TU BRAUNSCHWEIG

Dr. Kerstin Schmidt-Hohagen

Dr. Kerstin Schmidt-Hohagen
Senior Scientist
Room 141 (BRICS)
Tel.:+49 (0) 531-391-55204
Fax:+49 (0) 531-391-55198
E-Mail:k.schmidt-hohagen[at]tu-braunschweig.de

Group:
Microbialmetabolism

Since 10/2007          
Senior Scientist at the Department of Bioinformatics & Biochemistry

03/2007 – 09/2007                            
Postdoc, Institute for Microbiology, Prof. Dr. Dieter Jahn 

10/2003 – 02/2007                
Graduate student, Institute for Microbiology, Prof. Dr. Dieter Jahn
PhD thesis: “Molecular strategies of Pseudomonas aeruginosa for survival under oxygen-limiting conditions”

10/1998 – 09/2003                
Studies in Biology, Technische Universität Braunschweig, Germany.
Degree: Diplom
Title: “Der fermentative Stoffwechsel von Pseudomonas aeruginosa”

Publications

  • Bill N, Tomasch J, Riemer A, Müller K, Kleist S, Schmidt-Hohagen K, Wagner-Döbler I, Schomburg D (2017) Fixation of CO2 using the ethylmalonyl-CoA pathway in the photoheterotrophic marine bacterium Dinoroseobacter shibae. Environ Microbiol doi:10.1111/1462-2920.13746.
  • Wolf J, Stark H, Fafenrot K, Albersmeier A, Pham TK, Müller KB, Meyer BH, Hoffmann L, Shen L, Albaum SP, Kouril T, Schmidt-Hohagen K, Neumann-Schaal M, Bräsen C, Kalinowski J, Wright PC, Albers SV, Schomburg D, Siebers B (2016) A systems biology approach reveals major metabolic changes in the thermoacidophilic archaeon Sulfolobus solfataricus in response to the carbon source L-fucose versus D-glucose. Mol Microbiol 102:882-908.
  • Trautwein K, Will SE, Hulsch R, Maschmann U, Wiegmann K, Hensler M, Michael V, Rupperberg H, Wünsch D, Feenders C, Neumann-Schaal M, Kaltenhäuser S, Ulbrich M, Schmidt-Hohagen K, Blasius B, Pertersen J, Schomburg D, Rabus R (2016) Native plasmids restrict growth of Phaeobacter inhibens DSM 17395: Energetic costs of plasmids assessed by quantitative physiological analyses. Environ Microbiol 18:4817-4829.
  • Kleist S, Ulbrich M, Bill N, Schmidt-Hohagen K, Geffers R, Schomburg D (2016) Dealing with salinity extremes and nitrogen limitation – an unexpected strategy of the marine bacterium Dinoroseobacter shibae. Environ Microbiol, doi: 10.1111/1462-2920. 13266.
  • Vorwerk H, Huber C, Mohr J, Bunk B, Bhuju S, Wensel O, Spröer C, Fruth A, Flieger A, Schmidt-Hohagen K, Schomburg D, Eisenreich W, Hofreuter D (2015) A transferable plasticity region in Campylobacter coli allows isolates of an otherwise non-glycolytic food-borne pathogen to catabolize glucose. Mol Microbiol 98(5):809-30. doi: 10.1111/mmi.13159.
  • Zischka M, Künne CT, Blom J, Wobser D, Sakιnç T, Schmidt-Hohagen K, Dabrowski PW, Nitsche A, Hübner J, Hain T, Chakraborty T, Linke B, Goesmann A, Voget S, Daniel R, Schomburg D, Hauck R, Hafez HM, Tielen P, Jahn D, Solheim M, Sadowy E, Larsen J, Jensen LB, Ruiz-Garbajosa P, Quiñones Pérez D, Mikalsen T, Bender J, Steglich M, Nübel U, Witte W, Werner G (2015) Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40. BMC Genomics 16:175. doi: 10.1186/s12864-015-1367-x.
  • Hartmann T, Baronian G, Nippe N, Voss M, Schulthess B, Wolz C, Eisenbeis J, Schmidt-Hohagen K, Gaupp R, Sunderkötter C, Beisswenger C, Bals R, Somerville GA, Herrmann M, Molle V, Bischoff M (2014) The catabolite control protein E (CcpE) affects virulence determinant production and pathogenesis of Staphylococcus aureus. J Biol Chem 289(43):29701-11. doi: 10.1074/jbc.M114.584979
  • Vorwerk H, Mohr J, Huber C, Wensel O, Schmidt-Hohagen K, Gripp E, Josenhans C, Schomburg D, Eisenreich W, Hofreuter D (2014) Utilization of host-derived cysteine-containing peptides overcomes the restricted sulphur metabolism of Campylobacter jejuni. Mol Microbiol 93(6):1224-45. doi: 10.1111/mmi.12732.
  • Laass S, Kleist S, Bill N, Drüppel K, Kossmehl S, Wöhlbrand L, Rabus R, Klein J, Rohde M, Bartsch A, Wittmann C, Schmidt-Hohagen K, Tielen P, Jahn D, Schomburg D (2014) Gene regulatory and metabolic adaptation processes of Dinoroseobacter shibae DFL12T during oxygen depletion. J Biol Chem 289:13219-31.
  • Reimer LC, Spura J, Schmidt-Hohagen K, Schomburg D (2014) High-throughput screening of a Corynebacterium glutamicum mutant library on genomic and metabolic level. PloS One 9(2):e86799. doi: 10.1371/journal.pone.0086799
  • Drüppel K, Hensler M, Trautwein K, Koßmehl S, Wöhlbrand L, Schmidt-Hohagen K, Ulbrich M, Bergen N, Meier-Kolthoff JP, Göker M, Klenk HP, Schomburg D, Rabus R (2014) Pathways and substrate-specific regulation of amino acid degradation in Phaeobacter inhibens DSM 17395 (archetype of the marine Roseobacter clade). Environ Microbiol 16:218-38.
  • Rex R, Bill N, Schmidt-Hohagen K, Schomburg D (2013) Swimming in light. A large-scale computational analysis of the metabolism of Dinoroseobacter shibae. PloS Comput Biol 9(10):e1003224
  • Zech H, Hensler M, Koßmehl S, Drüppel K, Wöhlbrand L, Trautwein K, Colby T, Schmidt J, Reinhardt R, Schmidt-Hohagen K, Schomburg D, Rabus R (2013) Dynamics of amino acid utilization in Phaeobacter gallaeciensis DSM 17395. Proteomics 13(18-19):2869-85.
  • Zech H, Hensler M, Koßmehl S, Drüppel K, Wöhlbrand L, Trautwein K, Hulsch R, Maschmann U, Colby T, Schmidt J, Reinhardt R, Schmidt-Hohagen K, Schomburg D, Rabus R (2013) Adaptation of Phaeobacter gallaeciensis DSM 17395 to growth with complex nutrients. Proteomics 13(18-19):2851-68.
  • Hofreuter D, Mohr J, Wensel O, Rademacher S, Schreiber K, Schomburg D, Gao B, Galán JE (2012) Contribution of amino acid catabolism to the tissue specific persistence of Campylobacter jejuni in a murine colonization model. PLoS One. 2012;7(11):e50699.
  • Abu Dawud R, Schreiber K, Schomburg D & Adjaye J (2012) Human embryonic stem cells and embryonal carcinoma cells have overlapping and distinct metabolic signatures. PlosOne 7(6):e39896.
  • Gripp E, Hlahla D, Didelot X, Kops F, Maurischat S, Tedin K, Alter T, Ellerbroek L, Schreiber K, Schomburg D, Janssen T, Bartholomäus P, Hofreuter D, Woltemate S, Uhr M, Brenneke B, Grüning P, Gerlach G, Wieler L, Suerbaum S, Josenhans C (2011) Closely related Campylobacter jejuni strains from different sources reveal a generalist rather than a specialist lifestyle. BMC Genomics 12:584. doi: 10.1186/1471-2164-12-584.
  • Zaparty M, Esser D, Gertig S, Haferkamp P, Kouril T, Manica A, Pham TK, Reimann J, Schreiber K, Sierocinski P, Teichmann D, van Wolferen M, von Jan M, Wieloch P, Albers SV, Driessen AJ, Klenk HP, Schleper C, Schomburg D, van der Oost J, Wright PC, Siebers B. (2010) "Hot standards" for the thermoacidophilic archaeon Sulfolobus solfataricus. Extremophiles 14(1):119-42. doi: 10.1007/s00792-009-0280-0.
  • Hiller K, Hangebrauk J, Jäger C, Spura J, Schreiber K & Schomburg D (2009) MetaboliteDetector: comprehensive tool for targeted and non-targeted GC/MS based metabolome analysis. Anal Chem 81:3429-39.
  • Spura J, Reimer LC, Wieloch P, Schreiber K, Buchinger S & Schomburg D (2009) A method for enzyme quenching in microbial metabolome analysis successfully applied to gram-positive and gram-negative bacteria and yeast. Anal Biochem 394:192-201.
  • Zech H, Thole S, Schreiber K, Kalhöfer D, Voget S, Schomburg D, Rabus R (2009) Growth phase-dependent global protein and metabolite profiles of Phaeobacter gallaeciensis strain DSM 17395, a member of the marine Roseobacter-clade. Proteomics 9(14):3677-3697.
  • Boes N, Schreiber K, Schobert M (2008) SpoT-triggered stringent response controls usp gene expression in Pseudomonas aeruginosa. J Bacteriol 190: 189-199.
  • Benkert B, Quäck N, Schreiber K, Jaensch L, Jahn D, Schobert M (2008) Nitrate-responsive NarX-NarL represses arginine-mediated induction of the Pseudomonas aeruginosa arginine fermentation arcDABC operon. Microbiology 154: 3053-3060.
  • Choi C, Muench R, Leupold S, Klein J, Siegel I, Thielen B, Benkert B, Kucklick M, Schobert M, Barthelmes J, Ebeling C, Haddad I, Scheer M, Grote A, Hiller K, Bunk B, Schreiber K, Retter I, Schomburg D, Jahn D (2007) SYSTOMONAS - an integrated database for systems biology analysis of Pseudomonas. Nucleic Acids Res, 35 (Database issue): D533-7.
  • Schreiber K, Krieger R, Benkert B, Eschbach M, Arai H, Schobert M, Jahn D (2007) The anaerobic regulatory network required for Pseudomonas aeruginosa nitrate respiration. J Bacteriol 189: 4310-4314.
  • Berger B, Pridmore RD, Barretto C, Delmas-Julien F, Schreiber K, Arigoni F, Brüssow H (2007) Similarity and differences in the Lactobacillus acidophilus group identified by polyphasic analysis and comparative genomics. J Bacteriol 189: 1311-1321.
  • Boes N, Schreiber K, Härtig E, Jaensch L, Schobert M. 2006. The Pseudomonas aeruginosa universal stress protein PA4352 is essential for surviving anaerobic energy stress. J Bacteriol 188: 6529-6538.
  • Schreiber K, Boes N, Eschbach M, Jaensch L, Wehland J, Bjarnsholt T, Givskov M, Hentzer M, Schobert M (2006) Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein. J Bacteriol 188: 659-668.
  • Eschbach M, Schreiber K, Trunk K, Buer J, Jahn D, Schobert M (2004) Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation. J Bacteriol 186: 4596-4604.


  last changed 12.12.2017
TU_Icon_E_Mail_1_17x17_RGB pagetop