TU BRAUNSCHWEIG

Prof. Dr. Karsten Hiller

Prof. Dr. Karsten Hiller
Professor
Room 145 (BRICS)
Tel.:   +49 (0) 531-391-55201
E-Mail:karsten.hiller[at]tu-braunschweig.de

since 07/2016
University of Braunschweig, Germany,
Full Professor for Biochemistry and Bioinformatics

01/2016 - 07/2016
Luxembourg Centre for Systems Biomedicine (LCSB),Luxembourg,
Associate Professor for Cellular Metabolism

2010 - 2016
Luxembourg Centre for Systems Biomedicine (LCSB), Luxembourg,
Head of the Metabolomics Group

2008 - 2010
Massachusetts Institute of Technology (MIT), USA
Department of Chemical Engineering
Postdoc

2007 - 2008
University of Braunschweig, Germany,
Department of Bioinformatics and Biochemistry
Postdoc

2006
University of Braunschweig, Germany,
Institute for Microbiology
Dr. rer. nat. in Bioinformatics/Microbiology

1997 - 2003
University of Braunschweig, Germany,
Study of Biology and Computer Science,
Diploma in Biology

Publications
Google Scholar


2017

  • 1. Hootman, K. C., Trezzi, J.-P., Kraemer, L., Burwell, L. S., Dong, X., Guertin, K. A.,
    Jaeger, C., Stover, P. J., Hiller, K. & Cassano, P. A. Erythritol is a pentose-phosphate
    pathway metabolite and associated with adiposity gain in young adults. Proceedings of
    the National Academy of Sciences, 201620079 (2017)
  • 2. Mak, T. W., Grusdat, M., Duncan, G. S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld,
    C., Hao, Z., Brüstle, A., Itsumi, M., Jäger, C., Chen, Y., Pinkenburg, O., Camara, B.,
    Ollert, M., Bindslev-Jensen, C., Vasiliou, V., Gorrini, C., Lang, P. A., Lohoff, M., Harris,
    I. S., Hiller, K. & Brenner, D. Glutathione Primes T Cell Metabolism for Inflammation.
    English. Immunity 46, 675–689 (2017)
  • 3. Meiser, J., Vazquez, A. & Hiller, K. DJ1 at the interface between neuro-degeneration
    and cancer. Oncotarget (2017)
  • 4. Trezzi, J.-P., Jäger, C., Galozzi, S., Barkovits, K., Marcus, K., Mollenhauer, B. & Hiller,
    K. Metabolic profiling of body fluids and multivariate data analysis. MethodsX 4, 95–103
    (2017)

2016

  • 5. Battello, N., Zimmer, A. D., Goebel, C., Dong, X., Behrmann, I., Haan, C., Hiller, K. &
    Wegner, A. The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of
    hepatic cells. Cancer & Metabolism 4, 1 (2016)
  • 6. Cordes, T., Wallace, M., Michelucci, A., Divakaruni, A. S., Sapcariu, S. C., Sousa, C.,
    Koseki, H., Cabrales, P., Murphy, A. N., Hiller, K. & Metallo, C. M. Immunoresponsive
    Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate
    Levels. en. J. Biol. Chem. 291, 14274–14284 (2016)
  • 7. Delcambre, S., Nonnenmacher, Y. & Hiller, K. en. Mitochondrial Mechanisms of Degen-
    eration and Repair in Parkinson’s Disease 25–47 (Springer, Cham, 2016). cited: DOI:
    10.1007/978-3-319-42139-1_2
  • 8. Doppler, M., Kluger, B., Bueschl, C., Schneider, C., Krska, R., Delcambre, S., Hiller,
    K., Lemmens, M. & Schuhmacher, R. Stable Isotope-Assisted Evaluation of Different
    Extraction Solvents for Untargeted Metabolomics of Plants. en. International Journal of
    Molecular Sciences 17, 1017 (2016)
  • 9. Lorendeau, D., Rinaldi, G., Boon, R., Spincemaille, P., Metzger, K., Jäger, C., Christen,
    S., Dong, X., Kuenen, S., Voordeckers, K.,Hiller K., Sarah-Maria Fendt et al. Dual loss of succinate dehydrogenase
    (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH
    mutant tumors. Metabolic Engineering (2016)
  • 10. Meiser, J., Delcambre, S., Wegner, A., Jäger, C., Ghelfi, J., d’Herouel, A. F., Dong,
    X., Weindl, D., Stautner, C., Nonnenmacher, Y., Michelucci, A., Popp, O., Giesert, F.,
    Schildknecht, S., Krämer, L., Schneider, J. G., Woitalla, D., Wurst, W., Skupin, A.,
    Weisenhorn, D. M. V., Krüger, R., Leist, M. & Hiller, K. Loss of DJ-1 impairs antioxidant
    response by altered glutamine and serine metabolism. Neurobiology of Disease 89, 112–125
    (2016)
  • 11. Meiser, J., Krämer, L., Sapcariu, S. C., Battello, N., Ghelfi, J., D’Herouel, A. F., Skupin,
    A. & Hiller, K. Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through
    Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression.
    en. J. Biol. Chem. 291, 3932–3946 (2016)
  • 12. Nonnenmacher, Y., Palorini, R., d’Herouël, A. F., Krämer, L., Neumann-Schaal, M.,
    Chiaradonna, F., Skupin, A., Wegner, A. & Hiller, K. Analysis of mitochondrial metabolism
    in situ: Combining stable isotope labeling with selective permeabilization. Metabolic Engi-
    neering (2016).
  • 13. Palorini, R., Votta, G., Pirola, Y., Vitto, H. D., Palma, S. D., Airoldi, C., Vasso, M.,
    Ricciardiello, F., Lombardi, P. P., Cirulli, C., Rizzi, R., Nicotra, F., Hiller, K., Gelfi, C.,
    Alberghina, L. & Chiaradonna, F. Protein Kinase A Activation Promotes Cancer Cell
    Resistance to Glucose Starvation and Anoikis. PLOS Genet 12, e1005931 (2016)
  • 14. Sapcariu, S. C., Kanashova, T., Dilger, M., Diabaté, S., Oeder, S., Passig, J., Radischat, C.,
    Buters, J., Sippula, O., Streibel, T., Paur, H.-R., Schlager, C., Mülhopt, S., Stengel, B.,
    Rabe, R., Harndorf, H., Krebs, T., Karg, E., Gröger, T., Weiss, C., Dittmar, G., Hiller,
    K. & Zimmermann, R. Metabolic Profiling as Well as Stable Isotope Assisted Metabolic
    and Proteomic Analysis of RAW 264.7 Macrophages Exposed to Ship Engine Aerosol
    Emissions: Different Effects of Heavy Fuel Oil and Refined Diesel Fuel. PLOS ONE 11,
    e0157964 (2016)
  • 15. Trezzi, J.-P., Bulla, A., Bellora, C., Rose, M., Lescuyer, P., Kiehntopf, M., Hiller, K. &
    Fay, B. LacaScore: a novel plasma sample quality control tool based on ascorbic acid and
    lactic acid levels. Metabolomics 12 (2016)
  • 16. Ullmann, P., Qureshi-Baig, K., Rodriguez, F., Ginolhac, A., Nonnenmacher, Y., Ternes, D.,
    Weiler, J., Gäbler, K., Bahlawane, C., Hiller, K., et al. Hypoxia-responsive miR-210
    promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by
    inducing lactate production. Oncotarget 7, 65454–65470 (2016)
  • 17. Weindl, D., Cordes, T., Battello, N., Sapcariu, S. C., Dong, X., Wegner, A. & Hiller, K.
    Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis.
    Cancer & Metabolism 4, 10 (2016).
  • 18. Weindl, D., Wegner, A. & Hiller, K. MIA: non-targeted mass isotopolome analysis. en.
    Bioinformatics 32, 2875–2876 (2016)
  • 19. Zhang, H., Badur, M. G., Divakaruni, A. S., Parker, S. J., Jäger, C., Hiller, K., Mur-
    phy, A. N. & Metallo, C. M. Distinct Metabolic States Can Support Self-Renewal and
    Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions. Cell
    Reports 16, 1536–1547 (2016)

2015

  • 20. Buescher, J. M., Antoniewicz, M. R., Boros, L. G., Burgess, S. C., Brunengraber, H., Clish,
    C. B., DeBerardinis, R. J., Feron, O., Frezza, C., Ghesquiere, B., Gottlieb, E., Hiller, K.,
    Jones, R. G., Kamphorst, J. J., Kibbey, R. G., Kimmelman, A. C., Locasale, J. W., Lunt,
    S. Y., Maddocks, O. D., Malloy, C., Metallo, C. M., Meuillet, E. J., Munger, J., Nöh, K.,
    Rabinowitz, J. D., Ralser, M., Sauer, U., Stephanopoulos, G., St-Pierre, J., Tennant,
    D. A., Wittmann, C., Vander Heiden, M. G., Vazquez, A., Vousden, K., Young, J. D.,
    Zamboni, N. & Fendt, S.-M. A roadmap for interpreting 13C metabolite labeling patterns
    from cells. Current Opinion in Biotechnology. Systems biology • Nanobiotechnology 34,
    189–201 (2015)
  • 21. Cordes, T., Michelucci, A. & Hiller, K. Itaconic Acid: The Surprising Role of an Industrial
    Compound as a Mammalian Antimicrobial Metabolite. Annual Review of Nutrition 35,
    451–473 (2015)

  • 22. Hootman, K., Trezzi, J., Bailey, J., Burwell, L., Guertin, K., Hiller, K., Cassano, P., et al.
    Metabolomic Markers Associated with Central Adiposity Gain in Young Adults. The
    FASEB Journal 29, 736–19 (2015)
  • 23. Oeder, S., Kanashova, T., Sippula, O., Sapcariu, S. C., Streibel, T., Arteaga-Salas, J. M.,
    Passig, J., Dilger, M., Paur, H.-R., Schlager, C., Mülhopt, S., Diabaté, S., Weiss, C.,
    Stengel, B., Rabe, R., Harndorf, H., Torvela, T., Jokiniemi, J. K., Hirvonen, M.-R.,
    Schmidt-Weber, C., Traidl-Hoffmann, C., BéruBé, K. A., Wlodarczyk, A. J., Prytherch,
    Z., Michalke, B., Krebs, T., Prévôt, A. S. H., Kelbg, M., Tiggesbäumker, J., Karg, E.,
    Jakobi, G., Scholtes, S., Schnelle-Kreis, J., Lintelmann, J., Matuschek, G., Sklorz, M.,
    Klingbeil, S., Orasche, J., Richthammer, P., Müller, L., Elsasser, M., Reda, A., Gröger,
    T., Weggler, B., Schwemer, T., Czech, H., Rüger, C. P., Abbaszade, G., Radischat, C.,
    Hiller, K., Buters, J. T. M., Dittmar, G. & Zimmermann, R. Particulate Matter from
    Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects
    on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions. PLOS
    ONE 10, e0126536 (2015)
  • 24. Schildknecht, S., Pape, R., Meiser, J., Karreman, C., Strittmatter, T., Odermatt, M.,
    Cirri, E., Friemel, A., Ringwald, M., Pasquarelli, N., Ferger, B., Brunner, T., Marx,
    A., Möller, H. M., Hiller, K. & Leist, M. Preferential Extracellular Generation of the
    Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate
    MPDP+. Antioxidants & Redox Signaling 23, 1001–1016 (2015)
  • 25. Trezzi, J.-P., Vlassis, N. & Hiller, K. Advances in Cancer Biomarkers: From biochemistry
    to clinic for a critical revision (Springer Netherlands, 2015)
  • 26. Wegner, A., Meiser, J., Weindl, D. & Hiller, K. How metabolites modulate metabolic
    flux. Current Opinion in Biotechnology 34, 16–22 (2015)
  • 27. Weindl, D., Wegner, A. & Hiller, K. Metabolome-wide analysis of stable isotope labeling-
    Is it worth the effort? Frontiers in Physiology 6, 344 (2015)
  • 28. Weindl, D., Wegner, A. & Hiller, K. Methods in Enzymology 277–302 (Academic Press,
    2015)
  • 29. Weindl, D., Wegner, A., Jäger, C. & Hiller, K. Isotopologue ratio normalization for
    non-targeted metabolomics. Journal of Chromatography A 1389, 112–119 (2015)

2014

  • 30. Ammerlaan, W., Trezzi, J.-P., Lescuyer, P., Mathay, C., Hiller, K. & Betsou, F. Method
    Validation for Preparing Serum and Plasma Samples from Human Blood for Downstream
    Proteomic, Metabolomic, and Circulating Nucleic Acid-Based Applications. Biopreserva-
    tion and biobanking 12, 269–280 (2014)
  • 31. Ammerlaan, W., Trezzi, J.-P., Mathay, C., Hiller, K. & Betsou, F. Method Validation
    for Preparing Urine Samples for Downstream Proteomic and Metabolomic Applications.
    Biopreservation and biobanking 12, 351–357 (2014)
  • 32. Krug, A. K., Gutbier, S., Zhao, L., Pöltl, D., Kullmann, C., Ivanova, V., Förster, S., Jagtap,
    S., Meiser, J., Leparc, G., Schildknecht, S., Adam, M., Hiller, K., Farhan, H., Brunner,
    T., Hartung, T., Sachinidis, A. & Leist, M. Transcriptional and metabolic adaptation of
    human neurons to the mitochondrial toxicant MPP+. en. Cell Death Dis 5, e1222 (2014)
  • 33. Missios, P., Zhou, Y., Guachalla, L. M., von Figura, G., Wegner, A., Chakkarappan, S. R.,
    Binz, T., Gompf, A., Hartleben, G., Burkhalter, M. D., Wulff, V., Günes, C., Sattler,
    R. W., Song, Z., Illig, T., Klaus, S., Böhm, B. O., Wenz, T., Hiller, K. & Rudolph, K. L.
    Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere
    dysfunctional mice. en. Nat Commun 5, 4924 (2014)
  • 34. Sapcariu, S. C., Kanashova, T., Weindl, D., Ghelfi, J., Dittmar, G. & Hiller, K. Simulta-
    neous extraction of proteins and metabolites from cells in culture. MethodsX 1, 74–80
    (2014)
  • 35. Wegner, A., Weindl, D., Jäger, C., Sapcariu, S. C., Dong, X., Stephanopoulos, G. &
    Hiller, K. Fragment Formula Calculator (FFC): Determination of chemical formulas for
    fragment ions in mass spectrometric data. Analytical chemistry 86, 2221–2228 (2014)

2013

  • 36. Hiller, K. & Metallo, C. M. Profiling metabolic networks to study cancer metabolism.
    Current opinion in biotechnology 24, 60–68 (2013)
  • 37. HILLER, K., MICHELUCCI, A., CORDES, T., WEGNER, A., GHELFI, J. & BALLING,
    R. METHOD TO PREDICT THE PRESENCE OF INFLAMMATION OR ITACONIC
    ACID, IRG1 AND/OR PROTEIN IRG1 IN A SUBJECT AND PHARMACEUTI-
    CAL COMPOSITION FOR TREATING OR PREVENTING INFLAMMATION (2013).
    cited: WO Patent 2,013,041,692
  • 38. Hiller, K., Wegner, A., Weindl, D., Cordes, T., Metallo, C. M., Kelleher, J. K. &
    Stephanopoulos, G. NTFD—a stand-alone application for the non-targeted detection of
    stable isotope-labeled compounds in GC/MS data. Bioinformatics 29, 1226–1228 (2013)
  • 39. McGuirk, S., Gravel, S.-P., Deblois, G., Papadopoli, D. J., Faubert, B., Wegner, A., Hiller,
    K., Avizonis, D., Akavia, U. D., Jones, R. G., Giguère, V. & St-Pierre, J. PGC-1 supports
    glutamine metabolism in breast cancer. Cancer & Metabolism 1, 22 (2013)
  • 40. Meiser, J., Weindl, D. & Hiller, K. Complexity of dopamine metabolism. Cell Communi-
    cation and Signaling 11 (2013)
  • 41. Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T.,
    Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C. L., Medina, E., Balling, R. &
    Hiller, K. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing
    itaconic acid production. en. PNAS 110, 7820–7825 (2013)
  • 42. Müller, S. & Hiller, K. From multi-omics to basic structures of biological systems. Current
    opinion in biotechnology 24, 1–3 (2013)
  • 43. Wegner, A., Sapcariu, S. C., Weindl, D. & Hiller, K. Isotope Cluster-Based Compound
    Matching in Gas Chromatography/Mass Spectrometry for Non-Targeted Metabolomics.
    Analytical chemistry 85, 4030–4037 (2013)
  • 44. WILMES, P., ROUME, H., HILLER, K., CORDES, T., et al. METHOD AND KIT
    FOR THE ISOLATION OF GENOMIC DNA, RNA, PROTEINS AND METABOLITES
    FROM A SINGLE BIOLOGICAL SAMPLE (2013). cited: WO Patent 2,013,029,919

2012

  • 45. Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell,
    C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. Reductive glutamine metabolism
    by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380–384 (2012)
  • 46. Roume, H., Muller, E. E., Cordes, T., Renaut, J., Hiller, K. & Wilmes, P. A biomolecular
    isolation framework for eco-systems biology. The ISME journal 7, 110–121 (2012)

2011

  • 47. Gaglio, D., Metallo, C. M., Gameiro, P. A., Hiller, K., Danna, L. S., Balestrieri, C.,
    Alberghina, L., Stephanopoulos, G. & Chiaradonna, F. Oncogenic K-Ras decouples glucose
    and glutamine metabolism to support cancer cell growth. Molecular systems biology 7
    (2011)
  • 48. Hiller, K., Metallo, C. & Stephanopoulos, G. Elucidation of cellular metabolism via
    metabolomics and stable-isotope assisted metabolomics. Current pharmaceutical biotech-
    nology 12, 1075–1086 (2011)
  • 49. Wegner, A., Cordes, T., Michelucci, A. & Hiller, K. The Application of Stable Isotope
    Assisted Metabolomics in Biomedicine. Current Biotechnology 1, 88–97 (2011)

2010

  • 50. Hiller, K., Metallo, C. M., Kelleher, J. K. & Stephanopoulos, G. Nontargeted elucidation
    of metabolic pathways using stable-isotope tracers and mass spectrometry. Analytical
    chemistry 82, 6621–6628 (2010)

2009

  • 51. Haddad, I., Hiller, K., Frimmersdorf, E., Benkert, B., Schomburg, D. & Jahn, D. An
    emergent self-organizing map based analysis pipeline for comparative metabolome studies.
    In silico biology 9, 163–178 (2009)
  • 52. Hiller, K., Hangebrauk, J., Jäger, C., Spura, J., Schreiber, K. & Schomburg, D. Metabo-
    liteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based
    metabolome analysis. Anal. Chem 81, 3429–3439 (2009)

2007

  • 53. Choi, C., Münch, R., Leupold, S., Klein, J., Siegel, I., Thielen, B., Benkert, B., Kucklick,
    M., Schobert, M., Barthelmes, J.,Ebeling C.,Haddad I.,Scheer M., Grote A.,Hiller K.,
    Bunk B.,Schreiber K.,Retter I.,Schomburg D.,Jahn D.,et al. SYSTOMONAS—an integrated database for
    systems biology analysis of Pseudomonas. Nucleic acids research 35, D533–D537 (2007)

2006

  • 54. Bunk, B., Kucklick, M., Jonas, R., Münch, R., Schobert, M., Jahn, D. & Hiller, K.
    MetaQuant: a tool for the automatic quantification of GC/MS-based metabolome data.
    Bioinformatics 22, 2962–2965 (2006)
  • 55. Hiller, K., Grote, A., Maneck, M., Münch, R. & Jahn, D. JVirGel 2.0: computational pre-
    diction of proteomes separated via two-dimensional gel electrophoresis under consideration
    of membrane and secreted proteins. Bioinformatics 22, 2441–2443 (2006)
  • 56. Scheer, M., Klawonn, F., Münch, R., Grote, A., Hiller, K., Choi, C., Koch, I., Schobert,
    M., Härtig, E., Klages, U., et al. JProGO: a novel tool for the functional interpretation of
    prokaryotic microarray data using Gene Ontology information. Nucleic acids research 34,
    W510–W515 (2006)

2005

  • 57. Grote, A., Hiller, K., Scheer, M., Münch, R., Nörtemann, B., Hempel, D. C. & Jahn, D.
    JCat: a novel tool to adapt codon usage of a target gene to its potential expression host.
    Nucleic acids research 33, W526–W531 (2005)
  • 58. Münch, R., Hiller, K., Grote, A., Scheer, M., Klein, J., Schobert, M. & Jahn, D. Virtual
    Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes.
    Bioinformatics 21, 4187–4189 (2005)

2004

  • 59. Hiller, K., Grote, A., Scheer, M., Münch, R. & Jahn, D. PrediSi: prediction of signal
    peptides and their cleavage positions. Nucleic acids research 32, W375–W379 (2004)

2003

  • 60. Hiller, K., Schobert, M., Hundertmark, C., Jahn, D. & Münch, R. JVirGel: calculation
    of virtual two-dimensional protein gels. Nucleic acids research 31, 3862–3865 (2003)
  • 61. Münch, R., Hiller, K., Barg, H., Heldt, D., Linz, S., Wingender, E. & Jahn, D. PRODORIC:
    prokaryotic database of gene regulation. Nucleic acids research 31, 266–269 (2003)

  aktualisiert am 17.11.2017
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