. 16:14. DOI: 10.1186/s12934-017-0625-9
Gädke J, Kleinfeldt L, Schubert C, Rohde M, Biedendieck R, Garnweitner G, Krull R (2017)
In situ affinity purification of his-tagged protein A from Bacillus megaterium cultivation using recyclable superparamagnetic iron oxide nanoparticles
Journal of Biotechnology. 242:55-63. DOI:10.1016/j.jbiotec.2016.11.018
Grosch JH, Wagner D, Knaup N, Keil T, Spiess AC (2016)
Influence of the Experimental Setup on the Determination of Enzyme Kinetic Parameters
Biotechnology Progress. Epub ahead of print. DOI: 10.1002/btpr.2390
Buchholz PCF, Vogel C, Reusch W, Pohl M, Rother D, Spiess AC, Pleiss J (2016)
BioCatNet: A Database System for the Integration of Enzyme Sequences and Biocatalytic Experiments
Chembiochem. Epub ahead of print. DOI: 10.1002/cbic.201600462
Begemann J, Ohs RBH, Ogolong AB, Eberhard W, Ansorger-Schumacher MB, Spiess AC (2016)
Model-based analysis of a reactor and control concept for oxidoreductions based on exhaust CO2-measurement
Process Biochemistry. 51:1397-1405. DOI: 10.1016/j.procbio.2016.06.024
Grosch J-H, Wagner D, Nistelkas V, Spiess AC (2016)
Thermodynamic activity-based intrinsic enzyme kinetic sheds light on enzyme-solvent interactions
Biotechnology Progress. Epub ahead of print. DOI: 10.1002/btpr.2401
Grosch J-H, Sieben M, Lattermann C, Kauffmann K, Büchs J, Spiess A (2016)
Enzyme activity deviates due to spatial and temporal temperature profiles in commercial microtiter plate readers
Biotechnology Journal. 4:519-29. DOI: 10.1002/biot.201500422
Krull R, Peterat G (2016)
Analysis of reaction kinetics during chemostat cultivation of Saccharomyces cerevisiae using a multiphase microreactor.
Biochem Eng J. 105:220-229. DOI: 10.1016/j.bej.2015.08.013
Gaid M, Wucherpfennig T, Scholl S, Beerhues L, Krull R (2016)
Challenges for the cultivation of plant cell and tissue cultures using the examples of Hypericum perforatum and Taxus chinensis
In: Series in Phytochemistry (Merillon, J. M., Ramawat, K. G. (eds.), Bioprocessing of Plant in vitro Systems (Pavlov, A. I., Bley, Th. (vol. eds.)), Springer
Krull R, Mönch-Tegeder J, Blotenberg J, Walisko R (2016)
Beeinflussung der Morphologie beanspruchungssensitiver, filamentöser Mikroorganismen
18. Köthener Rührer-Kolloquium, Hochschule Anhalt (FH), Vortragssammlung, 3 – 19, ISBN: 978-3-96057-010-3 , Köthen, 2016
Krull R, Lladó Maldonado S, Lorenz T, Demming S, Büttgenbach S (2016)
Microbioreactors.
In: Microsystems for Pharmatechnology. Manipulation of fluids, particles, droplets, and cells. Dietzel, A. (ed.)), Chapter 4, 99 – 152, Series Microsystems and Nanosystems, Springer Verlag, Berlin Heidelberg 2016
Peterat G, Lladó Maldonado S, Edlich A, Rasch D, Dietzel A, Krull R (2015)
Bioreaktionstechnik in mikrofluidischen Reaktoren.
Chem-Ing.-Tech. 87:505-517. DOI: 10.1002/cite.201400176
Hoennscheidt C, Margaritis A, Krull R (2015)
Novel applications of ubiquinone biopolymer nanocarriers for preventive and regenerative therapeutics: the Saccharomyces cerevisiae paradigm.
Int J Pharm. 478:416-425. DOI: 10.1016/j.ijpharm.2014.11.034
Pretor S, Bartels J, Lorenz T, Dahl K, Finke J H, Peterat G, Krull R, Al-Halhouli A T, Dietzel A, Büttgenbach S, Behrends S, Reichl S, Müller-Goymann C C (2015)
Cellular uptake of coumarin-6 under microfluidic conditions into HCE-T cells from nanoscale formulations.
Mol Pharm. 12:34-45. DOI: 10.1021/mp500401t
Walisko R, Moench-Tegeder J, Blotenberg J, Wucherpfennig T, Krull R (2015)
The taming of the shrew – controlling the morphology of filamentous eukaryotic and prokaryotic microorganisms.
In: Filaments in Bioprocesses, Series: Advances in Biochemical Engineering/ Biotechnology, Vol. 149, Scheper, T. (Series Ed.), Krull, R., Bley, T. (Vol. Eds.), Springer International Publishing Switzerland 2015.
Masthoff I, Gädke J, Krull R, Biedendieck R, Garnweitner G (2014)
Funktionalisierte Nanopartikel - Biokompatible Eisenoxid-Nanopartikel zur in situ-Magnetseparation von Bioprodukten.
CIT plus 10:46-48.
Adler P, Frey LJ, Berger A, Bolten C J, Hansen C E, Wittmann C (2014)
The key to acetate: Metabolic fluxes of acetic acid bacteria under cocoa pulp fermentation simulating conditions.
Appl Environ Microbiol. In press. DOI: 10.1128/AEM.01048-14
Peterat G, Schmolke H, Lorenz T, Llobera A, Rasch D, Al-Halhouli A T, Dietzel A, Büttgenbach S, Klages C-P, Krull R (2014)
Characterization of oxygen transfer in vertical micro bubble columns for aerobic biotechnological screening processes.
Biotechnol. Bioeng. 111:1809-1819. DOI: 10.1002/bit.25243
Kreyenschulte D, Krull R, Margaritis A (2014)
Recent advances in microbial biopolymer production and purification.
Crit. Rev. Biotechnol. 34(1):1-15. DOI: 10.3109/07388551.2012.743501
Wucherpfennig T, Schulz A, Pimentel A, Corkidi G,Sieblitz D, Pump M, Gorr G, Schütte K, Wittmann C, Krull R (2014)
Viability characterization of Taxus chinensis plant cell suspension cultures by rapid colorimetric- and image analysis-based techniques.
Bioproc. Biosyst. 37:1799-1808. DOI: 10.1007/s00449-014-1153-1
Berger A, Dohnt K, Tielen P, Jahn D, Becker J, Wittmann C (2014)
Robustness and Plasticity of Metabolic Pathway Flux among Uropathogenic Isolates of Pseudomonas aeruginosa.
PLoS ONE. 9(4):e88368. DOI: 10.1371/journal.pone.0088368
Etschmann MMW, Huth I, Walisko R, Schuster J, Krull R, Wittmann C, Schrader J (2014)
Improving 2-phenylethanol and 6-pentyl-alpha-pyrone production with fungi by microparticle enhanced cultivation (MPEC).
Yeast. 32:145-157. DOI: 10.1002/yea.3022
Hellriegel J, Günther S, Kampen I, Bolea-Albero A, Kwade A, Böl M, Krull R (2014)
A biomimetic gellan-based hydrogel as a physicochemical biofilm model.
J Biomater Nanobiotechnol. 5:83-97. DOI: 10.4236/jbnb.2014.52011
Tielen P, Rosin N, Meyer A-K, Dohnt K, Haddad I, Jänsch L, Klein J, Narten M, Pommerenke C, Scheer M, Schobert M, Schomburg D, Thielen B, Jahn D (2013)
Regulatory and Metabolic Networks for the Adaptation of Pseudomonas aeruginosa Biofilms to Urinary Tract-Like Conditions.
PLoS ONE 8:e71845.
van Duuren JB, Puchałka J, Mars AE, Bücker R, Eggink G, Wittmann C, Dos Santos VA (2013)
Reconciling in vivo and in silico key biological parameters of Pseudomonas putida KT2440 during growth on glucose under carbon-limited condition.
BMC Biotechnol. 13(1):93.
Rodrigues A, Trachtmann N, Becker J, Blotenberg J, Lohanatha A, Bolten C, Korneli C, de Souza Lima A, Porto L, Sprenger G, Wittmann C (2013)
Systems metabolic engineering of Escherichia coli for production of the antitumor drugs violacein and deoxyviolacein.
Metab. Eng. 20:29-41.
Hellmers F, Ferguson P, Koropatnick J, Krull R, Margaritis A (2013)
Characterization and in vitro cytotoxicity of doxorubicin-loaded γ-polyglutamic acid-chitosan composite nanoparticles
Biochemical Engineering Journal 75: 72-78, DOI: 10.1016/j.bej.2013.03.019
Hönnscheidt C, Kreyenschulte D, Margaritis A, Krull R (2013)
Production and characterization of stable quinine nano-dispersions using esterified γ-polyglutamic acid biopolymer.
Biochem. Eng. J. 79:259-266.
Ebert M, Laaß S, Burghartz M, Petersen J, Koßmehl S,Wöhlbrand L,Rabus R, Wittmann C, Tielen P, Jahn D (2013)
Transposon mutagenesis identified chromosomal and plasmid encoded genes essential for the adaptation of the marine bacterium Dinoroseobacter shibae to anaerobic conditions.
J. Bacteriol. in press.
Adler P, Bolten CJ, Dohnt K, Hansen CE, Wittmann C (2013)
Core fluxome and meta fluxome of lactic acid bacteria under cocoa pulp fermentation simulating conditions.
Appl Environ Microb. 79(18):5670-5681.
Kim JY, Wittmann C, Park JB (2013)
Production of non-proteinogenic amino acids from α-keto acid precursors with recombinant Corynebacterium glutamicum.
Biotechnol. Bioeng. In press
Becker J, Reinefeld J, Stellmacher R, Schäfer R, Lange A, Meyer H, Lalk M, Zelder O, von Abendroth G, Schröder H, Häfner S, Wittmann C (2013)
Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinic acid producing Basfia succiniciproducens.
Biotechnol. Bioeng. In press.
Bergmann S, David F, Clark W, Wittmann C, Krull R (2013)
Membrane fluidity of halophilic ectoine secreting bacteria related to osmotic and thermal treatment.
Bioproc. Biosyst. Eng. 36:1829-1841.
Schiefelbein S, Froehlich A, John GT, Beutler F, Wittmann C, Becker J (2013)
Oxygen supply in disposable shake flasks - prediction of oxygen transfer rate, oxygen saturation and maximum cell concentration during aerobic growth.
Biotechnol. Lett. In press.
Hellmers F, Ferguson P, Koropatnick J, Krull R, Margaritis A (2013)
Characterization and in vitro cytotoxicity of doxorubicin-loaded gamma-polyglutamic acid-chitosan composite nanoparticles.
Biochem. Eng. 75:72-78.
Buschke N, Becker J, Schäfer R, Kiefer P, Biedendieck R, Wittmann C (2013)
Systems metabolic engineering of xylose utilizing Corynebacterium glutamicum for production of 1,5-diaminopentane.
Biotechnol. J. In press.
Bergmann S, David F, Franco-Lara E, Wittmann C, Krull R (2013)
Ectoine production by Alkalibacillus haloalkaliphilus – bioprocess development using response surface methodology and model-driven strategies.
Eng. Life Sci. 13:399-407.
Buschke, N, Schäfer R, Becker J, Wittmann C (2013)
Metabolic engineering of industrial platform microorganisms for biorefinery applications - optimization of substrate spectrum and process robustness by rational and evolutive strategies.
Biores. Technol. 135:544-554.
Korneli C, Biedendieck R, David F, Jahn D, Wittmann C (2013)
High yield production of extracellular recombinant levansucrase by Bacillus megaterium.
Appl. Microbiol. Biotechnol. In press.
Böl M, Ehret A E, Bolea-Albero A, Hellriegel J, Krull R (2013)
Recent advances in mechanical characterisation of biofilm and their significance for material modelling.
CRC Cr. Rev. Biotechn. 33:145-171.
Poblete-Castro I, Binger D, Rodrigues A L, Becker J, Dos Santos V, Wittmann C (2013)
In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates.
Met. Eng. 15:113-123.
Kind S, Becker J, Wittmann C (2013)
Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway - metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum.
Metab. Eng. 15:184-195.
Korneli C, David F, Biedendieck R, Jahn D, Wittmann C (2013)
Getting the big beast to work - systems biotechnology of Bacillus megaterium for novel high-value proteins.
J. Biotechnol. 163:87-96.
Krull R, Wucherpfennig T, Eslahpazir Esfandabadi M, Walisko R, Melzer G, Hempel D C, Kampen I, Kwade A, Wittmann C (2013)
Characterization and control of fungal morphology for improved production performance in biotechnology.
J. Biotechnol. 163:112-123.
Wucherpfennig T, Lakowitz A, Krull R (2013)
Comprehension of viscous morphology - Evaluation of fractal and conventional parameters for rheological characterization of Aspergillus niger culture broth.
J. Biotechnol. 163:124-132.
Meza E, Becker J, Bolivar F, Guillermo G, Wittmann C (2012)
Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli.
Microb. Cell Fact. 11:127.
Demming S, Peterat G, Llobera A, Schmolke H, Bruns A, Kohlstedt M, Al-Halhouli A, Klages C-P, Krull R, Büttgenbach S (2012)
Vertical microbubble column – A photonic lab-on-chip for cultivation and online analysis of yeast cell cultures.
Biomicrofluidics 6:034106.
Eslahpazir Esfandabadi M, Wucherpfennig T, Krull R (2012)
Agitation induced mechanical stress in stirred tank bioreactors - Linking CFD simulations to fungal morphology.
J. Chem. Eng. Jpn. 45:742-748.
Walisko R, Krull R, Schrader J, Wittmann C (2012)
Microparticle-based morphology engineering of filamentous microorganisms for industrial bio-production.
Biotech. Lett. 34:1975-1982.
Wucherpfennig T, Schilling JV, Sieblitz D, Pump M, Schütte K, Wittmann C, Krull R (2012)
Improved assessment of aggregate size in Taxus plant cell suspension cultures using laser diffraction.
Eng. Life Sci. 12:595-602.
Geißen S U, Bennemann H, Horn H, Krull R, Neumann S (2012)
Industrieabwasserbehandlung und -recycling: Potenziale und Perspektiven.
Chem. Ing. Tech. 84:1005-1017.
Wucherpfennig T, Lakowitz A, Driouch H, Krull R, Wittmann C (2012)
Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles.
J. Vis. Exp. 61. Video.>
Poblete I, Becker J, Dohnt K, Dos Santos V M, Wittmann C (2012)
Industrial biotechnology of Pseudomonas putida and related species
Appl. Microbiol. Biotechnol. 93:2279-2290.
Becker J, Wittmann C (2012)
Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development.
Curr. Opin. Biotechnol. 23:718-726.
Korneli C, Bolten C J, Godard T, Franco-Lara E, Wittmann C (2012)
Debottlenecking recombinant protein production in Bacillus megaterium under large scale conditions - targeted precursor feeding designed from metabolomics.
Biotechnol. Bioeng. 109:1538-1550. Video.
Becker J, Wittmann C (2012)
Bio-based production of chemicals, materials and fuels – Corynebacterium glutamicum as versatile cell factory.
Curr. Opin. Biotechnol. 23:631-640.
Greis T, Helmholz K, Schöniger M H, Haarstrick A (2012)
Modelling of spatial contaminant probabilities of occurrence of chlorinated hydrocarbons in an urban aquifer.
Environ. Monit. Assess. 184:3577-3591.
Krujatz F, Haarstrick A, Nörtemann B, Greis T (2012)
Assessing the toxic effects of nickel, cadmium and EDTA on growth of the plant growth-promoting rhizobacterium Pseudomonas brassicacearum.
Water Air Soil Poll. 223:1281-1293.
Driouch H, Melzer G, Wittmann, C (2012)
Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production.
Metab. Eng. 14:47-58.
Rodrigues A L, Göcke Y, Bolten C J, Brock N L, Dickschat J S, Wittmann C (2012)
Microbial production of the drugs violacein and deoxyviolacein – analytical development and strain comparison.
Biotechnol. Lett. 34:717-720.
David F, Hebeisen M, Schade G, Franco-Lara E, Di Berardino M (2012)
Viability and membrane potential analysis of Bacillus megaterium cells by impedance flow cytometry.
Biotechnol. Bioeng. 109:483-492.
Priegnitz B E, Wargenau A, Brandt U, Rohde M, Dietrich S, Krull R, Fleißner A (2012)
The role of initial spore adhesion in pellet and biofilm formation in Aspergillus niger.
Fungal Genet. Biol. 49:30-38.
Driouch H, Hänsch R, Wucherpfennig T, Krull R, Wittmann C (2012)
Improved enzyme production by superior bio-pellets of Aspergillus niger - Targeted morphology engineering using titanate micro particles.
Biotechnol. Bioeng. 109:462-471.
Jahn D, Krull R, Wittmann C (Eds.) (2012)
From gene to product – Development of biotechnological processes by integrating genetic and engineering methods. Concluding reports, collaborative research centre SFB 578.
Cuvillier Verlag, Göttingen 2012, ISBN 978-3-642-17305-9 2.
Herbrich S, Gehder M, Krull R, Gericke KH (2011)
Label-free spatial analysis of free and enzyme-bound NAD(P)H in the presence of high concentrations of melanin.
J. Fluoresc. 22:349-355.
Becker J, Wittmann C (2011)
Tailor-made cell factories for sustainable bioproduction.
BIOspektrum 17:472-474.
Dohnt K, Sauer M, Müller M, Atallah K, Weidemann M, Gronemeyer P, Rasch D, Tielen P, Krull R (2011)
An in vitro-urinary tract catheter system to investigate biofilm development in catheter-associated urinary tract infections.
J Microbiol Meth. 87:302-308.
Wucherpfennig T, Hestler T, Krull R (2011)
Morphology engineering - Osmolality and its effect on Aspergillus niger morphology and productivity.
Microb. Cell Fact. 10:58.
David F, Steinwand M, Hust M, Bohle K, Ross A, Dübel S, Franco-Lara E (2011)
Antibody production in Bacillus megaterium: strategies and physiological implications of scaling from micro titer plates to industrial bioreactors.
Biotechnology J. 6:1516-1531.
Kind S, Kreye S, Wittmann C (2011)
Metabolic engineering of cellular transport for overproduction of the platform chemical diaminopentane in Corynebacterium glutamicum.
Metab. Eng. 13:617-627.
Kind S, Wittmann C (2011)
Bio-based production of the platform chemical 1,5-diaminopentane.
Appl. Microbiol. Biotechnol. 91:1287-1296.
Korneli C, David F, Godard T, Franco-Lara E (2011)
Influence of fructose and oxygen gradients on fed-batch recombinant protein production using Bacillus megaterium.
Eng. Life Sci. 11:338-349.
Schädel F, David F, Franco-Lara E (2011)
Evaluation of cell damage caused by cold sampling and quenching for metabolome analysis.
Appl. Microbiol. Biotechnol. 92:1261-1274.
Lueders S, David F, Steinwand M, Jordan E, Hust M, Dübel S, Franco-Lara E (2011)
Influence of the hydromechanical stress and temperature on growth and antibody fragment production with Bacillus megaterium.
Appl. Microbiol. Biotechnol. 91:81-90.
David F, Berger A, Hansch R, Rohde M, Franco-Lara E (2011)
Single cell analysis applied to antibody fragment production with Bacillus megaterium: development of advanced physiology and bioprocess state estimation tools.
Microb. Cell Fact. 10:23.
Biedendieck R, Borgmeier C, Bunk B, Stammen S, Scherling C, Meinhardt F, Wittmann C, Jahn D (2011)
Systems biology of recombinant protein production using Bacillus megaterium.
Method. Enzymol. 500:165-195.
Becker J, Zelder O, Häfner S, Schröder H, Wittmann C (2011)
From zero to hero - design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production.
Metab. Eng. 13:159-168.
Demming S, Sommer B, Llobera A, Rasch D, Krull R, Büttgenbach S (2011)
Disposable parallel PDMS microbioreactor with integrated readout grid for germination screening of Aspergillus ochraceus.
Biomicrofluidics 5:014104.
Demming S, Vila-Planas J, Zadeh S A, Edlich A, Franco-Lara E, Radespiel R, Büttgenbach S, Llobera A (2011)
Poly(dimethylsiloxane) photonic microbioreactors based on segmented waveguides for local absorbance measurement.
Electrophoresis 32:431-439.
Schmolke H, Demming S, Edlich A, Magdanz V, Büttgenbach S, Franco-Lara E, Krull R, Klages C-P (2011)
Polyelectrolyte multilayer surface functionalization of poly(dimethylsiloxane) (PDMS) for reduction of yeast cell adhesion in microfluidic devices.
Biomicrofluidics 4:44113.
Buschke N, Schröder H, Wittmann C (2011)
Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose.
Biotechnol. J. 6:306-317
Rezola A, de Figueiredo L F, Brock M, Pey J, Podhorski A, Wittmann C, Schuster S, Bockmayr A, Planes F J (2011)
Exploring metabolic pathways in genome-scale networks via generating flux modes.
Bioinformatics 27:534-540.
Driouch H, Roth A, Dersch P, Wittmann C (2010)
Filamentous fungi in good shape: Microparticles for tailor-made fungal morphology and enhanced enzyme production.
Bioengineered Bugs 2:1-5.
Salazar-Peña R, Lippe K, Alcaraz-González V, Franco-Lara E (2010)
Advanced modeling for media composition optimization applied to phototrophic growth.
IFAC P SER 11(1).
Kohlstedt M, Becker J, Wittmann C (2010)
Metabolic fluxes and beyond - systems biology understanding and engineering of microbial metabolism.
Appl. Microbiol. Biotechnol. 88:1065-1075.
David F, Westphal R, Bunk B, Jahn D, Franco-Lara E (2010)
Optimization of antibody fragment production in Bacillus megaterium: the role of metal ions on protein secretion.
J. Biotechnol. 150:115-124.
Becker J, Buschke N, Bücker R, Wittmann C (2010)
Systems level engineering of Corynebacterium glutamicum - reprogramming translational efficiency for superior production.
Eng. Life Sci. 10:430-438.
Stellmacher R, Hangebrauk J, Scholten E, von Abendroth G, Wittmann C (2010)
Fermentative Herstellung von Bernsteinsäure in Serumflaschen mit Basfia succiniciproducens DD1.
Chem. Ing. Tech. 82:1223-1229.
Kind S, Jeong W K, Schröder H, Zelder O, Wittmann C (2010)
Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum.
Appl. Environ. Microbiol. 76:5175-5180.
Stammen S, Müller B K, Korneli C, Biedendieck R, Gamer M, Franco-Lara E, Jahn D (2010)
High yield intra- and extracellular protein production using Bacillus megaterium.
Appl. Environ. Microbiol. 76:4037-4046.
Driouch H, Roth A, Dersch P, Wittmann C (2010)
Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger.
Appl. Microbiol. Biotechnol. 87:2011-2024.
Edlich A, Magdanz V, Rasch D, Demming S, Zadeh S A, Segura R, Radespiel R, Büttgenbach S, Franco-Lara E, Krull R (2010)
Microfluidic reactor for continuous cultivation of Saccharomyces cerevisiae.
Biotechnol. Prog. 26:1259-1270.
Fallet C, Rohe P, Franco-Lara E (2010)
Process optimization of the integrated production and secretion of ectoine and hydroxyectoine under hyper/hypo osmotic stress.
Biotechnol. Bioeng. 107:124-133.
Bolten C J, Schröder H, Wittmann C (2010)
Towards methionine overproduction in Corynebacterium glutamicum - methanethiol and dimethylsulfide as reduced sulfur sources.
J. Microbiol. Biotechnol. 20:1196-1203.
Kind S, Jeong W K, Schröder H, Wittmann C (2010)
Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane.
Metab. Eng. 12:341-351.
Demming S, Hahn A, Edlich A, Franco-Lara E, Krull R, Barcikowski S, Büttgenbach S (2010)
Softlithographic, partial integration of surface-active nanoparticles in a PDMS matrix for microfluidic biodevices.
Phys. Status solidi A, 207:898-903.
Eslahpazir Esfandabadi M, Hempel D C, Krull R (2010)
CFD-Anwendungen für Rührkesselreaktoren in der Bioverfahrenstechnik.
Chem. Ing. Tech. 82:229-241.
Lin P-J, Scholz A, Krull R (2010)
Effect of volumetric power input by aeration and agitation on pellet morphology and product formation of Aspergillus niger.
Biochem. Eng. J. 49:213-220.
Dickschat J S, Wickel S, Bolten C J, Nawrath T, Schulz S, Wittmann C (2010)
Pyrazine biosynthesis in Corynebacterium glutamicum.
Eur. J. Org. Chem. 2010(14):2687 - 2695.
Bahl M A, Schultheis E, Hempel D C, Nörtemann B, Franco-Lara E (2010)
Recovery and purification of the sphingan exopolysaccharide PS-EDIV.
Carbohydr. Polym. 80:1037-1041.
Doronina N V, Kaparullina E N, Trotsenko Y A, Nörtemann B, Bucheli-Witschel M, Weilenmann H-U, Egli T (2010)
Chelativorans multitrophicus gen. nov., sp. nov. and Chelativorans oligotrophicus sp. nov., aerobic, EDTA-degrading bacteria.
Int. J. Syst. Evol. Microbiol. 60:1044-1051.
Driouch H, Sommer B, Wittmann C (2010)
Morphology engineering of Aspergillus niger for improved enzyme production.
Biotechnol. Bioeng. 105:1058 - 1068.
Wittmann C, Krull R (2010)
Biosystems Engineering II - Linking Cellular Networks and Bioprocesses
Adv. Biochem. Eng. Biotechnol., Vol. 121, Scheper T (Ed.), Springer Verlag, ISBN: 978-3642138652
Fürch T, Preusse M, Tomasch J, Zech H, Wagner-Döbler I, Rabus R, Wittmann C (2009)
Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade.
BMC Microbiol. 9:209.
Schilling M, Jahn D, Hempel D C (2009)
Vom Gen zum Produkt - aber mit System.
Spektrum der Wissenschaft, Oktober 2009.
Lüders S, Fallet C, Franco-Lara E (2009)
Proteome analysis of the Escherichia coli heat shock response under steady-state conditions.
Proteome Sci. 7:36.
Schultheis E, Dreger M A, Munoz-Villegas J M, Escalante J I, Franco-Lara E, Nörtemann B (2009)
Rheological characterization of culture broth containing the exopolysaccharide PS-EDIV from Sphingomonas pituitosa DSM13101.
Biochem. Eng. J. 47:116-121.
Hille A, Neu T R, Hempel D C, Horn H (2009)
Effective diffusivities and mass fluxes in fungal biopellets.
Biotechnol. Bioeng. 103:1202-1213.
Melzer G, Eslahpazir M, Franco-Lara E, Wittmann C (2009)
Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties.
BMC Syst. Biol. 3:120. Highly accessed article.
Fallet C, Rohe P, Franco-Lara E (2009)
Process optimization of integrated ectoine production and secretion under osmotic stresss in a cascade of continuously operated bioreactors.
Chem. Eng. Trans. 17:1035-1040.
Becker J, Klopprogge C, Schröder H, Wittmann C (2009)
TCA cycle engineering for improved lysine production in Corynebacterium glutamicum.
Appl. Environ. Microbiol. 75, 7866-7869.
Fürch T, Hangebrauk J, Stellmacher R, von Abendroth G, Schröder H, Häfner S, Wittmann C (2009)
Biotech-Produktion der "Top-Value"-Chemikalie Bernsteinsäure.
Laborwelt 6:4-7.
Quek L E, Wittmann C, Nielsen L K, Krömer J O (2009)
OpenFLUX: Efficient modelling software for 13C-based metabolic flux analysis.
Microb. Cell Fact 8:25.
Böl M, Möhle R B, Haesner M, Neu T, Horn H, Krull R (2009)
3D finite element model of biofilm detachment using real biofilm structures from CLSM data.
Biotechnol. Bioeng. 103:177-186.
Schädel F, Franco-Lara E (2009)
Rapid sampling devices for metabolic engineering applications.
Appl. Microbiol. Biotechnol. 83:199-208.
Stintzing A, Pilz R, Hempel D C, Krull R (2008)
Mechanische Beanspruchungen in Mehrphasenreaktoren.
Chem. Ing. Tech. 80:1837-1842.
Krömer J.O., Bolten C., Heinzle E., Schröder H., Wittmann C. (2008)
Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR.
Microbiol., 154:3917-3930.
Lin P-J, Grimm L H, Wulkow M, Hempel D C, Krull R (2008)
Population balance modeling of the conidial aggregation of Aspergillus niger.
Biotechnol. Bioeng. 99:341-350.
Bolten C J, Wittmann C (2008)
Appropriate sampling for intracellular amino acid analysis in phylogenetically different yeasts.
Biotechnol. Lett. 30:1993-2000.
Meima J A, Mora Naranjo N, Haarstrick A (2008)
Sensitivity analysis and literature review of parameters controlling local biodegradation processes in municipal solid waste landfills.
Waste Manage 28:904-918.
Melzer G, Dalpiaz A, Grote A, Kucklick M, Göcke Y, Jonas R, Dersch P, Franco-Lara E, Nörtemann B, Hempel D C (2007)
Metabolic flux analysis using stoichiometric models for Aspergillus niger: Comparison under glucoamylase-producing and non-producing conditions.
J. Biotechnol. 132: 405-417.
Bohle K, Jungebloud A, Göcke Y, Cordes C, Horn H, Hempel D C (2007)
Selection of reference genes for normalisation of specific gene quantification data of Aspergillus niger.
J. Biotechnol. 132:353-358.
Reichel T, Haarstrick A (2007)
Modelling decomposition of MSW using genetic algorithms.
Waste Resour. Manage. 161:113-120.
Reichel T, Ivanova L K, Beaven R P, Haarstrick A (2007)
Modelling decomposition of MSW in a consolidating anaerobic reactor.
Environ. Eng. Sci. 24:1072-1083.
Möhle R B, Langemann T, Haesner M, Augustin W, Scholl S, Neu T R, Hempel D C, Horn H (2007)
Structure and shear strength of microbial biofilms as determined with Confocal Laser Scanning Microscopy and Fluid Dynamic Gauging using a novel Rotating Disc Biofilm Reactor.
Biotechnol. Bioeng. 98:747-755.
Jungebloud A, Bohle K, Göcke Y, Cordes C, Horn H, Hempel D C (2007)
Quantification of product-specific gene expression in biopellets of Aspergillus niger with real-time PCR.
Enzyme Microb. Technol. 40:653-660.
Fürch T, Hollmann R, Wittmann C, Wang W, Deckwer W-D (2007)
Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using 13C labelled substrates.
Bioproc. Biosyst. Eng. 30:47-59.
Fürch T, Wittmann C, Wang W, Franco-Lara E, Jahn D, Deckwer W-D (2007)
The effect of different carbon sources on the central metabolic fluxes and the recombinant protein production in Bacillus megaterium.
J. Biotechnol. 132:385-394.
Franco-Lara E, Krull R, Hempel D C, Haarstrick A (2007)
Specification and supervision of system performance in yeast processes.
Chem. Biochem. Eng. 4:345-355.
Bunk B, Kucklick M, Jonas R, Münch R, Schobert M, Jahn D, Hiller K (2006)
MetaQuant: a tool for the automatic quantification of GC/MS-based metabolome data.
Bioinformatics. 1;22(23):2962-5.
Emmler M, Jungebloud A, Göcke Y, Cordes C, Horn H, Hempel D C (2006)
Apparent delay of product secretion by product adsorption in Aspergillus niger.
Eng. Life Sci. 6:488-491.
Kelly S, Grimm L H, Bendig C, Hempel D C, Krull R (2006)
Effects of fluid dynamic induced shear stress on fungal growth and morphology.
Proc. Biochem. 41:2113-2117.
Kelly S, Grimm L H, Jonas R, Hempel D C, Krull R (2006)
Investigations of the morphogenesis of filamantous microorganisms.
Eng. Life Sci. 6:475-480.
Hille A, Neu T R, Hempel D C, Horn H (2006)
Einfluss der Morphologie auf Stofftransport und -umsatz in Aspergillus niger-Pellets.
Chem. Ing. Tech. 78:627-632.
Hempel D C (2006)
Development of biotechnological processes by integrating genetic and engineering methods.
Eng. Life Sci. 6:443-447.
Hempel D C (2006)
Integration gen- und verfahrenstechnischer Methoden zur Entwicklung biotechnologischer Prozesse.
Chem. Ing. Tech. 78:187-192.
Fürch T, Hollmann R, Wang W, Wittmann C, Deckwer W-D (2006)
Dynamische Untersuchungen zum Aminosäure-Stoffwechsel von Bacillus megaterium mittels stabiler Isotope.
Chem. Ing. Tech. 78:295-300.
Emmler M, Jungebloud A, Göcke Y, Cordes C, Horn H, Hempel D C (2006)
Scheinbare Sekretionsverzögerung durch Produktadsorption bei Aspergillus niger.
Chem. Ing. Tech. 78:285-288.
Deckwer W-D, Jahn D, Hempel D C, Zeng A P (2006)
Systems biology approaches to bioprocess development.
Eng. Life Sci. 6:455-469.
Krull R (2005)
Production integrated treatment of textile wastewater by closing raw material cycles.
Water Sci. Technol. 52:209-30
Schallenberg J, Enß J H, Hempel D C (2005)
The important role of local dispersed phase hold-ups for the calculation of three-phase bubble columns.
Chem. Eng. Sci. 60:6027-6033.
Rinas U, El-Enshasy H, Emmler M, Hille A, Hempel D C, Horn H (2005)
Model-based prediction of substrate conversion and protein synthesis and excretion in recombinant Aspergillus niger biopellets.
Chem. Eng. Sci. 60:2729-2739.
Pilz R, Hempel D C (2005)
Mechanical stress on suspended particles in two- and three-phase airlift loop reactors and bubble columns.
Chem. Eng. Sci. 60:6004-6012.
Hille A, Neu T R, Hempel D C, Horn H (2005)
Oxygen profiles and biomass distribution in biopellets of Aspergillus niger.
Biotechnol. Bioeng. 92:614-623.
Grimm L H, Kelly S, Völkerding I, Krull R, Hempel D C (2005)
Influence of process parameters on the aggregation of Aspergillus niger conidia.
Biotechnol. Bioeng. 92:879-88.
Grimm L H, Kelly S, Krull R, Hempel D C (2005)
Morphology and productivity of filamentous fungi.
Appl. Microbiol. Biotechnol. 69:375-38.
Emmler M, Göcke Y, Hille A, Jungebloud A, Cordes C, Horn H, Hempel D C (2004)
Modellierung der Produktbildung durch Aspergillus niger - Transport und Reaktionsvorgänge in Biopellets.
Chem. Ing. Tech. 76:1259-1260.
Grimm L H, Kelly S, Hengstler J, Göbel A, Krull R, Hempel D C (2004)
Kinetic studies on the aggregation of Aspergillus niger conidia.
Biotechnol. Bioeng. 87:213-218.
Grimm L H, Emmler M, Krull R, Hempel D C, Horn H (2004)
Morphologie und Produktbildung des Pellet-bildenden Pilzes Aspergillus niger.
Chem. Ing. Tech. 75:1232.
Haarstrick A, Hempel D C, Münnich K, Fricke K, Ziehmann G (2004)
Deponiemonitoring - Abfallstatus, Simulation des Emissionsverhaltens - Teil III.
Müll und Abfall 7:2-8.
Haarstrick A, Mora-Naranjo N, Meima J, Hempel D C (2004)
Modelling anaerobic degradation in municipal landfills.
Environ. Eng. Sci. 21:201-214.
Haarstrick A, Hempel D C (2004)
Modellierung des Langzeitemissionsverhaltens von Deponien.
Mitteilungen des IGB-TU BS 74.
Kelly S, Grimm L, Hengstler J, Schultheis E, Krull R, Hempel D C (2004)
Agitation effects on submerged growth and product formation of Aspergillus niger.
Bioprocess Biosyst. Eng. 26:315-323
Horn H, Staudt C, Neu T R, León Ohl A, Bößmann M, Hempel D C (2004)
Untersuchungsmethoden für Biofilmsysteme.
Chem. Ing. Tech.
Kelly S, Grimm L H, Hengstler J, Krull R, Hempel D C (2004)
Modellierung der Pelletentwicklung von Aspergillus niger.
Chem. Ing. Tech. 75:1249
Krull R, Döpkens E (2004)
Recycling of dyehouse effluents by biological and chemical treatment.
Water Sci. Technol. 49:311-317
Mora-Naranjo N, Meima J A, Haarstrick A, Hempel D C (2004)
Modelling and experimental investigation of environmental influences on the acetate and methane formation in solid waste.
Waste Manage. 24:763-773
Pilz R D, Mahnke EU, Hempel D C (2004)
Mechanical stresses in bubble columns and airlift loop-reactors operated in two and three phase mode.
J. Chem. Eng. Japan 37:955-961
Bößmann M, Staudt C, Neu T R, Horn H, Hempel D C (2003)
Investigation and modeling of growth, structure and oxygen penetration in particle supported biofilms.
Chem. Eng. Technol. 26:219-222
Döpkens E, Krull R, Metzen P (2003)
Reinigung und Recycling von Abwässern der Textilveredelung.
Wasserwirtschaft Wassertechnik WWT 13:20-23
Haarstrick A, Mora Naranjo N, Meima J A, Hempel D C (2003)
Monitoring und Prognose des Langzeitemissionsverhaltens von Siedlungsabfällen.
GWF Wasser-Abwasser 144:862-870
Horn H, Hille A, Kelly S, Grimm L, Hengstler J, Emmler M, Jungebloud A, Cordes C, Krull R, Hempel D C, Jahn D, El-Enshasy H, Rinas U (2003)
Einfluss der Pelletmorphologie von Aspergillus niger auf Stoffumsatz und Produktbildung – experimentelle Untersuchungen und Modellierung.
Chem. Ing. Tech. 75:1070-1071
Mora-Naranjo N, Alamar-Provecho C, Meima J, Haarstrick A, Hempel D C (2003)
Experimental investigation and modelling of the effect of sulfate on anaerobic biodegradation process in municipal solid waste.
Water Sci. Technol.48:221-227
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